First person account: schizoaffective disorder and suicide.

abstract：:Genetic variants conferring risk for schizophrenia (SCZ) have been extensively studied, but the role of posttranscriptional mechanisms in SCZ is not well studied. Here we performed the first genome-wide microRNA (miRNA) expression profiling in serum-derived exosome from 49 first-episode, drug-free SCZ patients and 46 ...

journal_title：Schizophrenia bulletin

authors： Du Y,Yu Y,Hu Y,Li XW,Wei ZX,Pan RY,Li XS,Zheng GE,Qin XY,Liu QS,Cheng Y

更新日期：2019-10-24 00:00:00

abstract：:Educating the public that mental illness is a brain disease is a popular strategy for combating mental illness stigma. Evidence suggests that while such an approach reduces blame for mental illness, it may unintentionally exacerbate other components of stigma, particularly the benevolence and dangerousness stigmas. Co...

journal_title：Schizophrenia bulletin

authors： Corrigan PW,Watson AC

更新日期：2004-01-01 00:00:00

abstract：:In 1917, Eugen Bleuler published an article (Mendelismus bei Psychosen, speziell bei der Schizophrenie [Mendelism in the Psychoses, especially Schizophrenia]) in response to the recently published first systematic family study of dementia praecox (DP) by Ernst Rüdin, then working under Kraepelin in Munich. Although br...

journal_title：Schizophrenia bulletin

authors： Kendler KS

更新日期：2020-07-08 00:00:00

abstract：:Negative symptoms of schizophrenia remain an area of substantial unmet clinical need. By convening a consensus conference in January 2005, the NIMH has taken a leading role in stimulating a resurgence of interest in methodological considerations related to development of new medications for treating negative symptoms....

journal_title：Schizophrenia bulletin

authors： Alphs L

更新日期：2006-04-01 00:00:00

abstract：:The electroencephalogram (EEG) recorded from the human scalp is widely used to study cognitive and brain functions in schizophrenia. Current research efforts are primarily devoted to the assessment of event-related potentials (ERPs) and event-related oscillations (EROs), extracted from the ongoing EEG, in patients wit...

journal_title：Schizophrenia bulletin

authors： van der Stelt O,Belger A

更新日期：2007-07-01 00:00:00

abstract：:There is some evidence that schizotypal traits are related to a genetic or familial liability to develop schizophrenia. However, it is unclear whether the number of schizotypal traits is elevated in parents of schizophrenia patients compared with controls. This study used the Schizotypal Personality Questionnaire to i...

journal_title：Schizophrenia bulletin

authors： Appels MC,Sitskoorn MM,Vollema MG,Kahn RS

更新日期：2004-01-01 00:00:00

abstract：:Research on the effectiveness of short-term education programs in changing societal attitudes about mental illness has been mixed. Education efforts seem to be mediated by characteristics of the program participants. This study determines whether the effects of a specially prepared, semester-long course on severe ment...

journal_title：Schizophrenia bulletin

authors： Holmes EP,Corrigan PW,Williams P,Canar J,Kubiak MA

更新日期：1999-01-01 00:00:00

abstract：:Cognitive deficits are a central and debilitating aspect of schizophrenia and other major mental illnesses. Although they are largely refractory to pharmacotherapy, multiple studies have now shown that large and lasting improvements in cognition can result from behavioral interventions. We will review our work over th...

journal_title：Schizophrenia bulletin

authors： Wexler BE,Bell MD

更新日期：2005-10-01 00:00:00

abstract：:Family studies of schizophrenia frequently include relatives of schizophrenia probands with diagnoses falling within the schizophrenia spectrum. As part of an ongoing genetic linkage study of schizophrenia, the authors examined case material from 50 relatives (of schizophrenia probands) who received a DSM-III-R diagno...

journal_title：Schizophrenia bulletin

authors： Gladis MM,Levinson DF,Mowry BJ

更新日期：1994-01-01 00:00:00

abstract：:The New York High-Risk Project began in 1971 as a prospective, longitudinal study of (1) children of one or two schizophrenic parents and (2) comparison groups of children whose parents had other or no psychiatric disorders. The former were examined because they were known to be at high risk--some 10-25 percent for ch...

journal_title：Schizophrenia bulletin

authors： Erlenmeyer-Kimling L,Cornblatt B

更新日期：1987-01-01 00:00:00

abstract：:Childhood trauma (CT) has been identified as a potential risk factor for the onset of psychotic disorders. However, to date, there is limited consensus with respect to which symptoms may ensue after exposure to trauma in early life, and whether specific pathways may account for these associations. The aim of the prese...

journal_title：Schizophrenia bulletin

authors： Isvoranu AM,van Borkulo CD,Boyette LL,Wigman JT,Vinkers CH,Borsboom D,Group Investigators.

