The genetic deconstruction of psychosis.

abstract：:An important development in cognitive remediation of schizophrenia is a focus on motivation. However, following a distinction between the concepts of intrinsic motivation (IM) and extrinsic motivation, discussions of IM-based methods have downplayed or misrepresented the role that extrinsic rewards can, and actually d...

journal_title：Schizophrenia bulletin

authors： Silverstein SM

更新日期：2010-09-01 00:00:00

abstract：:Psychobiological research in child psychiatry requires rigorous assessment of behavior and multiple perspectives on brain function through neurochemical, neuroendocrine, psychophysiological, and other advanced methods. The serious neuropsychiatric disorders of childhood, such as autism, attention deficit disorder, and...

journal_title：Schizophrenia bulletin

authors： Young JG,Cohen DJ,Shaywitz SE,Caparulo BK,Kavanagh ME,Hunt RD,Leckman JF,Anderson GM,Detlor J,Harcherik D,Shaywitz BA

更新日期：1982-01-01 00:00:00

abstract：:The prevalence and demographic and clinical correlates of lifetime substance use disorders were examined in a cohort of 325 recently hospitalized psychiatric patients (53% schizophrenia or schizoaffective disorder). Alcohol use was the most common type of substance use disorder, followed by cannabis and cocaine use. U...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Yarnold PR,Rosenberg SD,Swett C Jr,Miles KM,Hill D

更新日期：2000-01-01 00:00:00

abstract：:The two indices that have been proposed for quantifying the accuracy of smooth-following eye movements are shown to be interchangeable. This algebraic fact will permit comparability of values between laboratories only if workers who employ the signal-to-noise ratio (S/N) as their index measure S and N as the total sig...

journal_title：Schizophrenia bulletin

authors： Lykken DT,Iacono WG,Lykken JD

更新日期：1981-01-01 00:00:00

abstract：:Problems in psychiatric classification have impeded research into psychopathology for more than a century. Here, I briefly review several new approaches to solving this problem, including the internalizing-externalizing-psychosis spectra, the 5-factor model of psychotic symptoms, and the more recent network approach. ...

journal_title：Schizophrenia bulletin

authors： Bentall RP

更新日期：2014-07-01 00:00:00

abstract：:There is some evidence that schizotypal traits are related to a genetic or familial liability to develop schizophrenia. However, it is unclear whether the number of schizotypal traits is elevated in parents of schizophrenia patients compared with controls. This study used the Schizotypal Personality Questionnaire to i...

journal_title：Schizophrenia bulletin

authors： Appels MC,Sitskoorn MM,Vollema MG,Kahn RS

更新日期：2004-01-01 00:00:00

abstract：:Similarities in clinical course, age of onset, geographical distribution, and immunological responses of patients with schizophrenia and multiple sclerosis (MS) suggest that these two common illnesses of young adults may belong to a similar class of disorders. This review examines some of the similarities and differen...

journal_title：Schizophrenia bulletin

authors： Stevens JR

更新日期：1988-01-01 00:00:00

abstract：:At the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) New Approaches Conference, a discussion group focused on directions for future research that are critical to enhancing our understanding of the distinctions among key cognitive domains that have relevance for the development of c...

journal_title：Schizophrenia bulletin

authors： Nuechterlein KH,Robbins TW,Einat H

更新日期：2005-10-01 00:00:00

abstract：:The design of the Positive and Negative Syndrome Scale (PANSS) with item levels ranging from 1 to 7 leads to the trivial result that the 30-item scale's zero level (no symptoms) is 30. This causes serious problems when ratios are calculated which always implicitly depend on a natural zero point (equals 0). Recent publ...

journal_title：Schizophrenia bulletin

authors： Obermeier M,Mayr A,Schennach-Wolff R,Seemüller F,Möller HJ,Riedel M

更新日期：2010-05-01 00:00:00

abstract：:Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to non...

