Abstract:
BACKGROUND:The clinical high-risk state for psychosis (HRP) is associated with an enhanced probability of developing a psychotic episode over a relatively short period of time. However, the extent to which different diagnostic types of illness develop remains unclear. METHODS:A systematic review was performed to identify studies of HRP participants reporting International Classfication of Diseases/Diagnostic and Statistical Manual of Mental Disorders diagnostic outcomes at follow-up. Demographic, clinical, and methodological variables were extracted from each publication or obtained directly from its authors. A meta-analysis was performed of transition to schizophrenic (SP) or affective psychoses (AP) and to specific diagnostic categories. Statistical heterogeneity and small study bias were assessed, and meta-regressions were performed. RESULTS:Twenty-three studies were retrieved, including a total of 2182 HRP participants, 560 (26%) of them developed a frank psychotic disorder over the follow-up time (mean = 2.35 y). Among HRP participants who developed psychosis, 73% were diagnosed with SP and only 11% with AP (Risk Ratio, RR = 5.43, 95% CI from 3.35 to 8.83). The specific transition risk to ICD/DSM schizophrenia was of 15.7% (over 2.35y). Heterogeneity was statistically significant and moderate in magnitude. Use of basic symptoms criteria in the baseline clinical assessment was associated with a further increase in the proportion progressing to SP vs AP (RR = 17.1). There was no evidence of publication bias and the sensitivity analysis confirmed robustness of the above results. CONCLUSIONS:The HRP state is heterogeneous in term of longitudinal diagnoses; however, the current HRP diagnostic criteria appear strongly biased toward an identification of early phases of SP rather than AP.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Fusar-Poli P,Bechdolf A,Taylor MJ,Bonoldi I,Carpenter WT,Yung AR,McGuire Pdoi
10.1093/schbul/sbs060subject
Has Abstractpub_date
2013-07-01 00:00:00pages
923-32issue
4eissn
0586-7614issn
1745-1701pii
sbs060journal_volume
39pub_type
杂志文章,meta分析,评审abstract::The evidence suggesting that genetic factors are involved in the etiology of schizophrenia is reviewed. Despite methodological and other difficulties, independent lines of research--family, twin, and adoption studies--point in a common direction: Persons genetically at risk for schizophrenia are more likely to become ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/6.3.404
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm159
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbj004
更新日期:2006-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006903
更新日期:2001-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-03-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/15.4.585
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Cannabis use has been identified as a potent predictor of the earlier onset of psychosis, but meta-analysis has not indicated that it has a clear effect in established psychosis. AIM:To assess the association between cannabis and outcomes, including whether change in cannabis use affects symptoms and functi...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,随机对照试验
doi:10.1093/schbul/sbr152
更新日期:2013-03-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/16.1.31
更新日期:1990-01-01 00:00:00
abstract::Given the rising costs of health care and the decrease in public expenditures on mental health care, policy-makers and program managers must identify cost-effective approaches for treating severely mentally ill patients. During the last year, there have been two major cost-effectiveness studies implemented in Californ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/17.3.461
更新日期:1991-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbs049
更新日期:2012-06-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/21.2.227
更新日期:1995-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbt087
更新日期:2014-05-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,随机对照试验
doi:10.1093/schbul/sbx168
更新日期:2018-10-17 00:00:00
abstract::Gender effects have been reported quite consistently in schizophrenia, with male patients having an earlier age of onset, poorer functional outcome, greater negative symptoms and cognitive impairment, and less severe positive symptoms. Because age of onset, cognitive impairments, and negative symptoms are all correlat...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006850
更新日期:2001-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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journal_title:Schizophrenia bulletin
pub_type:
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更新日期:2018-10-15 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/5.1.4
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/13.1.77
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abstract::Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究
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更新日期:2015-11-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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更新日期:2020-10-12 00:00:00
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pub_type: 杂志文章
doi:10.1093/schbul/13.4.727
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-05-01 00:00:00