更新日期：2017-01-01 00:00:00

abstract：:Hallucinations in children and adolescents are now known to occur on a continuum from healthy to psychopathology-related phenomena. Although hallucinations in young populations are mostly transient, they can cause substantial distress. Despite hallucinations being widely investigated, research so far has had limited i...

journal_title：Schizophrenia bulletin

authors： Maijer K,Hayward M,Fernyhough C,Calkins ME,Debbané M,Jardri R,Kelleher I,Raballo A,Rammou A,Scott JG,Shinn AK,Steenhuis LA,Wolf DH,Bartels-Velthuis AA

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Executive control of attention in schizophrenia has recently been assessed by means of the Attention Network Test (ANT). In the past, for tasks assessing executive attention, findings in schizophrenia have been contradictory, among others suggesting a lack of increased stimulus interference effects. Attentio...

journal_title：Schizophrenia bulletin

authors： Opgen-Rhein C,Neuhaus AH,Urbanek C,Hahn E,Sander T,Dettling M

更新日期：2008-11-01 00:00:00

abstract：:Data provided by case managers in community support programs are used to analyze the problems of families providing shelter to mentally ill relatives. Factors affecting complaints in 345 family households are contrasted with factors leading to complaints in a subsample of 622 other residential alternatives. Behavioral...

journal_title：Schizophrenia bulletin

authors： Gubman GD,Tessler RC,Willis G

更新日期：1987-01-01 00:00:00

abstract：:Genetic factors are known to influence both risk for schizophrenia (SZ) and variation in brain structure. A pressing question is whether the genetic underpinnings of brain phenotype and the disorder overlap. Using multivariate analytic methods and focusing on 1,402 common single-nucleotide polymorphisms (SNPs) mapped ...

journal_title：Schizophrenia bulletin

authors： Chen J,Calhoun VD,Lin D,Perrone-Bizzozero NI,Bustillo JR,Pearlson GD,Potkin SG,van Erp TGM,Macciardi F,Ehrlich S,Ho BC,Sponheim SR,Wang L,Stephen JM,Mayer AR,Hanlon FM,Jung RE,Clementz BA,Keshavan MS,Gershon ES,Sw

更新日期：2019-01-01 00:00:00

abstract：:Antipsychotic medications are viewed as cornerstones for both the short-term and long-term treatment of schizophrenia. However, evidence on long-term (10 or more years) efficacy of antipsychotics is mixed. Double-blind discontinuation studies indicate significantly more relapses in unmedicated schizophrenia patients i...

journal_title：Schizophrenia bulletin

authors： Harrow M,Jobe TH

更新日期：2013-09-01 00:00:00

abstract：:The Seventh International Congress on Schizophrenia Research was held in Santa Fe, New Mexico, in April 1999. This was the largest Congress meeting to date, with almost 1,000 presentations that covered all aspects of schizophrenia research. This article provides an account of the Congress proceedings. Several research...

journal_title：Schizophrenia bulletin

authors： Buckley PF,Buchanan RW,Tamminga CA,Schulz SC

更新日期：2000-01-01 00:00:00

abstract：:Antipsychotics, cognitive behavioral therapy (CBT), and omega-3-fatty acids have been found superior to control conditions as regards prevention of psychosis in people at-risk of first-episode psychosis. However, no large-scale trial evaluating the differential efficacy of CBT and antipsychotics has been performed yet...

journal_title：Schizophrenia bulletin

authors： Bechdolf A,Müller H,Stützer H,Wagner M,Maier W,Lautenschlager M,Heinz A,de Millas W,Janssen B,Gaebel W,Michel TM,Schneider F,Lambert M,Naber D,Brüne M,Krüger-Özgürdal S,Wobrock T,Riedel M,Klosterkötter J,PREVENT stu

更新日期：2011-09-01 00:00:00

abstract：:Persistent negative symptoms represent an alternative approach for assessing negative symptoms in the context of clinical trials. Persistent negative symptoms are designed to capture those symptoms that lead to functional impairment but are currently understudied and for which there are no currently available effectiv...

journal_title：Schizophrenia bulletin

authors： Buchanan RW

更新日期：2007-07-01 00:00:00

abstract：:Impaired attention is commonly observed among schizophrenia patients and those at genetic risk for the disease. This article reviews over 40 studies that used various versions of the Continuous Performance Test (CPT) as the primary measure of attention. These studies of normal subjects, affected patients, and various ...

