Visual context processing deficits in schizophrenia: effects of deafness and disorganization.

Abstract:

:Visual illusions allow for strong tests of perceptual functioning. Perceptual impairments can produce superior task performance on certain tasks (i.e., more veridical perception), thereby avoiding generalized deficit confounds while tapping mechanisms that are largely outside of conscious control. Using a task based on the Ebbinghaus illusion, a perceptual phenomenon where the perceived size of a central target object is affected by the size of surrounding inducers, we tested hypotheses related to visual integration in deaf (n = 31) and hearing (n = 34) patients with schizophrenia. In past studies, psychiatrically healthy samples displayed increased visual integration relative to schizophrenia samples and thus were less able to correctly judge target sizes. Deafness, and especially the use of sign language, leads to heightened sensitivity to peripheral visual cues and increased sensitivity to visual context. Therefore, relative to hearing subjects, deaf subjects were expected to display increased context sensitivity (ie, a more normal illusion effect as evidenced by a decreased ability to correctly judge central target sizes). Confirming the hypothesis, deaf signers were significantly more sensitive to the illusion than nonsigning hearing patients. Moreover, an earlier age of sign language acquisition, higher levels of linguistic ability, and shorter illness duration were significantly related to increased context sensitivity. As predicted, disorganization was associated with reduced context sensitivity for all subjects. The primary implications of these data are that perceptual organization impairment in schizophrenia is plastic and that it is related to a broader failure in coordinating cognitive activity.

journal_name

Schizophr Bull

journal_title

Schizophrenia bulletin

authors

Horton HK,Silverstein SM

doi

10.1093/schbul/sbr055

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

716-26

issue

4

eissn

0586-7614

issn

1745-1701

pii

sbr055

journal_volume

37

pub_type

杂志文章
  • Motivations that maintain substance use among individuals with psychotic disorders.

    abstract::This study quantitatively examined reasons for substance use among individuals with psychotic disorders and explored the relationship of these reasons to substance use problems and dependence. Sixty-nine people with psychotic disorders were interviewed using a battery of questionnaires called the Substance Use Scale f...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a006934

    authors: Spencer C,Castle D,Michie PT

    更新日期:2002-01-01 00:00:00

  • Going from social neuroscience to schizophrenia clinical trials.

    abstract::The goals of the project Social Cognition and Functioning in Schizophrenia (SCAF) were to (1) identify the domains to target from social neuroscience for translation to clinical schizophrenia research, (2) identify the paradigms that represent these domains for which the neural substrates are well documented, (3) adap...

    journal_title:Schizophrenia bulletin

    pub_type:

    doi:10.1093/schbul/sbt128

    authors: Green MF,Penn DL

    更新日期:2013-11-01 00:00:00

  • Abnormal EEG responses to photic stimulation in schizophrenic patients.

    abstract::Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. Drug-free schiz...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/16.4.627

    authors: Jin Y,Potkin SG,Rice D,Sramek J,Costa J,Isenhart R,Heh C,Sandman CA

    更新日期:1990-01-01 00:00:00

  • Elevated levels of schizotypal features in parents of patients with a family history of schizophrenia spectrum disorders.

    abstract::There is some evidence that schizotypal traits are related to a genetic or familial liability to develop schizophrenia. However, it is unclear whether the number of schizotypal traits is elevated in parents of schizophrenia patients compared with controls. This study used the Schizotypal Personality Questionnaire to i...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a007131

    authors: Appels MC,Sitskoorn MM,Vollema MG,Kahn RS

    更新日期:2004-01-01 00:00:00

  • Violent crime arrests and paranoid schizophrenia: the White House case studies.

    abstract::We have previously reported on typically paranoid schizophrenic patients who attempted to see the President or other prominent American political figures based on hallucinations or delusional beliefs. By obtaining arrest records on these White House Cases (WHCs), we were able to determine which individuals had murder ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/14.2.279

    authors: Shore D,Filson CR,Johnson WE

    更新日期:1988-01-01 00:00:00

  • What predicts a good response to cognitive remediation interventions?

