Contingency valuation and preferences of health states associated with side effects of antipsychotic medications in schizophrenia.

Abstract:

:The purpose of this study was to investigate the construct validity and the test-retest reliability of the willingness to pay (WTP) method for estimating health state preferences associated with side effects of antipsychotic medication. Ninety-six schizophrenia patients on antipsychotics were asked (1) how much they would be willing to pay to get rid of side effects with 100 percent probability, (2) a standard gamble (SG) question measuring utilities of patient's health state associated with side effects, and (3) their WTP to get rid of side effects based on the utility found with SG. Patients were divided into three groups based on severity of side effects. There was a significant difference between side effect severity groups for (1) the utility associated with side effects (Kruskal-Wallis [K-W] chi-square = 8.48, p = 0.014), and (2) their WTP to get rid of side effects with either 100 percent probability (K-W chi-square = 14.32,p = 0.001) or based on the utility associated with side effects (K-W chi-square = 5.96, p = 0.051). There was a significant correlation between utility and the WTP based on utility (Spearman r = -0.42, p = 0.003). Because of a wide variation in side effects at the 1-month interval, we were unable to assess the test-retest reliability of SG and WTP. Our results suggest that WTP has some construct validity in valuating and measuring preferences of health states associated with side effects of antipsychotics in schizophrenia.

journal_name

Schizophr Bull

journal_title

Schizophrenia bulletin

authors

Sevy S,Nathanson K,Schechter C,Fulop G

doi

10.1093/oxfordjournals.schbul.a006903

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

643-51

issue

4

eissn

0586-7614

issn

1745-1701

journal_volume

27

pub_type

杂志文章
  • People with schizophrenia in five countries: conceptual similarities and intercultural differences in family caregiving.

    abstract::The European Psychiatric Services: Inputs Linked to Outcomes and Needs (EPSILON) study was a EU BIOMED-2-funded comparative, cross-national, cross-sectional study aimed (1) to produce standardized versions of five key research instruments in five languages, and (2) to compare the characteristics, needs, and life quali...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究

    doi:10.1093/oxfordjournals.schbul.a007029

    authors: van Wijngaarden B,Schene A,Koeter M,Becker T,Knapp M,Knudsen HC,Tansella M,Thornicroft G,Vázquez-Barquero JL,Lasalvia A,Leese M,EPSILON Study Group.

    更新日期:2003-01-01 00:00:00

  • Healthy Adolescent Performance With Standardized Scoring Tables for the MATRICS Consensus Cognitive Battery: A Multisite Study.

    abstract:OBJECTIVE:The aim of this study was to develop standardized scores and scoring tables for test performance in healthy adolescents for the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) for each year from 11 to 19 years of age, by sex, with T scores ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究

    doi:10.1093/schbul/sby131

    authors: Smelror RE,Jørgensen KN,Lonning V,Kelleher I,Cannon M,DeRosse P,Malhotra AK,Karlsgodt KH,Andreassen OA,Lundberg M,Edbom T,Cleland N,Ueland T,Myhre AM,Rund BR,Agartz I

    更新日期:2019-06-18 00:00:00

  • Time use of unemployed and employed single male schizophrenia subjects.

    abstract::The poverty and lack of social role in the lives of many people with schizophrenia seem similar to those of people in long-term unemployment, raising the possibility that there may be some commonalities in their time use and community functioning. To test this possibility, the social anxiety, time use, and activity pa...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/22.4.659

    authors: Hayes RL,Halford WK

    更新日期:1996-01-01 00:00:00

  • Psychotogenic drug use and neuroleptic response.

    abstract::When fixed doses of haloperidol or perphenazine were used in two separate studies, we found that psychotic males with a prior history of psychotogenic drug use had a poorer early neuroleptic response even in the early stages of their psychotic disorder than psychotic males who had not previously used significant amoun...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/16.1.81

    authors: Bowers MB Jr,Mazure CM,Nelson JC,Jatlow PI

    更新日期:1990-01-01 00:00:00

  • Cross-modal reaction time and schizophrenic attentional deficit: a critical review.

