Creating school-age versions of semistructured interviews for the prodrome to schizophrenia: lessons from case reviews.

abstract：Objective:A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to the pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) and related comorbidities. We investigated the relative distribution of TNF-related molecules in blood and dorsolateral prefrontal cortex (DLPFC) in these...

journal_title：Schizophrenia bulletin

authors： Hoseth EZ,Ueland T,Dieset I,Birnbaum R,Shin JH,Kleinman JE,Hyde TM,Mørch RH,Hope S,Lekva T,Abraityte AJ,Michelsen AE,Melle I,Westlye LT,Ueland T,Djurovic S,Aukrust P,Weinberger DR,Andreassen OA

更新日期：2017-07-01 00:00:00

abstract：:Genetic variants conferring risk for schizophrenia (SCZ) have been extensively studied, but the role of posttranscriptional mechanisms in SCZ is not well studied. Here we performed the first genome-wide microRNA (miRNA) expression profiling in serum-derived exosome from 49 first-episode, drug-free SCZ patients and 46 ...

journal_title：Schizophrenia bulletin

authors： Du Y,Yu Y,Hu Y,Li XW,Wei ZX,Pan RY,Li XS,Zheng GE,Qin XY,Liu QS,Cheng Y

更新日期：2019-10-24 00:00:00

abstract：:This study compared the performance of 39 biological relatives of persons with schizophrenia to that of 30 normal adult controls on graphesthesia processing, a complex somatosensory processing task. The relatives performed significantly worse on the graphesthesia task compared to the healthy controls. The relatives an...

journal_title：Schizophrenia bulletin

authors： Chang BP,Lenzenweger MF

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in sc...

journal_title：Schizophrenia bulletin

authors： Shaikh M,Hall MH,Schulze K,Dutt A,Li K,Williams I,Walshe M,Constante M,Broome M,Picchioni M,Toulopoulou T,Collier D,Stahl D,Rijsdijk F,Powell J,Murray RM,Arranz M,Bramon E

更新日期：2013-01-01 00:00:00

abstract：:Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest fu...

journal_title：Schizophrenia bulletin

authors： Prasad KM,Keshavan MS

更新日期：2008-07-01 00:00:00

abstract：:Clozapine has been found to be superior to traditional neuroleptics in the treatment of refractory schizophrenia and is increasingly being used to treat schizophrenia, affective disorders, some neurological disorders, and aggression. For many patients, clozapine offers new hope for the successful pharmacological manag...

journal_title：Schizophrenia bulletin

authors： Young CR,Bowers MB Jr,Mazure CM

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Schizophrenia is associated with excess physical comorbidity. Yet, to our knowledge, large studies are lacking on the associations with somatic diseases before the onset of schizophrenia. The authors conducted a nationwide study of the full spectrum of treated somatic diseases before the first diagnosis of sc...

journal_title：Schizophrenia bulletin

authors： Sørensen HJ,Nielsen PR,Benros ME,Pedersen CB,Mortensen PB

更新日期：2015-03-01 00:00:00

abstract：:There is some evidence that schizotypal traits are related to a genetic or familial liability to develop schizophrenia. However, it is unclear whether the number of schizotypal traits is elevated in parents of schizophrenia patients compared with controls. This study used the Schizotypal Personality Questionnaire to i...

journal_title：Schizophrenia bulletin

authors： Appels MC,Sitskoorn MM,Vollema MG,Kahn RS

更新日期：2004-01-01 00:00:00

abstract：:Remitting illness such as affective or schizoaffective disorder is appropriately described by a vulnerability model. Clinical evidence is reviewed here to clarify the relationship between the affective-disorder-like and schizophrenia-like symptoms in a schizoaffective episode. A model is proposed which treats vulnerab...

journal_title：Schizophrenia bulletin

authors： Braden W

更新日期：1984-01-01 00:00:00

abstract：:Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...

journal_title：Schizophrenia bulletin

authors： Gong Q,Dazzan P,Scarpazza C,Kasai K,Hu X,Marques TR,Iwashiro N,Huang X,Murray RM,Koike S,David AS,Yamasue H,Lui S,Mechelli A

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Separable, but positively correlated, factors emerge from analyses of cognitive test data in schizophrenia and control samples (eg, verbal memory and processing speed) and these factors guide data reduction. Additionally, data support a hierarchical model of cognitive performance, in which these correlatio...