    abstract::Cognitive remediation is a behavioral intervention designed to improve cognition in people who have suffered a decline in neuropsychological functioning. The application of cognitive remediation for people with schizophrenia has become increasingly popular. In this article we attempt to determine what factors moderate...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbi045

    authors: Medalia A,Richardson R

    更新日期:2005-10-01 00:00:00

  • Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation.

    abstract::Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects par...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbu115

    authors: Allen P,Chaddock CA,Egerton A,Howes OD,Barker G,Bonoldi I,Fusar-Poli P,Murray R,McGuire P

    更新日期:2015-03-01 00:00:00

  • A Meta-Analysis of Social Skills Training and Related Interventions for Psychosis.

    abstract:Objective:Evidence suggests that social skills training (SST) is an efficacious intervention for negative symptoms in psychosis, whereas evidence of efficacy in other psychosis symptom domains is limited. The current article reports a comprehensive meta-analytic review of the evidence for SST across relevant outcome me...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/schbul/sbx146

    authors: Turner DT,McGlanaghy E,Cuijpers P,van der Gaag M,Karyotaki E,MacBeth A

    更新日期:2018-04-06 00:00:00

  • Creating school-age versions of semistructured interviews for the prodrome to schizophrenia: lessons from case reviews.

    abstract::There is an increasing emphasis on identifying individuals with schizophrenia earlier and earlier in their disease process, with the assumption that earlier identification translates into earlier treatment, which translates into improved outcome. Unfortunately, one age cohort, children under 13 years of age, have been...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a007042

    authors: Ross RG,Schaeffer J,Compagnon N,Heinlein S,Beresford C,Farley G

    更新日期:2003-01-01 00:00:00

  • Psychotherapy with schizophrenics requires relevant training.

    abstract::Secondary sources continue to cite a one-page preliminary note about the Michigan State Psychotherapy Project, ignoring fuller reports in print. Relevant experience and training are critical to quality control of psychotherapy in schizophrenia research. This investigation is unique in that "experienced" meant that the...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/4.4.480

    authors: Karon BP

    更新日期:1978-01-01 00:00:00

  • The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?

    abstract::In follow-up from evidence obtained in linkage studies, systematic linkage disequilibrium mapping within chromosomal region 13q33 has led to the identification of a schizophrenia susceptibility locus which harbors the genes G72 and G30. These association findings have been replicated in several independent schizophren...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbl028

    authors: Abou Jamra R,Schmael C,Cichon S,Rietschel M,Schumacher J,Nöthen MM

    更新日期:2006-10-01 00:00:00

  • Cortical Volume Differences in Subjects at Risk for Psychosis Are Driven by Surface Area.

    abstract::In subjects at risk for psychosis, the studies on gray matter volume (GMV) predominantly reported volume loss compared with healthy controls (CON). However, other important morphological measurements such as cortical surface area (CSA) and cortical thickness (CT) were not systematically compared. So far, samples mostl...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbaa066

    authors: Buechler R,Wotruba D,Michels L,Theodoridou A,Metzler S,Walitza S,Hänggi J,Kollias S,Rössler W,Heekeren K

    更新日期:2020-12-01 00:00:00

  • Differentiating patterns of amygdala-frontal functional connectivity in schizophrenia and bipolar disorder.

    abstract:BACKGROUND:Insight into the neural mechanisms underlying the shared and disparate features of schizophrenia (SZ) and bipolar disorder (BD) is limited. The amygdala and prefrontal cortex (PFC) appear to have crucial roles in SZ and BD, yet abnormalities appear to manifest differently in the 2 disorders. METHODS:Eightee...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbt044

    authors: Liu H,Tang Y,Womer F,Fan G,Lu T,Driesen N,Ren L,Wang Y,He Y,Blumberg HP,Xu K,Wang F

    更新日期:2014-03-01 00:00:00

  • Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis: The OPTiMiSE Study.

