Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date.

abstract：:The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms ...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Douglas MS,Bellack AS,Morrison RL

更新日期：1991-01-01 00:00:00

abstract：:Cognitive deficits are a central feature of schizophrenia and occur in first-degree relatives of schizophrenic probands, even in the absence of psychotic symptoms. A number of cognitive domains have been implicated including measures of response inhibition and working memory. While the stability of cognitive deficits ...

journal_title：Schizophrenia bulletin

authors： Ross RG,Wagner B,Heinlein S,Zerbe GO

更新日期：2008-01-01 00:00:00

abstract：:The literature on schizophrenia has reported a trend toward higher concordance rates for females in both monozygotic and dizygotic same-sexed twins. The validity of this finding is open to question. Rosenthal (1961 and 1962) pointed out that females are more likely than males to become inhabitants of chronic wards. Mo...

journal_title：Schizophrenia bulletin

authors： Samuels L

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. METHODS:I...

journal_title：Schizophrenia bulletin

authors： Lavigne KM,Rapin LA,Metzak PD,Whitman JC,Jung K,Dohen M,Lœvenbruck H,Woodward TS

更新日期：2015-01-01 00:00:00

abstract：:Cognitive remediation improves cognition in patients with schizophrenia, but its effect on other relevant factors such as negative symptoms and functional outcome has not been extensively studied. In this hospital-based study, 84 inpatients with chronic schizophrenia were recruited from Alava Hospital (Spain). All of ...

journal_title：Schizophrenia bulletin

authors： Sánchez P,Peña J,Bengoetxea E,Ojeda N,Elizagárate E,Ezcurra J,Gutiérrez M

更新日期：2014-05-01 00:00:00

abstract：:Psychotic-like experiences (PLEs) increase the risk of schizophrenia and other psychotic disorders yet are common in the community. Some PLEs, such as those associated with depression, distress, and poor functioning, may confer increased risk. The aim of this study is to determine the prevalence of PLEs in a nonpsycho...

journal_title：Schizophrenia bulletin

authors： Yung AR,Buckby JA,Cotton SM,Cosgrave EM,Killackey EJ,Stanford C,Godfrey K,McGorry PD

更新日期：2006-04-01 00:00:00

abstract：:The study describes the Cardiff Anomalous Perceptions Scale (CAPS), a new validated measure of perceptual anomalies. The 32-item CAPS measure is a reliable, self-report scale, which uses neutral language, demonstrates high content validity, and includes subscales that measure distress, intrusiveness, and frequency of ...

journal_title：Schizophrenia bulletin

authors： Bell V,Halligan PW,Ellis HD

更新日期：2006-04-01 00:00:00

abstract：:Neurological soft signs (NSS) are well documented in individuals with schizophrenia (SZ), yet so far, the relationship between NSS and specific symptom expression is unclear. We studied 76 SZ patients using magnetic resonance imaging (MRI) to determine associations between NSS, positive symptoms, gray matter volume (G...

journal_title：Schizophrenia bulletin

authors： Wolf RC,Rashidi M,Schmitgen MM,Fritze S,Sambataro F,Kubera KM,Hirjak D

更新日期：2020-10-24 00:00:00

abstract：:Over the past 20 years, there has been a relatively quiet but persistent effort to investigate anatomical neuropathology in schizophrenia. This effort has involved post-mortem histopathology using novel preparation procedures, pneumoencephalography, and computed tomography. The bulk of this research is critically revi...

journal_title：Schizophrenia bulletin

authors： Weinberger DR,Wagner RL,Wyatt RJ

更新日期：1983-01-01 00:00:00

abstract：:A substantial proportion of patients with schizophrenia experience the onset of their illness by age 18. Data from phenomenological, cognitive, neuroimaging, and genetic studies suggest a similar profile of clinical and neurobiological abnormalities between early- and adult-onset patients. However, children and adoles...

journal_title：Schizophrenia bulletin

authors： Kumra S,Charles Schulz S

更新日期：2008-01-01 00:00:00

abstract：:Remitting illness such as affective or schizoaffective disorder is appropriately described by a vulnerability model. Clinical evidence is reviewed here to clarify the relationship between the affective-disorder-like and schizophrenia-like symptoms in a schizoaffective episode. A model is proposed which treats vulnerab...

journal_title：Schizophrenia bulletin

authors： Braden W

更新日期：1984-01-01 00:00:00

abstract：:Social cognitive deficits are associated with psychotic symptoms, but the nature of this association remains unknown. This study uses a genetically sensitive cross-trait cross-sibling design to investigate the nature of the overlap between both phenotypes. A sample of 1032 patients, 1017 of their healthy siblings, and...

journal_title：Schizophrenia bulletin

authors： Fett AK,Maat A,GROUP Investigators.

