Effect of DISC1 on the P300 waveform in psychosis.

Abstract:

INTRODUCTION:Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in schizophrenia. METHODS:We examined the role of variation in DISC1 polymorphisms on the P300 endophenotype in a large sample of patients with schizophrenia or psychotic bipolar disorder (n = 149), their unaffected relatives (n = 130), and unrelated healthy controls (n = 208) using linear regression and haplotype analysis. RESULTS:Significant associations between P300 amplitude and latency and DISC1 polymorphisms/haplotypes were found. Those homozygous for the A allele of single-nucleotide polymorphism (SNP) rs821597 displayed significantly reduced P300 amplitudes in comparison with homozygous for the G allele (P = .009) and the heterozygous group (P = .018). Haplotype analysis showed a significant association for DISC1 haplotypes (rs3738401|rs6675281|rs821597|rs821616|rs967244|rs980989) and P300 latency. Haplotype GCGTCG and ACGTTT were associated with shorter latencies. DISCUSSION:The P300 waveform appears to be modulated by variation in individual SNPs and haplotypes of DISC1. Because DISC1 is involved in neurodevelopment, one hypothesis is that disruption in neural connectivity impairs cognitive processes illustrated by P300 deficits observed in this sample.

journal_name

Schizophr Bull

journal_title

Schizophrenia bulletin

authors

Shaikh M,Hall MH,Schulze K,Dutt A,Li K,Williams I,Walshe M,Constante M,Broome M,Picchioni M,Toulopoulou T,Collier D,Stahl D,Rijsdijk F,Powell J,Murray RM,Arranz M,Bramon E

doi

10.1093/schbul/sbr101

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

161-7

issue

1

eissn

0586-7614

issn

1745-1701

pii

sbr101

journal_volume

39

pub_type

杂志文章
  • Comorbid Major Depressive Disorder in Schizophrenia: A Systematic Review and Meta-Analysis.

    abstract::Comorbid major depressive disorder (MDD) in schizophrenia (SZ; SZ-MDD) has been identified as a major prognostic factor. However, the prevalence and associated factors of SZ-MDD have never been explored in a meta-analysis. All studies assessing the prevalence of SZ-MDD in stabilized outpatients with a standardized sca...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbaa153

    authors: Etchecopar-Etchart D,Korchia T,Loundou A,Llorca PM,Auquier P,Lançon C,Boyer L,Fond G

    更新日期:2020-11-30 00:00:00

  • Financial capacity in persons with schizophrenia and serious mental illness: clinical and research ethics aspects.

    abstract::In contrast with issues of consent capacity, financial capacity has received surprisingly little clinical or ethical attention in the psychiatric literature. Issues of financial capacity emerge frequently regarding clients with serious mental illness (SMI), and their resolution has practical and ethical significance f...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbj027

    authors: Marson DC,Savage R,Phillips J

    更新日期:2006-01-01 00:00:00

  • Family treatment of adult schizophrenic patients: a psycho-educational approach.

    abstract::As part of a long-term study in schizophrenia, a model of family intervention has been developed which attempts to diminish relapse rates of schizophrenic patients. This model reflects theoretical and research findings which suggest that certain patients have a "core psychological deficit" that might increase vulnerab...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/6.3.490

    authors: Anderson CM,Hogarty GE,Reiss DJ

    更新日期:1980-01-01 00:00:00

  • Psychotic spectrum disorders and alcohol abuse: a review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram.

    abstract::The rate of substance-use disorders in patients with mental illnesses within the psychotic spectrum, such as schizophrenia, schizoaffective disorder, and bipolar disorder, is higher than the rate observed in the general population and is associated with significant morbidity and mortality. Although there are currently...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/schbul/sbl010

    authors: Petrakis IL,Nich C,Ralevski E

    更新日期:2006-10-01 00:00:00

  • NMDA receptor and schizophrenia: a brief history.

    abstract::Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schi...

    journal_title:Schizophrenia bulletin

    pub_type: 历史文章,杂志文章

    doi:10.1093/schbul/sbs076

    authors: Coyle JT

    更新日期:2012-09-01 00:00:00

  • Deficit schizophrenia: association with serum antibodies to cytomegalovirus.

