Abstract:
:Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been less cognitively impaired and less socially withdrawn in their premorbid life. Using a dataset comprising 948 patients with first-episode psychosis (FEP) and 1313 population controls across 6 countries, we examined the extent to which IQ and both early academic (Academic Factor [AF]) and social adjustment (Social Factor [SF]) are related to the lifetime frequency of cannabis use in both patients and controls. We expected a higher IQ and a better premorbid social adjustment in psychotic patients who had ever used cannabis compared to patients without any history of use. We did not expect such differences in controls. In both patients and controls, IQ was 3 points higher among occasional-users than in never-users (mean difference [Mdiff] = 2.9, 95% CI = [1.2, 4.7]). Both cases and control daily-users had lower AF compared to occasional (Mdiff = -0.3, 95% CI = [-0.5; -0.2]) and never-users (Mdiff = -0.4, 95% CI = [-0.6; -0.2]). Finally, patient occasional (Mdiff = 0.3, 95% CI = [0.1; 0.5]) and daily-users (Mdiff = 0.4, 95% CI = [0.2; 0.6]) had better SF than their never-using counterparts. This difference was not present in controls (Fgroup*frequency(2, 2205) = 4.995, P = .007). Our findings suggest that the better premorbid social functioning of FEP with a history of cannabis use may have contributed to their likelihood to begin using cannabis, exposing them to its reported risk-increasing effects for Psychotic Disorders.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Ferraro L,La Cascia C,Quattrone D,Sideli L,Matranga D,Capuccio V,Tripoli G,Gayer-Anderson C,Morgan C,Sami MB,Sham P,de Haan L,Velthorst E,Jongsma HE,Kirkbride JB,Rutten BPF,Richards AL,Roldan L,Arango C,Bernardo M,doi
10.1093/schbul/sbz077subject
Has Abstractpub_date
2020-04-10 00:00:00pages
517-529issue
3eissn
0586-7614issn
1745-1701pii
5540368journal_volume
46pub_type
杂志文章abstract::In response to my discussion of sex differences in concordance rates for schizophrenia in twins, Lewine (1979) noted that male schizophrenics are hospitalized earlier than females. He questioned whether females had been followed through the risk period. To clarify, I calculated the age at followup of discordant twins ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/5.1.8
更新日期:1979-01-01 00:00:00
abstract::Psychiatric research, including the search for predisposing genes, has tended to proceed under the assumptions that schizophrenia and bipolar disorder, as defined in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and International Statistical Classification of Diseases, 10th Revision, are discr...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm053
更新日期:2007-07-01 00:00:00
abstract::Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects par...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbu115
更新日期:2015-03-01 00:00:00
abstract::Recently published data from the Roscommon Family Study show that a parental diagnosis of schizotypal disorder (SPD) has a significant and specific impact on the risk for schizophrenia in siblings of index probands with schizophrenia spectrum disorders. The distribution patterns of risks for schizophrenia and SPD in p...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/22.2.191
更新日期:1996-01-01 00:00:00
abstract::Schizophrenia patients have higher scores on neurological soft-signs (NSS) and show greater deficits on a variety of neuropsychological tests than normal control subjects and mixed groups of psychiatric patients. Among chronic schizophrenia patients it is unclear which of these types of deficits most strongly differen...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033421
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:Over the past 30 years, illness management programs and cognitive-behavioral therapy for psychosis have gained prominence in the treatment of schizophrenia. However, little is known about the long-term benefits of these types of programs when delivered during inpatient treatment following a symptom exacerbati...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,随机对照试验
doi:10.1093/schbul/sbw032
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Adolescence can be a challenging time, characterized by self-consciousness, heightened regard for peer acceptance, and fear of rejection. Interpersonal concerns are amplified by unpredictable social interactions, both online and offline. This developmental and social context is potentially conducive to the e...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sby180
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:Cigarette smoking was consistently found to be more prevalent in individuals with schizophrenia than in other psychiatric groups and the general population. These findings have been interpreted as evidence of a specific association between schizophrenia and smoking. However, the supporting data come primaril...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbn066
更新日期:2010-01-01 00:00:00
abstract::Schizophrenia is but one form of psychosis; therefore, it is important to control for the psychotic factor in studies of the schizophrenic syndrome. A survey was done of 478 articles in 15 major psychiatric and psychological journals to determine the frequency of controls for psychosis in schizophrenia research. The s...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/7.4.729
更新日期:1981-01-01 00:00:00
abstract::Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of a number of bioactive molecules; of principal interest to psychiatry, these include dopamine. The enzyme is encoded by the COMT gene. COMT is located (along with 47 other genes) in a fragment of chromosome 22q11 which when delete...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm019
更新日期:2007-05-01 00:00:00
abstract::Phenotypic heterogeneity within patients and controls may explain why the genetic variants contributing to schizophrenia risk explain only a fraction of the heritability. The aim of this study is to investigate quantitative and qualitative differences in psychosis symptoms in a sample including psychosis patients, the...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbq103
更新日期:2012-05-01 00:00:00
abstract::Psychophysiological anomalies in symptomatic schizophrenic patients, remitted schizophrenic patients, and individuals at heightened risk for a schizophrenic disorder are reviewed with an emphasis on electrodermal anomalies. Two electrodermal anomalies are identified in different subgroups of symptomatic patients: (1) ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/10.2.204
