Abstract:
:Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects participated: 27 healthy controls (CTRL) and 33 at ultrahigh risk (UHR) for psychosis. At baseline, cortical responses during a verbal fluency task were measured using functional Magnetic Resonance Imaging (fMRI) and proton Magnetic Resonance Spectroscopy (1H-MRS) was used to measure thalamic glutamate levels. The UHR subjects were then followed clinically for a mean duration of 18 months, and subdivided into "good" and "poor" functional outcome subgroups according to their Global Assessment of Function score at follow-up. UHR subjects with a poor functional outcome showed greater cortical and subcortical activation than UHR subjects with a good functional outcome. They also had lower levels of thalamic glutamate and showed a negative relationship between thalamic glutamate levels and prefrontal-striatal activation that was not present in the good functional outcome or control groups. In people at high risk for psychosis, their subsequent level of functioning may depend on the extent to which neurophysiological and neurochemical function is perturbed when they first present to clinical services.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Allen P,Chaddock CA,Egerton A,Howes OD,Barker G,Bonoldi I,Fusar-Poli P,Murray R,McGuire Pdoi
10.1093/schbul/sbu115subject
Has Abstractpub_date
2015-03-01 00:00:00pages
429-39issue
2eissn
0586-7614issn
1745-1701pii
sbu115journal_volume
41pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1093/schbul/8.4.626
更新日期:1982-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,随机对照试验
doi:10.1093/schbul/sbw032
更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析,评审
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更新日期:2013-03-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbn066
更新日期:2010-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbt087
更新日期:2014-05-01 00:00:00
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doi:10.1093/schbul/6.3.490
更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a007095
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pub_type: 杂志文章,随机对照试验
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更新日期:2020-07-08 00:00:00
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pub_type: 杂志文章
doi:10.1093/schbul/sbi052
更新日期:2006-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/sbn069
更新日期:2010-03-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/16.2.195
更新日期:1990-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,评审
doi:10.1093/schbul/sbm035
更新日期:2008-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/schbul/22.4.659
更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/schbul/sbz031
更新日期:2020-01-04 00:00:00
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pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.schbul.a033320
更新日期:1998-01-01 00:00:00