    abstract::This article focuses on the cross-modal reaction time paradigm, which has been used to study deviation patterns of shifting attention across stimulus modalities in schizophrenic patients. Cross-modal reaction time research involving pathological and nonpathological populations is reviewed. The influence of sex, stimul...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/6.4.654

    authors: Mannuzza S

    更新日期:1980-01-01 00:00:00

  • Violent crime arrests and paranoid schizophrenia: the White House case studies.

    abstract::We have previously reported on typically paranoid schizophrenic patients who attempted to see the President or other prominent American political figures based on hallucinations or delusional beliefs. By obtaining arrest records on these White House Cases (WHCs), we were able to determine which individuals had murder ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/14.2.279

    authors: Shore D,Filson CR,Johnson WE

    更新日期:1988-01-01 00:00:00

  • Modeling schizophrenia using induced pluripotent stem cell-derived and fibroblast-induced neurons.

    abstract::Although schizophrenia affects a number of brain regions and produces a range of clinical symptoms, we believe its origins lie at the level of single neurons and simple networks. Owing to this, as well as to its high degree of heritability, we hypothesize that schizophrenia is amenable to cell-based studies in vitro. ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbs127

    authors: Tran NN,Ladran IG,Brennand KJ

    更新日期:2013-01-01 00:00:00

  • Management of the adverse effects of clozapine.

    abstract::Clozapine has been found to be superior to traditional neuroleptics in the treatment of refractory schizophrenia and is increasingly being used to treat schizophrenia, affective disorders, some neurological disorders, and aggression. For many patients, clozapine offers new hope for the successful pharmacological manag...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.schbul.a033333

    authors: Young CR,Bowers MB Jr,Mazure CM

    更新日期:1998-01-01 00:00:00

  • Toward a model of impaired reality testing in rats.

    abstract::Schizophrenia is a chronic brain disorder that affects about 1.1% of the adult US population annually. Hallucinations, delusions, and impaired reality testing are prominent symptoms of the disorder. Modeling these symptoms is difficult because it is unclear how to assess impaired reality testing in animals. Animals ca...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbp050

    authors: McDannald M,Schoenbaum G

    更新日期:2009-07-01 00:00:00

  • Cortical Contributions to Distinct Symptom Dimensions of Catatonia.

    abstract::Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sby192

    authors: Hirjak D,Kubera KM,Northoff G,Fritze S,Bertolino AL,Topor CE,Schmitgen MM,Wolf RC

    更新日期:2019-10-24 00:00:00

  • Methodological issues in tardive dyskinesia research.

    abstract::Research into tardive dyskinesia, an involuntary movement disorder secondary to chronic neuroleptic treatment, has so far produced conflicting results with no clear clinical applications. Heterogeneous diagnostic criteria, research designs, and rating scales, plus an emphasis on single-drug trials, are probably respon...

    journal_title:Schizophrenia bulletin

    pub_type: 临床试验,杂志文章

    doi:10.1093/schbul/5.1.1

    authors: Nasrallah HA

    更新日期:1979-01-01 00:00:00

  • Maternal prepregnant body mass and risk of schizophrenia in adult offspring.

    abstract::This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring between 1959 and 1967 to ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a033452

    authors: Schaefer CA,Brown AS,Wyatt RJ,Kline J,Begg MD,Bresnahan MA,Susser ES

    更新日期:2000-01-01 00:00:00

  • A social network approach and the revolving door patient.

    abstract::Traditional psychiatric treatment approaches have not been very successful with the "revolving door patient." A variety of findings suggest that the social network, as opposed to the individual patient, may be a more viable locus for intervention. A conceptual review and analysis of the literature reveals two construc...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/12.2.262

    authors: Morin RC,Seidman E

    更新日期:1986-01-01 00:00:00

  • A randomized trial of the efficacy and safety of the H3 antagonist ABT-288 in cognitive impairment associated with schizophrenia.