更新日期：2013-01-01 00:00:00

abstract：:In contrast with issues of consent capacity, financial capacity has received surprisingly little clinical or ethical attention in the psychiatric literature. Issues of financial capacity emerge frequently regarding clients with serious mental illness (SMI), and their resolution has practical and ethical significance f...

journal_title：Schizophrenia bulletin

authors： Marson DC,Savage R,Phillips J

更新日期：2006-01-01 00:00:00

abstract：:Cognitive deficits are a central and debilitating aspect of schizophrenia and other major mental illnesses. Although they are largely refractory to pharmacotherapy, multiple studies have now shown that large and lasting improvements in cognition can result from behavioral interventions. We will review our work over th...

journal_title：Schizophrenia bulletin

authors： Wexler BE,Bell MD

更新日期：2005-10-01 00:00:00

abstract：:Psychobiological research in child psychiatry requires rigorous assessment of behavior and multiple perspectives on brain function through neurochemical, neuroendocrine, psychophysiological, and other advanced methods. The serious neuropsychiatric disorders of childhood, such as autism, attention deficit disorder, and...

journal_title：Schizophrenia bulletin

authors： Young JG,Cohen DJ,Shaywitz SE,Caparulo BK,Kavanagh ME,Hunt RD,Leckman JF,Anderson GM,Detlor J,Harcherik D,Shaywitz BA

更新日期：1982-01-01 00:00:00

abstract：:In a sample of 75 women recruited from the community, we measured trauma/maltreatment history and symptoms of schizotypal personality disorder, using both questionnaire and interview measures. As hypothesized, individuals with histories of trauma/maltreatment had elevated levels of schizotypal symptoms. Among types of...

journal_title：Schizophrenia bulletin

authors： Berenbaum H,Valera EM,Kerns JG

更新日期：2003-01-01 00:00:00

abstract：:Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, ...

journal_title：Schizophrenia bulletin

authors： Sun L,Yang X,Jiang J,Hu X,Qing Y,Wang D,Yang T,Yang C,Zhang J,Yang P,Wang P,Cai C,Wang J,He L,Wan C

更新日期：2018-06-06 00:00:00

abstract：:The purpose of this study was to investigate the construct validity and the test-retest reliability of the willingness to pay (WTP) method for estimating health state preferences associated with side effects of antipsychotic medication. Ninety-six schizophrenia patients on antipsychotics were asked (1) how much they w...

journal_title：Schizophrenia bulletin

authors： Sevy S,Nathanson K,Schechter C,Fulop G

更新日期：2001-01-01 00:00:00

abstract：:Pharmacologic agents currently used or being studied for the treatment of schizophrenia are reviewed. Neuroleptic medications are still the mainstay of treatment, but recent studies suggest new approaches to dosage and to the treatment of acute psychosis. Lithium is beneficial in psychotic illnesses with acute onset a...

journal_title：Schizophrenia bulletin

authors： Donaldson SR,Gelenberg AJ,Baldessarini RJ

更新日期：1983-01-01 00:00:00

abstract：:The design of the Positive and Negative Syndrome Scale (PANSS) with item levels ranging from 1 to 7 leads to the trivial result that the 30-item scale's zero level (no symptoms) is 30. This causes serious problems when ratios are calculated which always implicitly depend on a natural zero point (equals 0). Recent publ...

journal_title：Schizophrenia bulletin

authors： Obermeier M,Mayr A,Schennach-Wolff R,Seemüller F,Möller HJ,Riedel M

更新日期：2010-05-01 00:00:00

abstract：:A number of psychosocial treatments are available for persons with schizophrenia that include social skills training, cognitive behavioral therapy, cognitive remediation, and social cognition training. These treatments are reviewed and discussed in terms of how they address key components of functional recovery such a...