journal_title：Schizophrenia bulletin

authors： Dickinson D,Goldberg TE,Gold JM,Elvevåg B,Weinberger DR

更新日期：2011-11-01 00:00:00

abstract：:The article that follows is part of the Schizophrenia Bulletin's ongoing First Person Account series. We hope that mental health professionals--the Bulletin's primary audience--will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. In addition, we hope that...

journal_title：Schizophrenia bulletin

authors： Ribar AV

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Stressful life events have been implicated in the onset of psychotic disorders, but there are few robust studies. We sought to examine the nature and magnitude of associations between adult life events and difficulties and first-episode psychoses, particularly focusing on contextual characteristics, including...

journal_title：Schizophrenia bulletin

authors： Beards S,Fisher HL,Gayer-Anderson C,Hubbard K,Reininghaus U,Craig TJ,Di Forti M,Mondelli V,Pariante C,Dazzan P,Murray R,Morgan C

更新日期：2020-07-08 00:00:00

abstract：:In subjects at risk for psychosis, the studies on gray matter volume (GMV) predominantly reported volume loss compared with healthy controls (CON). However, other important morphological measurements such as cortical surface area (CSA) and cortical thickness (CT) were not systematically compared. So far, samples mostl...

journal_title：Schizophrenia bulletin

authors： Buechler R,Wotruba D,Michels L,Theodoridou A,Metzler S,Walitza S,Hänggi J,Kollias S,Rössler W,Heekeren K

更新日期：2020-12-01 00:00:00

abstract：:There is some support for the hypothesis that the factor structure of schizophrenia symptoms is similar to the factor structure of schizotypal symptoms in nonschizophrenia populations. However, no studies to date have examined schizotypal symptoms in patients with personality disorders. In this study, confirmatory fac...

journal_title：Schizophrenia bulletin

authors： Bergman AJ,Harvey PD,Mitropoulou V,Aronson A,Marder D,Silverman J,Trestman R,Siever LJ

更新日期：1996-01-01 00:00:00

abstract：:There is emerging evidence in schizophrenia of membrane abnormalities, primarily reductions in the essential omega-3 and omega-6 series of polyunsaturated fatty acids (PUFA). Because previous studies have largely been in chronic patients, it is not known whether these membrane abnormalities also occur early in illness...

journal_title：Schizophrenia bulletin

authors： Reddy RD,Keshavan MS,Yao JK

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Insight into the neural mechanisms underlying the shared and disparate features of schizophrenia (SZ) and bipolar disorder (BD) is limited. The amygdala and prefrontal cortex (PFC) appear to have crucial roles in SZ and BD, yet abnormalities appear to manifest differently in the 2 disorders. METHODS:Eightee...

journal_title：Schizophrenia bulletin

authors： Liu H,Tang Y,Womer F,Fan G,Lu T,Driesen N,Ren L,Wang Y,He Y,Blumberg HP,Xu K,Wang F

更新日期：2014-03-01 00:00:00

abstract：:Methodological issues involved in assessing the prevalence of substance abuse in schizophrenia are discussed, and previous research in this area is comprehensively reviewed. Many studies suffer from methodological shortcomings, including the lack of diagnostic rigor, adequate sample sizes, and simultaneous assessment ...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Yarnold PR,Levinson DF,Singh H,Bellack AS,Kee K,Morrison RL,Yadalam KG

更新日期：1990-01-01 00:00:00

abstract：:Comorbid major depressive disorder (MDD) in schizophrenia (SZ; SZ-MDD) has been identified as a major prognostic factor. However, the prevalence and associated factors of SZ-MDD have never been explored in a meta-analysis. All studies assessing the prevalence of SZ-MDD in stabilized outpatients with a standardized sca...

journal_title：Schizophrenia bulletin

authors： Etchecopar-Etchart D,Korchia T,Loundou A,Llorca PM,Auquier P,Lançon C,Boyer L,Fond G

更新日期：2020-11-30 00:00:00

abstract：:The evidence suggesting that genetic factors are involved in the etiology of schizophrenia is reviewed. Despite methodological and other difficulties, independent lines of research--family, twin, and adoption studies--point in a common direction: Persons genetically at risk for schizophrenia are more likely to become ...