journal_title：Schizophrenia bulletin

authors： Cornblatt BA,Keilp JG

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Adult patients having schizophrenia (SZ) or bipolar disorder (BP) may have in common neurocognitive deficits. Former evidence suggests impairments in several neuropsychological functions in young offspring at genetic risk for SZ or BP. Moreover, a dose-response relation may exist between the degree of famili...

journal_title：Schizophrenia bulletin

authors： Maziade M,Rouleau N,Gingras N,Boutin P,Paradis ME,Jomphe V,Boutin J,Létourneau K,Gilbert E,Lefebvre AA,Doré MC,Marino C,Battaglia M,Mérette C,Roy MA

更新日期：2009-09-01 00:00:00

abstract：:Self-experience anomalies are elementary features of schizophrenic pathology. Such deficits can have a profound impact on self-other relationship, but how they are related through aberrant brain function remains poorly understood. In this functional magnetic resonance imaging (fMRI) study, we provide new evidence for ...

journal_title：Schizophrenia bulletin

authors： Ebisch SJ,Mantini D,Northoff G,Salone A,De Berardis D,Ferri F,Ferro FM,Di Giannantonio M,Romani GL,Gallese V

更新日期：2014-09-01 00:00:00

abstract：:Abnormal reinforcement learning and representations of reward value are present in schizophrenia, and these impairments can manifest as deficits in risk/reward decision making. These abnormalities may be due in part to dopaminergic dysfunction within cortico-limbic-striatal circuitry. Evidence from studies with labora...

journal_title：Schizophrenia bulletin

authors： Stopper CM,Floresco SB

更新日期：2015-01-01 00:00:00

abstract：:Evaluations by families (of chronically mentally ill individuals) of mental health professionals and resources were solicited through a mail survey. The respondents, largely better educated, white, and female, indicated a generally high level of dissatisfaction. Emotional support, information, and aftercare resources ...

journal_title：Schizophrenia bulletin

authors： Holden DF,Lewine RR

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) implicate single nucleotide polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) region, as common risk factors for schizophrenia (SZ). Other studies implicate viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on S...

journal_title：Schizophrenia bulletin

authors： Bamne M,Wood J,Chowdari K,Watson AM,Celik C,Mansour H,Klei L,Gur RC,Bradford LD,Calkins ME,Santos AB,Edwards N,Kwentus J,McEvoy JP,Allen TB,Savage RM,Nasrallah HA,Gur RE,Perry RT,Go RC,Devlin B,Yolken R,Nimgao

更新日期：2012-11-01 00:00:00

abstract：:In light of the large number of studies published since the 2004 update of Schizophrenia Patient Outcomes Research Team psychopharmacological treatment recommendations, we conducted an extensive literature review to determine whether the current psychopharmacological treatment recommendations required revision and whe...

journal_title：Schizophrenia bulletin

authors： Buchanan RW,Kreyenbuhl J,Kelly DL,Noel JM,Boggs DL,Fischer BA,Himelhoch S,Fang B,Peterson E,Aquino PR,Keller W,Schizophrenia Patient Outcomes Research Team (PORT).

更新日期：2010-01-01 00:00:00

abstract：:Schizophrenia has been associated with heightened stress responsivity in adolescence that precedes onset of psychosis. We now report that multiple stressors during adolescence in normal rats leads to deficits in adults analogous to that seen in schizophrenia patients. Moreover, impairment of stress control by lesion o...

journal_title：Schizophrenia bulletin

authors： Gomes FV,Grace AA

更新日期：2017-05-01 00:00:00

abstract：:Cognitive deficits are a central feature of schizophrenia and occur in first-degree relatives of schizophrenic probands, even in the absence of psychotic symptoms. A number of cognitive domains have been implicated including measures of response inhibition and working memory. While the stability of cognitive deficits ...

journal_title：Schizophrenia bulletin

authors： Ross RG,Wagner B,Heinlein S,Zerbe GO

更新日期：2008-01-01 00:00:00

abstract：:Schizophrenia is a disorder of a neurodevelopmental origin manifested symptomatically after puberty. Structural neuroimaging studies show that neuroanatomical aberrations precede onset of symptoms, raising a question of whether schizophrenia can be prevented. Early treatment with atypical antipsychotics may reduce the...

journal_title：Schizophrenia bulletin

authors： Piontkewitz Y,Arad M,Weiner I

更新日期：2011-11-01 00:00:00

abstract：:This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...

journal_title：Schizophrenia bulletin

authors： Krausz M,Müller-Thomsen T

更新日期：1993-01-01 00:00:00