journal_title：Schizophrenia bulletin

authors： Kern RS,Glynn SM,Horan WP,Marder SR

更新日期：2009-03-01 00:00:00

abstract：:Recent advances in functional genomics have facilitated the identification of multiple genes and isoforms associated with the genetic risk of schizophrenia, yet the causal variations remain largely unclear. A previous study reported that the schizophrenia risk single-nucleotide polymorphism (SNP) rs7085104 at 10q24.32...

journal_title：Schizophrenia bulletin

authors： Cai X,Yang ZH,Li HJ,Xiao X,Li M,Chang H

更新日期：2021-01-23 00:00:00

abstract：:There is an increasing emphasis on identifying individuals with schizophrenia earlier and earlier in their disease process, with the assumption that earlier identification translates into earlier treatment, which translates into improved outcome. Unfortunately, one age cohort, children under 13 years of age, have been...

journal_title：Schizophrenia bulletin

authors： Ross RG,Schaeffer J,Compagnon N,Heinlein S,Beresford C,Farley G

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Schizophrenia leads to significant personal costs matched by high economic costs. Cognitive function is a strong predictor of disabilities in schizophrenia, which underpin these costs. This study of cognitive remediation therapy (CRT), which has been shown to improve cognition and reduce disability ...

journal_title：Schizophrenia bulletin

authors： Reeder C,Harris V,Pickles A,Patel A,Cella M,Wykes T

更新日期：2014-11-01 00:00:00

abstract：:Between 5% and 10% of people with psychosis will die by suicide, a rate which is 20-75 times higher than the general population. This risk is even greater in those not taking antipsychotic medication. We examined whether negative appraisals of psychotic experiences and negative metacognitive beliefs about losing menta...

journal_title：Schizophrenia bulletin

authors： Hutton P,Di Rienzo F,Turkington D,Spencer H,Taylor P

更新日期：2019-01-01 00:00:00

abstract：:The nature and definition of schizotypy, as the latent liability for schizophrenia capable of generating various phenotypic and endophenotypic outcomes, is reviewed. The proceedings of the 2017 meeting of the International Consortium on Schizotypy Research are included in this Special Section and they are presented as...

journal_title：Schizophrenia bulletin

authors： Lenzenweger MF

更新日期：2018-10-15 00:00:00

abstract：:In addition to introducing the six articles joined by our thematic outlook, this article addresses the importance of subcortical structures as they may be related to information processing and the life experience of schizophrenic patients. This is a heuristic exercise aimed at bridging the conceptual gaps between clin...

journal_title：Schizophrenia bulletin

authors： Patterson T

更新日期：1987-01-01 00:00:00

abstract：:Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained attention in schizophrenia patients, although its neural mechanisms are unknown. Understanding the neural basis of this effect may lead to new treatment strategies for this cognitiv...

journal_title：Schizophrenia bulletin

authors： Hong LE,Schroeder M,Ross TJ,Buchholz B,Salmeron BJ,Wonodi I,Thaker GK,Stein EA

更新日期：2011-03-01 00:00:00

abstract：:The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior ci...

journal_title：Schizophrenia bulletin

authors： Egerton A,Murphy A,Donocik J,Anton A,Barker GJ,Collier T,Deakin B,Drake R,Eliasson E,Emsley R,Gregory CJ,Griffiths K,Kapur S,Kassoumeri L,Knight L,Lambe EJB,Lawrie SM,Lees J,Lewis S,Lythgoe DJ,Matthews J,McGuire

更新日期：2020-09-10 00:00:00

abstract：:Increased critical stimulus duration among nonpsychotic subjects with Minnesota Multiphasic Personality Inventory 2-7-8 profiles in the Merritt and Balogh letter-discrimination procedure is consistent with the view that this abnormality might be a vulnerability indicator for a poor prognosis, chronic type of schizophr...

journal_title：Schizophrenia bulletin

authors： Nuechterlein KH,Dawson ME

更新日期：1985-01-01 00:00:00