Improvements in negative symptoms and functional outcome after a new generation cognitive remediation program: a randomized controlled trial.

abstract：:Clinical descriptions of perceptual and attentional anomalies in schizophrenia emphasize phenomena such as flooding, or inundation, by sensory stimuli. A failure of sensory "gating" mechanisms in the brain is hypothesized to account for these symptoms, and this hypothesis has led to a marked interest in their putative...

journal_title：Schizophrenia bulletin

authors： Bunney WE Jr,Hetrick WP,Bunney BG,Patterson JV,Jin Y,Potkin SG,Sandman CA

更新日期：1999-01-01 00:00:00

abstract：:The literature on schizophrenia has reported a trend toward higher concordance rates for females in both monozygotic and dizygotic same-sexed twins. The validity of this finding is open to question. Rosenthal (1961 and 1962) pointed out that females are more likely than males to become inhabitants of chronic wards. Mo...

journal_title：Schizophrenia bulletin

authors： Samuels L

更新日期：1978-01-01 00:00:00

abstract：OBJECTIVE:Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22...

journal_title：Schizophrenia bulletin

authors： Vangkilde A,Olsen L,Hoeffding LK,Pedersen CB,Mortensen PB,Werge T,Trabjerg B

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) implicate single nucleotide polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) region, as common risk factors for schizophrenia (SZ). Other studies implicate viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on S...

journal_title：Schizophrenia bulletin

authors： Bamne M,Wood J,Chowdari K,Watson AM,Celik C,Mansour H,Klei L,Gur RC,Bradford LD,Calkins ME,Santos AB,Edwards N,Kwentus J,McEvoy JP,Allen TB,Savage RM,Nasrallah HA,Gur RE,Perry RT,Go RC,Devlin B,Yolken R,Nimgao

更新日期：2012-11-01 00:00:00

abstract：:We reported previously that residents of Greater Helsinki, Finland, whose mothers were exposed to the 1957 influenza epidemic during their second trimester of gestation had a significantly elevated risk of developing adult schizophrenia. The majority of the replication studies to date have not determined whether the m...

journal_title：Schizophrenia bulletin

authors： Mednick SA,Huttunen MO,Machón RA

更新日期：1994-01-01 00:00:00

abstract：INTRODUCTION:Separable, but positively correlated, factors emerge from analyses of cognitive test data in schizophrenia and control samples (eg, verbal memory and processing speed) and these factors guide data reduction. Additionally, data support a hierarchical model of cognitive performance, in which these correlatio...

journal_title：Schizophrenia bulletin

authors： Dickinson D,Goldberg TE,Gold JM,Elvevåg B,Weinberger DR

更新日期：2011-11-01 00:00:00

abstract：:Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been less cognitively impaired and less socially withdrawn in their premorbid life. Using a dataset comprising 948 patients wi...

journal_title：Schizophrenia bulletin

authors： Ferraro L,La Cascia C,Quattrone D,Sideli L,Matranga D,Capuccio V,Tripoli G,Gayer-Anderson C,Morgan C,Sami MB,Sham P,de Haan L,Velthorst E,Jongsma HE,Kirkbride JB,Rutten BPF,Richards AL,Roldan L,Arango C,Bernardo M,

更新日期：2020-04-10 00:00:00

abstract：:North American outcome studies of schizophrenia conducted within the past quarter century are reviewed if their minimum average followup is 10 years and they meet at least some modern design criteria. Ten such investigations are described and summarized. Taken as a whole, they demonstrate that schizophrenia can be a c...

journal_title：Schizophrenia bulletin

authors： McGlashan TH

更新日期：1988-01-01 00:00:00

abstract：:Neurological soft signs (NSS) are well documented in individuals with schizophrenia (SZ), yet so far, the relationship between NSS and specific symptom expression is unclear. We studied 76 SZ patients using magnetic resonance imaging (MRI) to determine associations between NSS, positive symptoms, gray matter volume (G...

