Abstract:
OBJECTIVE:Cross-sectional studies have shown associations between 22q11.2 deletion syndrome and schizophrenia. However, large-scale prospective studies have been lacking. We, therefore, conducted the first large-scale population based study on the risk of being diagnosed with schizophrenia in persons identified with 22q11.2 deletion syndrome. METHODS:Danish nationwide registers were linked to establish a cohort consisting of all Danish citizens born during 1955-2004 and the cohort was followed from January 1, 1994 until December 31, 2013. Data were analyzed using survival analyses and adjusted for calendar year, age, sex, and parental mental health history. RESULTS:A total of 156 individuals with 22q11.2 deletion syndrome were identified, out of which 6 individuals were diagnosed with schizophrenia spectrum disorders following identification with 22q11 deletion syndrome. Identified carriers of 22q11.2 deletion had an 8.13(95% CI: 3.65-18.09) fold increased risk of schizophrenia spectrum disorder. CONCLUSIONS:Carriers of a 22q11.2 deletion who had been clinically identified had a highly increased risk of schizophrenia spectrum disorders.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Vangkilde A,Olsen L,Hoeffding LK,Pedersen CB,Mortensen PB,Werge T,Trabjerg Bdoi
10.1093/schbul/sbv195subject
Has Abstractpub_date
2016-05-01 00:00:00pages
824-31issue
3eissn
0586-7614issn
1745-1701pii
sbv195journal_volume
42pub_type
杂志文章abstract::This study compared smoking behavior and motivation to quit smoking, assessed with a "stages of change" questionnaire, in outpatients with schizophrenia or schizoaffective disorder and in a representative sample of the general population. We conducted a mail survey in a representative sample of the general population ...
journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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pub_type: 评论,杂志文章
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journal_title:Schizophrenia bulletin
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,meta分析,评审
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更新日期:2007-09-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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journal_title:Schizophrenia bulletin
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a033421
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.schbul.a006903
更新日期:2001-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Schizophrenia bulletin
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Schizophrenia bulletin
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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