    abstract:INTRODUCTION:ABT-288 is a highly potent histamine-3 receptor antagonist that has demonstrated pro-cognitive effects in preclinical models relevant to schizophrenia. This study evaluated the efficacy and safety of two doses of ABT-288 in the treatment of cognitive impairment associated with schizophrenia. METHODS:A ran...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/schbul/sbt240

    authors: Haig GM,Bain E,Robieson W,Othman AA,Baker J,Lenz RA

    更新日期:2014-11-01 00:00:00

  • Smoking in schizophrenia: diagnostic specificity, symptom correlates, and illness severity.

    abstract:BACKGROUND:Cigarette smoking was consistently found to be more prevalent in individuals with schizophrenia than in other psychiatric groups and the general population. These findings have been interpreted as evidence of a specific association between schizophrenia and smoking. However, the supporting data come primaril...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbn066

    authors: Kotov R,Guey LT,Bromet EJ,Schwartz JE

    更新日期:2010-01-01 00:00:00

  • A meta-analysis of mentalizing impairments in adults with schizophrenia and autism spectrum disorder.

    abstract::Mentalizing has been examined both in autism spectrum disorder (ASD) and schizophrenia (SCZ) primarily by either cognitive-linguistic (referred to as verbal) or emotion recognition from eyes (referred to as visual) mentalizing tasks. Each type of task is thought to measure different aspects of mentalizing. Differences...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,meta分析

    doi:10.1093/schbul/sbt048

    authors: Chung YS,Barch D,Strube M

    更新日期:2014-05-01 00:00:00

  • Concurrent and predictive validity of components of disordered thinking in schizophrenia.

    abstract::Although the various manifestations of disordered thought have played a central role in diagnostic and theoretical considerations of schizophrenia, such symptoms have not been found specific to schizophrenia, and at best have shown weak relations to outcome. As part of a 7-year followup study of a sample of young, acu...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/12.3.427

    authors: Knight RA,Elliott DS,Roff JD,Watson CG

    更新日期:1986-01-01 00:00:00

  • The search for elusive structure: a promiscuous realist case for researching specific psychotic experiences such as hallucinations.

    abstract::Problems in psychiatric classification have impeded research into psychopathology for more than a century. Here, I briefly review several new approaches to solving this problem, including the internalizing-externalizing-psychosis spectra, the 5-factor model of psychotic symptoms, and the more recent network approach. ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbu044

    authors: Bentall RP

    更新日期:2014-07-01 00:00:00

  • Neuropsychological and psychophysiological correlates of psychosocial functioning in schizophrenia.

    abstract::This study tested hypothesized relationships between neuropsychological and psychophysiological variables and concurrent levels of clinical and psychosocial functioning in schizophrenia. The sample consisted of 40 subjects diagnosed with a chronic schizophrenia spectrum disorder and living in community-based settings....

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/23.1.19

    authors: Brekke JS,Raine A,Ansel M,Lencz T,Bird L

    更新日期:1997-01-01 00:00:00

  • Application of electroencephalography to the study of cognitive and brain functions in schizophrenia.

    abstract::The electroencephalogram (EEG) recorded from the human scalp is widely used to study cognitive and brain functions in schizophrenia. Current research efforts are primarily devoted to the assessment of event-related potentials (ERPs) and event-related oscillations (EROs), extracted from the ongoing EEG, in patients wit...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbm016

    authors: van der Stelt O,Belger A

    更新日期:2007-07-01 00:00:00

  • Role of selenium and other trace elements in the geography of schizophrenia.

    abstract::Medical geology is the application of trace element geography to epidemiology. This approach is used to compare the geographic distribution of selenium and other trace elements in soil and food with that of high schizophrenia rates in the United States and other countries. Since the comparison is most statistically si...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/20.2.387

    authors: Brown JS Jr

    更新日期:1994-01-01 00:00:00

  • Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation.