    abstract:BACKGROUND:Patients with deficit schizophrenia differ from nondeficit patients with schizophrenia relative to several neurobiological correlates and relative to the risk factors of family history and season of birth. Exposure to human herpesviruses is a possible risk factor for schizophrenia. We hypothesized that there...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbi054

    authors: Dickerson F,Kirkpatrick B,Boronow J,Stallings C,Origoni A,Yolken R

    更新日期:2006-04-01 00:00:00

  • First person account: the Messiah quest.

    abstract::The article that begins below is the fifth in a series of personal accounts to be published in the Schizophrenia Bulletin. In describing his account, the author commented: "The viewpoint is solely my consciousness. The substance of every statement and the specific words in many statements actually occurred to me. Thir...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/7.3.527

    authors: Zelt D

    更新日期:1981-01-01 00:00:00

  • The Relationship Between Clinical and Personal Recovery in Patients With Schizophrenia Spectrum Disorders: A Systematic Review and Meta-analysis.

    abstract::Patients describe experiencing personal recovery despite ongoing symptoms of psychosis. The aim of the current research was to perform a meta-analysis investigating the relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders. A comprehensive OvidSP database search was perf...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/schbul/sbx088

    authors: Van Eck RM,Burger TJ,Vellinga A,Schirmbeck F,de Haan L

    更新日期:2018-04-06 00:00:00

  • Ventricle-to-brain ratio and symptoms at the onset of first-break schizophrenia.

    abstract::Ventricle-to-brain ratio (VBR) was measured from the computed tomographic (CT) scans of 33 very recent-onset psychotic patients. Illness severity and positive and negative symptoms were also assessed in 21 of these patients with schizophreniform disorder. Forty-five neurology patients served as controls. Analyses reve...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/18.3.427

    authors: Holsenbeck LS 3rd,Davidson LM,Hostetter RE,Casanova MF,Taylor DO,Kelley CT,Perrotta C Jr,Borison RL,Diamond B

    更新日期:1992-01-01 00:00:00

  • Schizophrenia with onset in adolescence: an 11-year followup.

    abstract::This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/19.4.831

    authors: Krausz M,Müller-Thomsen T

    更新日期:1993-01-01 00:00:00

  • Assessment of brain function in clinical pediatric research: behavioral and biological strategies.

    abstract::Psychobiological research in child psychiatry requires rigorous assessment of behavior and multiple perspectives on brain function through neurochemical, neuroendocrine, psychophysiological, and other advanced methods. The serious neuropsychiatric disorders of childhood, such as autism, attention deficit disorder, and...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/8.2.205

    authors: Young JG,Cohen DJ,Shaywitz SE,Caparulo BK,Kavanagh ME,Hunt RD,Leckman JF,Anderson GM,Detlor J,Harcherik D,Shaywitz BA

    更新日期:1982-01-01 00:00:00

  • A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups.

    abstract::Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究

    doi:10.1093/schbul/sbv109

    authors: Gong Q,Dazzan P,Scarpazza C,Kasai K,Hu X,Marques TR,Iwashiro N,Huang X,Murray RM,Koike S,David AS,Yamasue H,Lui S,Mechelli A

    更新日期:2015-11-01 00:00:00

  • Morphological Profiling of Schizophrenia: Cluster Analysis of MRI-Based Cortical Thickness Data.

    abstract::The diagnosis of schizophrenia is thought to embrace several distinct subgroups. The manifold entities in a single clinical patient group increase the variance of biological measures, deflate the group-level estimates of causal factors, and mask the presence of treatment effects. However, reliable neurobiological boun...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbz112

    authors: Pan Y,Pu W,Chen X,Huang X,Cai Y,Tao H,Xue Z,Mackinley M,Limongi R,Liu Z,Palaniyappan L

    更新日期:2020-04-10 00:00:00

  • Genetic evidence for the existence of subgroups of the schizophrenic syndrome.

    abstract::Evidence for the existence of a genetic factor in the etiology of a significant proportion of the people diagnosed as having a schizophrenic disorder is reviewed. It is suggested that whatever is transmitted genetically need not be inherently pathologic and/or pathogenic. It is argued that only people who have certain...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/5.3.453

    authors: Cancro R

    更新日期:1979-01-01 00:00:00

  • Mobile assessment guide for research in schizophrenia and severe mental disorders.