journal_title：Schizophrenia bulletin

authors： Egerton A,Howes OD,Houle S,McKenzie K,Valmaggia LR,Bagby MR,Tseng HH,Bloomfield MA,Kenk M,Bhattacharyya S,Suridjan I,Chaddock CA,Winton-Brown TT,Allen P,Rusjan P,Remington G,Meyer-Lindenberg A,McGuire PK,Mizrahi R

更新日期：2017-03-01 00:00:00

abstract：:One of the leading theories of the neuropathology of schizophrenia is that it is a developmental disorder of "neural connectivity." To assess this theory, it is first necessary to understand how precise neural connections normally are established. Sensory-driven neural activity has been widely recognized as crucial fo...

journal_title：Schizophrenia bulletin

authors： Penn AA

更新日期：2001-01-01 00:00:00

abstract：:Hallucinations in children and adolescents are now known to occur on a continuum from healthy to psychopathology-related phenomena. Although hallucinations in young populations are mostly transient, they can cause substantial distress. Despite hallucinations being widely investigated, research so far has had limited i...

journal_title：Schizophrenia bulletin

authors： Maijer K,Hayward M,Fernyhough C,Calkins ME,Debbané M,Jardri R,Kelleher I,Raballo A,Rammou A,Scott JG,Shinn AK,Steenhuis LA,Wolf DH,Bartels-Velthuis AA

更新日期：2019-02-01 00:00:00

abstract：:This article examines the factors that influence antipsychotic use among youth treated in public inpatient facilities. By combining data from 11 focus groups, a survey of 43 researchers and clinicians, and a chart review of 100 closed patient charts, we investigated the interplay between physicians' and staff members'...

journal_title：Schizophrenia bulletin

authors： Pappadopulos E,Jensen PS,Schur SB,MacIntyre JC 2nd,Ketner S,Van Orden K,Sverd J,Sardana S,Woodlock D,Schweitzer R,Rube D

更新日期：2002-01-01 00:00:00

abstract：:Although schizophrenia affects a number of brain regions and produces a range of clinical symptoms, we believe its origins lie at the level of single neurons and simple networks. Owing to this, as well as to its high degree of heritability, we hypothesize that schizophrenia is amenable to cell-based studies in vitro. ...

journal_title：Schizophrenia bulletin

authors： Tran NN,Ladran IG,Brennand KJ

更新日期：2013-01-01 00:00:00

abstract：:A frontostriatal hypothesis of schizophrenia is advanced which takes into account evidence from studies of neurochemical pathology, functional imaging, cognitive neuropsychology, and experimental and clinical psychopharmacology, in addition to factor analyses of the symptomatic heterogeneity of this disorder. This evi...

journal_title：Schizophrenia bulletin

authors： Robbins TW

更新日期：1990-01-01 00:00:00

abstract：:In addition to introducing the six articles joined by our thematic outlook, this article addresses the importance of subcortical structures as they may be related to information processing and the life experience of schizophrenic patients. This is a heuristic exercise aimed at bridging the conceptual gaps between clin...

journal_title：Schizophrenia bulletin

authors： Patterson T

更新日期：1987-01-01 00:00:00

abstract：:Thirty psychiatric inpatients each rated their relationship with their auditory hallucination using the Structural Analysis of Social Behavior questionnaires which assess partnerships in terms of interpersonal focus, love-hate, and enmeshment-differentiation. Results showed that all subjects had integrated, interperso...

journal_title：Schizophrenia bulletin

authors： Benjamin LS

更新日期：1989-01-01 00:00:00

abstract：:Kraepelin said severe mental illness was due to 2 diseases subsequently characterized as disorders of thought vs disorders of mood, ie, the Kraepelinian dichotomy. Schizophrenia, traditionally considered the disorder of thought, has been defined by the presence of hallucinations, delusions, catatonia, and disorganizat...

journal_title：Schizophrenia bulletin

authors： Raymond Lake C

更新日期：2008-01-01 00:00:00

abstract：:The authors describe an easily administered scale being developed to assess the rejecting feelings of family respondents toward former mental patients who return to live with their families. Based upon a sample of 133 discharged mental patients and family members, the scale demonstrates a moderately high reliability (...