    abstract::Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects par...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbu115

    authors: Allen P,Chaddock CA,Egerton A,Howes OD,Barker G,Bonoldi I,Fusar-Poli P,Murray R,McGuire P

    更新日期:2015-03-01 00:00:00

  • The relevance of empirical research in bioethics.

    abstract::Empirical research related to ethical issues in clinical research has grown dramatically in recent years. However, little attention has been devoted to the ethical relevance of the findings from this research. In order to examine the value and limitations of ethics-related empirical research, we discuss 3 case studies...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbj004

    authors: Miller FG,Wendler D

    更新日期:2006-01-01 00:00:00

  • Detecting improvement in quality of life and symptomatology in schizophrenia.

    abstract::Instrument-based scores are often used as outcome measures. However, little is known about what changes in scores mean in terms of a clinical assessment of improvement or deterioration. The purpose of this report was to determine how much change in standard instrument scores represents a clinically detectable improvem...

    journal_title:Schizophrenia bulletin

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.schbul.a006869

    authors: Cramer J,Rosenheck R,Xu W,Henderson W,Thomas J,Charney D,Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.

    更新日期:2001-01-01 00:00:00

  • Schizophrenia with onset in adolescence: an 11-year followup.

    abstract::This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/19.4.831

    authors: Krausz M,Müller-Thomsen T

    更新日期:1993-01-01 00:00:00

  • The Relationship Between Clinical and Personal Recovery in Patients With Schizophrenia Spectrum Disorders: A Systematic Review and Meta-analysis.

    abstract::Patients describe experiencing personal recovery despite ongoing symptoms of psychosis. The aim of the current research was to perform a meta-analysis investigating the relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders. A comprehensive OvidSP database search was perf...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/schbul/sbx088

    authors: Van Eck RM,Burger TJ,Vellinga A,Schirmbeck F,de Haan L

    更新日期:2018-04-06 00:00:00

  • Methodological comments: McFarlane et al.

    abstract::Does the McFarlane et al study provide a model for practical trials? Unfortunately, not. The methodological problems are here reviewed and used as a springboard to set out methodological criteria that might define such a model. ...

    journal_title:Schizophrenia bulletin

    pub_type: 评论,杂志文章

    doi:10.1093/schbul/sbu139

    authors: Kraemer HC

    更新日期:2015-01-01 00:00:00

  • What predicts a good response to cognitive remediation interventions?

    abstract::Cognitive remediation is a behavioral intervention designed to improve cognition in people who have suffered a decline in neuropsychological functioning. The application of cognitive remediation for people with schizophrenia has become increasingly popular. In this article we attempt to determine what factors moderate...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbi045

    authors: Medalia A,Richardson R

    更新日期:2005-10-01 00:00:00

  • At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk.

    abstract:BACKGROUND:The clinical high-risk state for psychosis (HRP) is associated with an enhanced probability of developing a psychotic episode over a relatively short period of time. However, the extent to which different diagnostic types of illness develop remains unclear. METHODS:A systematic review was performed to ident...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/schbul/sbs060

    authors: Fusar-Poli P,Bechdolf A,Taylor MJ,Bonoldi I,Carpenter WT,Yung AR,McGuire P

    更新日期:2013-07-01 00:00:00

  • Measuring changes in functional status among patients with schizophrenia: the link with cognitive impairment.

    abstract::Cognitive impairment associated with schizophrenia (CIAS) includes neuropsychological deficits in attention, working memory, verbal learning, and problem solving. These deficits have been shown to be linked to impairment in functional status (eg, social behavior, work performance, and activities of daily living) among...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbl004

    authors: Matza LS,Buchanan R,Purdon S,Brewster-Jordan J,Zhao Y,Revicki DA

    更新日期:2006-10-01 00:00:00