journal_title：Schizophrenia bulletin

authors： Wolf RC,Rashidi M,Schmitgen MM,Fritze S,Sambataro F,Kubera KM,Hirjak D

更新日期：2020-10-24 00:00:00

abstract：:Hallucinations in children and adolescents are now known to occur on a continuum from healthy to psychopathology-related phenomena. Although hallucinations in young populations are mostly transient, they can cause substantial distress. Despite hallucinations being widely investigated, research so far has had limited i...

journal_title：Schizophrenia bulletin

authors： Maijer K,Hayward M,Fernyhough C,Calkins ME,Debbané M,Jardri R,Kelleher I,Raballo A,Rammou A,Scott JG,Shinn AK,Steenhuis LA,Wolf DH,Bartels-Velthuis AA

更新日期：2019-02-01 00:00:00

abstract：:Previous studies have reported associations between childhood adversities, eg, loss of a parent, being raised in institutional care, sexual and other kinds of abuse by adults and bullying by peers, and psychosis in adulthood. However, the mechanisms by which these adversities lead to psychotic experiences are poorly u...

journal_title：Schizophrenia bulletin

authors： Bentall RP,Wickham S,Shevlin M,Varese F

更新日期：2012-06-01 00:00:00

abstract：:Similarities in clinical course, age of onset, geographical distribution, and immunological responses of patients with schizophrenia and multiple sclerosis (MS) suggest that these two common illnesses of young adults may belong to a similar class of disorders. This review examines some of the similarities and differen...

journal_title：Schizophrenia bulletin

authors： Stevens JR

更新日期：1988-01-01 00:00:00

abstract：:The deficit syndrome is thought to characterize a pathophysiologically distinct subgroup of patients with schizophrenia. Supporting this notion, prior research examining the neuropsychological correlates of the deficit syndrome has suggested the presence of a differential impairment in frontal and parietal functions. ...

journal_title：Schizophrenia bulletin

authors： Cohen AS,Saperstein AM,Gold JM,Kirkpatrick B,Carpenter WT Jr,Buchanan RW

更新日期：2007-09-01 00:00:00

abstract：:Studies on the long-term development and early predictors of treatment-resistant schizophrenia (TRS) and clozapine-resistant TRS (CR-TRS) in patients with first-episode schizophrenia-spectrum disorders (FES) are limited and have not considered the impact of early intervention services (EIS). This study aimed to explor...

journal_title：Schizophrenia bulletin

authors： Chan SKW,Chan HYV,Honer WG,Bastiampillai T,Suen YN,Yeung WS,Lam M,Lee WK,Ng RMK,Hui CLM,Chang WC,Lee EHM,Chen EYH

更新日期：2020-10-12 00:00:00

abstract：:A number of recent articles, many appearing in Schizophrenia Bulletin, signal a renewed interest in phenomenological approaches to our understanding of schizophrenia. These approaches conceptualize schizophrenia as a disorder of altered self-awareness and decreased prereflective social attunement, which may manifest a...

journal_title：Schizophrenia bulletin

authors： Nour MM,Barrera A

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Embodied emotions arise from interoceptive and somatosensory processes, and are essential to the development of a stable sense of self. Emotional embodiment is therefore inherently interwoven with our sense of bodily self-awareness, and allows us to navigate complex social situations. Given that the core feat...

journal_title：Schizophrenia bulletin

authors： Torregrossa LJ,Snodgress MA,Hong SJ,Nichols HS,Glerean E,Nummenmaa L,Park S

更新日期：2019-09-11 00:00:00

abstract：:Abnormal reinforcement learning and representations of reward value are present in schizophrenia, and these impairments can manifest as deficits in risk/reward decision making. These abnormalities may be due in part to dopaminergic dysfunction within cortico-limbic-striatal circuitry. Evidence from studies with labora...

journal_title：Schizophrenia bulletin

authors： Stopper CM,Floresco SB

更新日期：2015-01-01 00:00:00

abstract：:This study compared the performance of 39 biological relatives of persons with schizophrenia to that of 30 normal adult controls on graphesthesia processing, a complex somatosensory processing task. The relatives performed significantly worse on the graphesthesia task compared to the healthy controls. The relatives an...