    abstract::Individuals with psychoses have brain alterations, particularly in frontal and temporal cortices, that may be particularly prominent, already at illness onset, in those more likely to have poorer symptom remission following treatment with the first antipsychotic. The identification of strong neuroanatomical markers of...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbaa115

    authors: Dazzan P,Lawrence AJ,Reinders AATS,Egerton A,van Haren NEM,Merritt K,Barker GJ,Perez-Iglesias R,Sendt KV,Demjaha A,Nam KW,Sommer IE,Pantelis C,Wolfgang Fleischhacker W,van Rossum IW,Galderisi S,Mucci A,Drake R,Lewis S

    更新日期:2020-10-15 00:00:00

  • Toward a model of impaired reality testing in rats.

    abstract::Schizophrenia is a chronic brain disorder that affects about 1.1% of the adult US population annually. Hallucinations, delusions, and impaired reality testing are prominent symptoms of the disorder. Modeling these symptoms is difficult because it is unclear how to assess impaired reality testing in animals. Animals ca...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbp050

    authors: McDannald M,Schoenbaum G

    更新日期:2009-07-01 00:00:00

  • Chronic methamphetamine intoxication model of schizophrenia in animals.

    abstract::The chronic methamphetamine (MAP) intoxication model of schizophrenia in animals is outlined. The idea originated from the clinical and neurochemical similarities between MAP psychosis and schizophrenia that were found during the decade immediately after World War II when MAP abuse occurred in epidemic proportions in ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/18.1.107

    authors: Machiyama Y

    更新日期:1992-01-01 00:00:00

  • Altered brain long-range functional interactions underlying the link between aberrant self-experience and self-other relationship in first-episode schizophrenia.

    abstract::Self-experience anomalies are elementary features of schizophrenic pathology. Such deficits can have a profound impact on self-other relationship, but how they are related through aberrant brain function remains poorly understood. In this functional magnetic resonance imaging (fMRI) study, we provide new evidence for ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbt153

    authors: Ebisch SJ,Mantini D,Northoff G,Salone A,De Berardis D,Ferri F,Ferro FM,Di Giannantonio M,Romani GL,Gallese V

    更新日期:2014-09-01 00:00:00

  • Early brain wiring: activity-dependent processes.

    abstract::One of the leading theories of the neuropathology of schizophrenia is that it is a developmental disorder of "neural connectivity." To assess this theory, it is first necessary to understand how precise neural connections normally are established. Sensory-driven neural activity has been widely recognized as crucial fo...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/oxfordjournals.schbul.a006880

    authors: Penn AA

    更新日期:2001-01-01 00:00:00

  • A Randomized Controlled Trial of Group Coping-Oriented Therapy vs Supportive Therapy in Schizophrenia: Results of a 2-Year Follow-up.

    abstract:OBJECTIVE:Over the past 30 years, illness management programs and cognitive-behavioral therapy for psychosis have gained prominence in the treatment of schizophrenia. However, little is known about the long-term benefits of these types of programs when delivered during inpatient treatment following a symptom exacerbati...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/schbul/sbw032

    authors: Schaub A,Mueser KT,von Werder T,Engel R,Möller HJ,Falkai P

    更新日期:2016-07-01 00:00:00

  • Social networks and mental illness in a peasant society.

    abstract::Social networks of 35 mentally ill persons were studied in Lao villages. Mental illness was associated with a decrease in size of social networks, disproportionate reliance on family, and asymmetric instrumental exchange. Nonkin "sponsors" provided assistance to those alienated from or abandoned by relatives. For thos...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/7.1.125

    authors: Westermeyer J,Pattison EM

    更新日期:1981-01-01 00:00:00

  • Latent class analysis of DSM-IV schizotypal personality disorder criteria in psychiatric patients.

    abstract::The aim of the study was to evaluate the latent structure of DSM-IV schizotypal personality disorder (SPD) diagnostic criteria. The sample consisted of 564 consecutively admitted inpatients and outpatients. Exploratory latent class analysis identified a four-class model as the best fitting model for DSM-IV SPD criteri...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a006860

    authors: Fossati A,Maffei C,Battaglia M,Bagnato M,Donati D,Donini M,Fiorilli M,Novella L

    更新日期:2001-01-01 00:00:00

  • The cognitive basis of disorganization symptomatology in schizophrenia and its clinical correlates: toward a pathogenetic approach to disorganization.