    abstract::Mobile assessment techniques have been used for nearly 3 decades in mental health research, including in investigations of individuals with schizophrenia and other severe disorders. This article reviews the benefits of these data collection strategies relative to traditional self-report or clinician-administered measu...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbr186

    authors: Kimhy D,Myin-Germeys I,Palmier-Claus J,Swendsen J

    更新日期:2012-05-01 00:00:00

  • Effects of Endurance Training Combined With Cognitive Remediation on Everyday Functioning, Symptoms, and Cognition in Multiepisode Schizophrenia Patients.

    abstract::Aerobic exercise has been shown to improve symptoms in multiepisode schizophrenia, including cognitive impairments, but results are inconsistent. Therefore, we evaluated the effects of an enriched environment paradigm consisting of bicycle ergometer training and add-on computer-assisted cognitive remediation (CACR) tr...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbv020

    authors: Malchow B,Keller K,Hasan A,Dörfler S,Schneider-Axmann T,Hillmer-Vogel U,Honer WG,Schulze TG,Niklas A,Wobrock T,Schmitt A,Falkai P

    更新日期:2015-07-01 00:00:00

  • Increased critical stimulus duration: vulnerability or episode indicator?

    abstract::Increased critical stimulus duration among nonpsychotic subjects with Minnesota Multiphasic Personality Inventory 2-7-8 profiles in the Merritt and Balogh letter-discrimination procedure is consistent with the view that this abnormality might be a vulnerability indicator for a poor prognosis, chronic type of schizophr...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/11.3.344

    authors: Nuechterlein KH,Dawson ME

    更新日期:1985-01-01 00:00:00

  • Altered Thalamo-Cortical White Matter Connectivity: Probabilistic Tractography Study in Clinical-High Risk for Psychosis and First-Episode Psychosis.

    abstract::Disrupted thalamo-cortical connectivity is regarded as a core psychopathology in patients diagnosed with schizophrenia. However, whether the thalamo-cortical white matter connectivity is disrupted before the onset of psychosis is still unknown. To determine this gap in knowledge, the strength of thalamo-cortical white...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbv169

    authors: Cho KI,Shenton ME,Kubicki M,Jung WH,Lee TY,Yun JY,Kim SN,Kwon JS

    更新日期:2016-05-01 00:00:00

  • People with schizophrenia in five countries: conceptual similarities and intercultural differences in family caregiving.

    abstract::The European Psychiatric Services: Inputs Linked to Outcomes and Needs (EPSILON) study was a EU BIOMED-2-funded comparative, cross-national, cross-sectional study aimed (1) to produce standardized versions of five key research instruments in five languages, and (2) to compare the characteristics, needs, and life quali...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究

    doi:10.1093/oxfordjournals.schbul.a007029

    authors: van Wijngaarden B,Schene A,Koeter M,Becker T,Knapp M,Knudsen HC,Tansella M,Thornicroft G,Vázquez-Barquero JL,Lasalvia A,Leese M,EPSILON Study Group.

    更新日期:2003-01-01 00:00:00

  • Influence of emotional processing on working memory in schizophrenia.

    abstract::Research on emotional processing in schizophrenia suggests relatively intact subjective responses to affective stimuli "in the moment." However, neuroimaging evidence suggests diminished activation in brain regions associated with emotional processing in schizophrenia. We asked whether given a more vulnerable cognitiv...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbq009

    authors: Becerril K,Barch D

    更新日期:2011-09-01 00:00:00

  • The pharmacologic treatment of schizophrenia: a progress report.

    abstract::Pharmacologic agents currently used or being studied for the treatment of schizophrenia are reviewed. Neuroleptic medications are still the mainstay of treatment, but recent studies suggest new approaches to dosage and to the treatment of acute psychosis. Lithium is beneficial in psychotic illnesses with acute onset a...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/9.4.504

    authors: Donaldson SR,Gelenberg AJ,Baldessarini RJ

    更新日期:1983-01-01 00:00:00

  • Studies toward the subcortical pathogenesis of schizophrenia.

    abstract::In addition to introducing the six articles joined by our thematic outlook, this article addresses the importance of subcortical structures as they may be related to information processing and the life experience of schizophrenic patients. This is a heuristic exercise aimed at bridging the conceptual gaps between clin...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/13.4.555

    authors: Patterson T

    更新日期:1987-01-01 00:00:00

  • The effect of clozapine on premature mortality: an assessment of clinical monitoring and other potential confounders.

