Abstract:
BACKGROUND:Given the evidence that reasoning biases contribute to delusional persistence and change, several research groups have made systematic efforts to modify them. The current experiment tested the hypothesis that targeting reasoning biases would result in change in delusions. METHODS:One hundred and one participants with current delusions and schizophrenia spectrum psychosis were randomly allocated to a brief computerized reasoning training intervention or to a control condition involving computer-based activities of similar duration. The primary hypotheses tested were that the reasoning training intervention, would improve (1) data gathering and belief flexibility and (2) delusional thinking, specifically paranoia. We then tested whether the changes in paranoia were mediated by changes in data gathering and flexibility, and whether working memory and negative symptoms moderated any intervention effects. RESULTS:On an intention-to-treat analysis, there were significant improvements in state paranoia and reasoning in the experimental compared with the control condition. There was evidence that changes in reasoning mediated changes in paranoia, although this effect fell just outside the conventional level of significance after adjustment for baseline confounders. Working memory and negative symptoms significantly moderated the effects of the intervention on reasoning. CONCLUSION:The study demonstrated the effectiveness of a brief reasoning intervention in improving both reasoning processes and paranoia. It thereby provides proof-of-concept evidence that reasoning is a promising intermediary target in interventions to ameliorate delusions, and thus supports the value of developing this approach as a longer therapeutic intervention.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Garety P,Waller H,Emsley R,Jolley S,Kuipers E,Bebbington P,Dunn G,Fowler D,Hardy A,Freeman Ddoi
10.1093/schbul/sbu103subject
Has Abstractpub_date
2015-03-01 00:00:00pages
400-10issue
2eissn
0586-7614issn
1745-1701pii
sbu103journal_volume
41pub_type
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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