Abstract:
BACKGROUND:Adult patients having schizophrenia (SZ) or bipolar disorder (BP) may have in common neurocognitive deficits. Former evidence suggests impairments in several neuropsychological functions in young offspring at genetic risk for SZ or BP. Moreover, a dose-response relation may exist between the degree of familial loading and cognitive impairments. This study examines the cognitive functioning of high-risk (HR) offspring of parents having schizophrenia (HRSZ) and high-risk offspring of parents having bipolar disorder (HRBP) descending from densely affected kindreds. METHODS:The sample consisted of 45 young offspring (mean age of 17.3 years) born to a parent having SZ or BP descending from large multigenerational families of Eastern Québec that are densely affected by SZ or BP and followed up since 1989. The offspring were administered a lifetime best-estimate diagnostic procedure (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition [DSM-IV]) and an extensive standard neuropsychological battery. Raw scores were compared with age- and gender-matched controls. RESULTS:The offspring displayed differences in memory and executive functions when compared with controls. Moderate to large effect sizes (Cohen d) ranging from 0.65 to 1.25 (for IQ and memory) were observed. Several of the cognitive dysfunctions were present in both HRSZ and HRBP, even when considering DSM-IV clinical status. CONCLUSIONS:HRSZ and HRBP shared several aspects of their cognitive impairment. Our data suggest that the extremely high genetic and familial loading of these HRs may have contributed to a quantitatively increased magnitude of the cognitive impairments in both HR subgroups, especially in memory. These offspring at heightened risk present difficulties in processing information that warrant preventive research.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Maziade M,Rouleau N,Gingras N,Boutin P,Paradis ME,Jomphe V,Boutin J,Létourneau K,Gilbert E,Lefebvre AA,Doré MC,Marino C,Battaglia M,Mérette C,Roy MAdoi
10.1093/schbul/sbn058subject
Has Abstractpub_date
2009-09-01 00:00:00pages
919-30issue
5eissn
0586-7614issn
1745-1701pii
sbn058journal_volume
35pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Schizophrenia bulletin
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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pub_type: 评论,杂志文章
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更新日期:2010-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type:
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pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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