更新日期:1984-01-01 00:00:00
abstract::To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating hippocampal functional connectivity during resting state, using seeds prescribed in its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (S...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbv228
更新日期:2016-07-01 00:00:00
abstract::The left superior temporal sulcus (STS) plays an important role in integrating audiovisual information and is functionally connected to disparate regions of the brain. For the integration of gesture information in an abstract sentence context (metaphoric gestures), intact connectivity between the left STS and the infe...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbt110
更新日期:2014-07-01 00:00:00
abstract::The deficit syndrome is thought to characterize a pathophysiologically distinct subgroup of patients with schizophrenia. Supporting this notion, prior research examining the neuropsychological correlates of the deficit syndrome has suggested the presence of a differential impairment in frontal and parietal functions. ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析,评审
doi:10.1093/schbul/sbl066
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Deficits in emotion processing are thought to underlie the key negative symptoms flat affect and anhedonia observed in psychotic disorders. This study investigated emotional experience and social behavior in the realm of daily life in a sample of patients with schizophrenia and schizoaffective disorder, stra...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr137
更新日期:2013-01-01 00:00:00
abstract::Social cognitive impairments and negative symptoms are core features of schizophrenia closely associated with impaired community functioning. However, little is known about whether these are independent dimensions of illness and if so, whether individuals with schizophrenia can be meaningfully classified based on thes...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr125
更新日期:2013-01-01 00:00:00
abstract::In this issue we have tried to bring together a series of reviews describing new developments in the pharmacologic management of schizophrenia. Important progress is being made not only in medication development, but also in furthering our ability to use available treatments and treatment combinations in the most effe...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/17.2.193
更新日期:1991-01-01 00:00:00
abstract::Although there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinic...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sby113
更新日期:2019-06-18 00:00:00
abstract::We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neuroin...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/21.2.227
更新日期:1995-01-01 00:00:00
abstract::In addition to introducing the six articles joined by our thematic outlook, this article addresses the importance of subcortical structures as they may be related to information processing and the life experience of schizophrenic patients. This is a heuristic exercise aimed at bridging the conceptual gaps between clin...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/13.4.555
更新日期:1987-01-01 00:00:00
abstract::Identifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions. This article presents a selective review of findings on risk prediction algorithms and potential mechanisms of onset in youth at clinical high-risk for ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbv173
更新日期:2016-07-01 00:00:00
abstract::The study of sexual dimorphism in brain morphology may help delineate subtypes of schizophrenia based, in part, on sex; yield insight into the relationship between brain structure and behavior; and provide a neurodevelopmental context for studying the ontogenesis of schizophrenia. Preliminary findings from an ongoing ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/16.2.195
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in sc...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbr101
更新日期:2013-01-01 00:00:00
abstract::Remitting illness such as affective or schizoaffective disorder is appropriately described by a vulnerability model. Clinical evidence is reviewed here to clarify the relationship between the affective-disorder-like and schizophrenia-like symptoms in a schizoaffective episode. A model is proposed which treats vulnerab...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/10.1.71
更新日期:1984-01-01 00:00:00
abstract::The literature on schizophrenia has reported a trend toward higher concordance rates for females in both monozygotic and dizygotic same-sexed twins. The validity of this finding is open to question. Rosenthal (1961 and 1962) pointed out that females are more likely than males to become inhabitants of chronic wards. Mo...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/4.1.14
更新日期:1978-01-01 00:00:00
abstract::Kraepelin said severe mental illness was due to 2 diseases subsequently characterized as disorders of thought vs disorders of mood, ie, the Kraepelinian dichotomy. Schizophrenia, traditionally considered the disorder of thought, has been defined by the presence of hallucinations, delusions, catatonia, and disorganizat...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm035
更新日期:2008-01-01 00:00:00
abstract::Mobile assessment techniques have been used for nearly 3 decades in mental health research, including in investigations of individuals with schizophrenia and other severe disorders. This article reviews the benefits of these data collection strategies relative to traditional self-report or clinician-administered measu...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbr186
更新日期:2012-05-01 00:00:00
abstract::The New York High-Risk Project began in 1971 as a prospective, longitudinal study of (1) children of one or two schizophrenic parents and (2) comparison groups of children whose parents had other or no psychiatric disorders. The former were examined because they were known to be at high risk--some 10-25 percent for ch...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/13.3.451
更新日期:1987-01-01 00:00:00
abstract::Similarities in clinical course, age of onset, geographical distribution, and immunological responses of patients with schizophrenia and multiple sclerosis (MS) suggest that these two common illnesses of young adults may belong to a similar class of disorders. This review examines some of the similarities and differen...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/14.2.231
更新日期:1988-01-01 00:00:00