journal_title：Schizophrenia bulletin

authors： Kessler S

更新日期：1980-01-01 00:00:00

abstract：:Approximately 100 years ago, a prominent German public figure name Daniel Schreber wrote memoirs of his experiences in asylums. His case was diagnosed Dementia Praecox at times and Paranoia at others by his treaters. Freud analyzed Schreber's memoirs from the perspective of his "libido" theory of developmentally organ...

journal_title：Schizophrenia bulletin

authors： McGlashan TH

更新日期：2009-05-01 00:00:00

abstract：:This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring between 1959 and 1967 to ...

journal_title：Schizophrenia bulletin

authors： Schaefer CA,Brown AS,Wyatt RJ,Kline J,Begg MD,Bresnahan MA,Susser ES

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Hippocampal abnormalities have been widely studied in schizophrenia spectrum populations including those at ultrahigh risk (UHR) for psychosis. There have been inconsistent findings concerning hippocampal morphology prior to and during the transition to psychosis, and little is known about how specific sub...

journal_title：Schizophrenia bulletin

authors： Dean DJ,Orr JM,Bernard JA,Gupta T,Pelletier-Baldelli A,Carol EE,Mittal VA

更新日期：2016-01-01 00:00:00

abstract：:We examined neurocognitive correlates of three dimensions of schizotypy in 63 healthy first degree relatives of schizophrenia patients. Neurocognitive measures of attention, verbal memory, and prefrontal functioning were combined with self-report and interview measures of schizotypy. State-psychopathology (anxiety and...

journal_title：Schizophrenia bulletin

authors： Vollema MG,Postma B

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fract...

journal_title：Schizophrenia bulletin

authors： Peters BD,Szeszko PR,Radua J,Ikuta T,Gruner P,DeRosse P,Zhang JP,Giorgio A,Qiu D,Tapert SF,Brauer J,Asato MR,Khong PL,James AC,Gallego JA,Malhotra AK

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Executive control of attention in schizophrenia has recently been assessed by means of the Attention Network Test (ANT). In the past, for tasks assessing executive attention, findings in schizophrenia have been contradictory, among others suggesting a lack of increased stimulus interference effects. Attentio...

journal_title：Schizophrenia bulletin

authors： Opgen-Rhein C,Neuhaus AH,Urbanek C,Hahn E,Sander T,Dettling M

更新日期：2008-11-01 00:00:00

abstract：:Schizotypal disorder is characterized by odd behavior and attenuated forms of schizophrenic features without the manifestation of overt and sustained psychoses. Past studies suggest that schizotypal disorder shares biological and psychological commonalties with schizophrenia. Structural magnetic resonance imaging (MRI...

journal_title：Schizophrenia bulletin

authors： Takayanagi Y,Sasabayashi D,Takahashi T,Furuichi A,Kido M,Nishikawa Y,Nakamura M,Noguchi K,Suzuki M

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:Adolescence can be a challenging time, characterized by self-consciousness, heightened regard for peer acceptance, and fear of rejection. Interpersonal concerns are amplified by unpredictable social interactions, both online and offline. This developmental and social context is potentially conducive to the e...

journal_title：Schizophrenia bulletin

authors： Bird JC,Evans R,Waite F,Loe BS,Freeman D

更新日期：2019-09-11 00:00:00

abstract：:The role of negative cognition and effect in maintaining psychotic symptoms is increasingly recognized but has yet to be substantiated though longitudinal analysis. Based on an a priori theoretical model, we hypothesized that negative cognition and depressed mood play a direct causal role in maintaining paranoia in pe...

journal_title：Schizophrenia bulletin

authors： Fowler D,Hodgekins J,Garety P,Freeman D,Kuipers E,Dunn G,Smith B,Bebbington PE

更新日期：2012-09-01 00:00:00

abstract：:In 1917, Eugen Bleuler published an article (Mendelismus bei Psychosen, speziell bei der Schizophrenie [Mendelism in the Psychoses, especially Schizophrenia]) in response to the recently published first systematic family study of dementia praecox (DP) by Ernst Rüdin, then working under Kraepelin in Munich. Although br...

journal_title：Schizophrenia bulletin

authors： Kendler KS

更新日期：2020-07-08 00:00:00