    abstract::This article focuses on the schizophrenic disorganization syndrome, which was initially described by Bleuler (who used the term "dissociation") as lying at the heart of schizophrenia. While adopting a neo-Bleulerian approach, we describe schizophrenic disorganization using a pathogenetic hypothesis and a three-part st...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a007019

    authors: Hardy-Baylé MC,Sarfati Y,Passerieux C

    更新日期:2003-01-01 00:00:00

  • Psychophysiological dysfunctions in the developmental course of schizophrenic disorders.

    abstract::Psychophysiological anomalies in symptomatic schizophrenic patients, remitted schizophrenic patients, and individuals at heightened risk for a schizophrenic disorder are reviewed with an emphasis on electrodermal anomalies. Two electrodermal anomalies are identified in different subgroups of symptomatic patients: (1) ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/10.2.204

    authors: Dawson ME,Nuechterlein KH

    更新日期:1984-01-01 00:00:00

  • Symptomatic treatment of tardive dyskinesia: a word of caution.

    abstract::The search for a treatment of tardive dyskinesia (TD) has focused largely on cholinergic and GABAergic agents that are believed to attenuate striatal imbalances and bring about symptomatic control of dyskinetic movements. While numerous reports of the partial effectiveness of acute treatment with cholinergic or GABAer...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/7.4.571

    authors: Kucharski LT,Unterwald EM

    更新日期:1981-01-01 00:00:00

  • Brain Biomarkers of Vulnerability and Progression to Psychosis.

    abstract::Identifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions. This article presents a selective review of findings on risk prediction algorithms and potential mechanisms of onset in youth at clinical high-risk for ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbv173

    authors: Cannon TD

    更新日期:2016-07-01 00:00:00

  • What is schizophrenia?

    abstract::One of the main questions related to schizophrenia is, naturally enough, what is it? Such a question may seem obvious, naive, impossible, or any combination of these. And certainly it is a bit demanding to expect that anyone could say what schizophrenia is in 1,000 words. On the other hand, we felt that it was worth t...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/8.3.433

    authors: Meltzer HY,Liberman RP

    更新日期:1982-01-01 00:00:00

  • A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups.

    abstract::Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究

    doi:10.1093/schbul/sbv109

    authors: Gong Q,Dazzan P,Scarpazza C,Kasai K,Hu X,Marques TR,Iwashiro N,Huang X,Murray RM,Koike S,David AS,Yamasue H,Lui S,Mechelli A

    更新日期:2015-11-01 00:00:00

  • Antipsychotics: Past and Future: National Institute of Mental Health Division of Services and Intervention Research Workshop, July 14, 1998.

    abstract::A workshop on "Antipsychotics: Past and Future" was convened by the National Institute of Mental Health (NIMH), Division of Services and Intervention Research (DSIR), on July 14, 1998, to review the results of recent antipsychotic drug research, discuss current standards of treatment, and identify areas needing furthe...

    journal_title:Schizophrenia bulletin

    pub_type:

    doi:10.1093/oxfordjournals.schbul.a033387

    authors: Dawkins K,Lieberman JA,Lebowitz BD,Hsiao JK

    更新日期:1999-01-01 00:00:00

  • Sex differences in concordance rates for schizophrenia in twins.

    abstract::In response to my discussion of sex differences in concordance rates for schizophrenia in twins, Lewine (1979) noted that male schizophrenics are hospitalized earlier than females. He questioned whether females had been followed through the risk period. To clarify, I calculated the age at followup of discordant twins ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/5.1.8

    authors: Samuels L

    更新日期:1979-01-01 00:00:00

  • Vulnerability and schizoaffective psychosis: a two-factor model.

    abstract::Remitting illness such as affective or schizoaffective disorder is appropriately described by a vulnerability model. Clinical evidence is reviewed here to clarify the relationship between the affective-disorder-like and schizophrenia-like symptoms in a schizoaffective episode. A model is proposed which treats vulnerab...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/10.1.71

    authors: Braden W

    更新日期:1984-01-01 00:00:00