journal_title：Schizophrenia bulletin

authors： Kreisman DE,Simmens SJ,Joy VD

更新日期：1979-01-01 00:00:00

abstract：:This meta-analytic review sought to answer questions concerning the role of psychosocial treatments in the comprehensive management of patients with schizophrenia. The review focused on the effects of combining psychosocial treatment with somatic treatment. Findings demonstrated the additive and supplementary effects ...

journal_title：Schizophrenia bulletin

authors： Mojtabai R,Nicholson RA,Carpenter BN

更新日期：1998-01-01 00:00:00

abstract：:The poverty and lack of social role in the lives of many people with schizophrenia seem similar to those of people in long-term unemployment, raising the possibility that there may be some commonalities in their time use and community functioning. To test this possibility, the social anxiety, time use, and activity pa...

journal_title：Schizophrenia bulletin

authors： Hayes RL,Halford WK

更新日期：1996-01-01 00:00:00

abstract：:We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neuroin...

journal_title：Schizophrenia bulletin

authors： Mirsky AF,Kugelmass S,Ingraham LJ,Frenkel E,Nathan M

更新日期：1995-01-01 00:00:00

abstract：:Staff members from nine mental health agencies were trained in psychiatric rehabilitation technology. The trainers then received intensive followup to assist them in implementing the technology in their own agencies. Evaluation of the impact of the "training of trainers" strategy suggested that mental health workers w...

journal_title：Schizophrenia bulletin

authors： Rogers ES,Cohen BF,Danley KS,Hutchinson D,Anthony WA

更新日期：1986-01-01 00:00:00

abstract：:Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest fu...

journal_title：Schizophrenia bulletin

authors： Prasad KM,Keshavan MS

更新日期：2008-07-01 00:00:00

abstract：:Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. Drug-free schiz...

journal_title：Schizophrenia bulletin

authors： Jin Y,Potkin SG,Rice D,Sramek J,Costa J,Isenhart R,Heh C,Sandman CA

更新日期：1990-01-01 00:00:00

abstract：:Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained attention in schizophrenia patients, although its neural mechanisms are unknown. Understanding the neural basis of this effect may lead to new treatment strategies for this cognitiv...

journal_title：Schizophrenia bulletin

authors： Hong LE,Schroeder M,Ross TJ,Buchholz B,Salmeron BJ,Wonodi I,Thaker GK,Stein EA

更新日期：2011-03-01 00:00:00

abstract：:Cognitive remediation is a behavioral intervention designed to improve cognition in people who have suffered a decline in neuropsychological functioning. The application of cognitive remediation for people with schizophrenia has become increasingly popular. In this article we attempt to determine what factors moderate...

journal_title：Schizophrenia bulletin

authors： Medalia A,Richardson R

更新日期：2005-10-01 00:00:00

abstract：:The electroencephalogram (EEG) recorded from the human scalp is widely used to study cognitive and brain functions in schizophrenia. Current research efforts are primarily devoted to the assessment of event-related potentials (ERPs) and event-related oscillations (EROs), extracted from the ongoing EEG, in patients wit...

journal_title：Schizophrenia bulletin

authors： van der Stelt O,Belger A

更新日期：2007-07-01 00:00:00

abstract：:Increased latency of stimulus encoding is presented as a central deficit in schizophrenia cognition. Encoding, here, entails the internal representation of presenting stimuli in a format facilitating their implementation in other cognitive processes, such as those taking place in working memory. Historical roots of su...

journal_title：Schizophrenia bulletin

authors： Neufeld RW

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Emotion dysregulation is crucial to both poor social functioning and psychotic symptom formation in patients with schizophrenia. The efficient use of emotion regulation strategies, such as cognitive reappraisal, has been less frequently observed in the early phases of psychotic disorder. It is unknown whethe...

journal_title：Schizophrenia bulletin

authors： Kim M,Hwang WJ,Park J,Kim T,Oh S,Kwon JS

更新日期：2021-01-23 00:00:00