journal_title：Schizophrenia bulletin

authors： Chang BP,Lenzenweger MF

更新日期：2004-01-01 00:00:00

abstract：:We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neuroin...

journal_title：Schizophrenia bulletin

authors： Mirsky AF,Kugelmass S,Ingraham LJ,Frenkel E,Nathan M

更新日期：1995-01-01 00:00:00

abstract：:Educating the public that mental illness is a brain disease is a popular strategy for combating mental illness stigma. Evidence suggests that while such an approach reduces blame for mental illness, it may unintentionally exacerbate other components of stigma, particularly the benevolence and dangerousness stigmas. Co...

journal_title：Schizophrenia bulletin

authors： Corrigan PW,Watson AC

更新日期：2004-01-01 00:00:00

abstract：:Visual illusions allow for strong tests of perceptual functioning. Perceptual impairments can produce superior task performance on certain tasks (i.e., more veridical perception), thereby avoiding generalized deficit confounds while tapping mechanisms that are largely outside of conscious control. Using a task based o...

journal_title：Schizophrenia bulletin

authors： Horton HK,Silverstein SM

更新日期：2011-07-01 00:00:00

abstract：:Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural...

journal_title：Schizophrenia bulletin

authors： Hirjak D,Kubera KM,Northoff G,Fritze S,Bertolino AL,Topor CE,Schmitgen MM,Wolf RC

更新日期：2019-10-24 00:00:00

abstract：:Empirically supported treatments for schizophrenia now include a variety of psychosocial interventions, such as social skills training, vocational rehabilitation, and psychotherapy. As awareness of the functional importance of neurocognitive impairments in schizophrenia has increased, interest in treatments to improve...

journal_title：Schizophrenia bulletin

authors： Twamley EW,Jeste DV,Bellack AS

更新日期：2003-01-01 00:00:00

abstract：:To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating hippocampal functional connectivity during resting state, using seeds prescribed in its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (S...

journal_title：Schizophrenia bulletin

authors： Kraguljac NV,White DM,Hadley N,Hadley JA,Ver Hoef L,Davis E,Lahti AC

更新日期：2016-07-01 00:00:00

abstract：:This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...

journal_title：Schizophrenia bulletin

authors： Krausz M,Müller-Thomsen T

更新日期：1993-01-01 00:00:00

abstract：:Thirty psychiatric inpatients each rated their relationship with their auditory hallucination using the Structural Analysis of Social Behavior questionnaires which assess partnerships in terms of interpersonal focus, love-hate, and enmeshment-differentiation. Results showed that all subjects had integrated, interperso...

journal_title：Schizophrenia bulletin

authors： Benjamin LS

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Patients with deficit schizophrenia differ from nondeficit patients with schizophrenia relative to several neurobiological correlates and relative to the risk factors of family history and season of birth. Exposure to human herpesviruses is a possible risk factor for schizophrenia. We hypothesized that there...

journal_title：Schizophrenia bulletin

authors： Dickerson F,Kirkpatrick B,Boronow J,Stallings C,Origoni A,Yolken R

更新日期：2006-04-01 00:00:00

abstract：:Research on the effectiveness of short-term education programs in changing societal attitudes about mental illness has been mixed. Education efforts seem to be mediated by characteristics of the program participants. This study determines whether the effects of a specially prepared, semester-long course on severe ment...

journal_title：Schizophrenia bulletin

authors： Holmes EP,Corrigan PW,Williams P,Canar J,Kubiak MA

更新日期：1999-01-01 00:00:00

abstract：:The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms ...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Douglas MS,Bellack AS,Morrison RL

更新日期：1991-01-01 00:00:00

abstract：:Remitting illness such as affective or schizoaffective disorder is appropriately described by a vulnerability model. Clinical evidence is reviewed here to clarify the relationship between the affective-disorder-like and schizophrenia-like symptoms in a schizoaffective episode. A model is proposed which treats vulnerab...

journal_title：Schizophrenia bulletin

authors： Braden W

更新日期：1984-01-01 00:00:00