    abstract::Clozapine can cause severe adverse effects yet it is associated with reduced mortality risk. We test the hypothesis this association is due to increased clinical monitoring and investigate risk of premature mortality from natural causes. We identified 14 754 individuals (879 deaths) with serious mental illness (SMI) i...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbu120

    authors: Hayes RD,Downs J,Chang CK,Jackson RG,Shetty H,Broadbent M,Hotopf M,Stewart R

    更新日期:2015-05-01 00:00:00

  • The New York High-Risk Project: a followup report.

    abstract::The New York High-Risk Project began in 1971 as a prospective, longitudinal study of (1) children of one or two schizophrenic parents and (2) comparison groups of children whose parents had other or no psychiatric disorders. The former were examined because they were known to be at high risk--some 10-25 percent for ch...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/13.3.451

    authors: Erlenmeyer-Kimling L,Cornblatt B

    更新日期:1987-01-01 00:00:00

  • Adolescent Stress as a Driving Factor for Schizophrenia Development-A Basic Science Perspective.

    abstract::Schizophrenia has been associated with heightened stress responsivity in adolescence that precedes onset of psychosis. We now report that multiple stressors during adolescence in normal rats leads to deficits in adults analogous to that seen in schizophrenia patients. Moreover, impairment of stress control by lesion o...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbx033

    authors: Gomes FV,Grace AA

    更新日期:2017-05-01 00:00:00

  • Negative cognition, depressed mood, and paranoia: a longitudinal pathway analysis using structural equation modeling.

    abstract::The role of negative cognition and effect in maintaining psychotic symptoms is increasingly recognized but has yet to be substantiated though longitudinal analysis. Based on an a priori theoretical model, we hypothesized that negative cognition and depressed mood play a direct causal role in maintaining paranoia in pe...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbr019

    authors: Fowler D,Hodgekins J,Garety P,Freeman D,Kuipers E,Dunn G,Smith B,Bebbington PE

    更新日期:2012-09-01 00:00:00

  • Shared Genetic Risk of Schizophrenia and Gray Matter Reduction in 6p22.1.

    abstract::Genetic factors are known to influence both risk for schizophrenia (SZ) and variation in brain structure. A pressing question is whether the genetic underpinnings of brain phenotype and the disorder overlap. Using multivariate analytic methods and focusing on 1,402 common single-nucleotide polymorphisms (SNPs) mapped ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sby010

    authors: Chen J,Calhoun VD,Lin D,Perrone-Bizzozero NI,Bustillo JR,Pearlson GD,Potkin SG,van Erp TGM,Macciardi F,Ehrlich S,Ho BC,Sponheim SR,Wang L,Stephen JM,Mayer AR,Hanlon FM,Jung RE,Clementz BA,Keshavan MS,Gershon ES,Sw

    更新日期:2019-01-01 00:00:00

  • Psychological trauma and schizotypal symptoms.

    abstract::In a sample of 75 women recruited from the community, we measured trauma/maltreatment history and symptoms of schizotypal personality disorder, using both questionnaire and interview measures. As hypothesized, individuals with histories of trauma/maltreatment had elevated levels of schizotypal symptoms. Among types of...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a006985

    authors: Berenbaum H,Valera EM,Kerns JG

    更新日期:2003-01-01 00:00:00

  • Schizophrenic delusions: a phenomenological approach.

    abstract::The issue of specificity of delusions in schizophrenia is still a matter of debate. The authors analyze the delusion formation in schizophrenia from a prototypical, phenomenological point of view, focusing on the subject's experience. This perspective links delusion formation to the autistic predisposition, which is c...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/19.3.579

    authors: Bovet P,Parnas J

    更新日期:1993-01-01 00:00:00

  • Hallucinations in Children and Adolescents: An Updated Review and Practical Recommendations for Clinicians.

    abstract::Hallucinations in children and adolescents are now known to occur on a continuum from healthy to psychopathology-related phenomena. Although hallucinations in young populations are mostly transient, they can cause substantial distress. Despite hallucinations being widely investigated, research so far has had limited i...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sby119

    authors: Maijer K,Hayward M,Fernyhough C,Calkins ME,Debbané M,Jardri R,Kelleher I,Raballo A,Rammou A,Scott JG,Shinn AK,Steenhuis LA,Wolf DH,Bartels-Velthuis AA

    更新日期:2019-02-01 00:00:00