Abstract：
BACKGROUND:In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fractional anisotropy (FA), a putative measure of WM integrity, from childhood into adolescence. However, the WM tracts that show FA increases have been variable across studies. Here, we aimed to assess which WM tracts show the most pronounced changes across adolescence. METHODS:DTI was performed in 78 healthy subjects aged 8-21 years, and voxel-wise analysis conducted using tract-based spatial statistics (TBSS). In addition, we performed the first meta-analysis of TBSS studies on WM development in adolescence. RESULTS:In our sample, we observed bilateral increases in FA with age, which were most significant in the left superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and anterior thalamic radiation. These findings were confirmed by the meta-analysis, and FA increase in the bilateral SLF was the most consistent finding across studies. Moreover, in our sample, FA of the bilateral SLF showed a positive association with verbal working memory performance and partially mediated increases in verbal fluency as a function of increasing age. CONCLUSIONS:These data highlight increasing connectivity in the SLF during adolescence. In light of evidence for compromised SLF integrity in high-risk and first-episode patients, these data suggest that abnormal maturation of the SLF during adolescence may be a key target in the neurodevelopment of schizophrenia.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Peters BD,Szeszko PR,Radua J,Ikuta T,Gruner P,DeRosse P,Zhang JP,Giorgio A,Qiu D,Tapert SF,Brauer J,Asato MR,Khong PL,James AC,Gallego JA,Malhotra AKdoi
10.1093/schbul/sbs054subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1308-17issue
6eissn
0586-7614issn
1745-1701pii
sbs054journal_volume
38pub_type
杂志文章,meta分析abstract：:Approximately 100 years ago, a prominent German public figure name Daniel Schreber wrote memoirs of his experiences in asylums. His case was diagnosed Dementia Praecox at times and Paranoia at others by his treaters. Freud analyzed Schreber's memoirs from the perspective of his "libido" theory of developmentally organ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbp019
更新日期：2009-05-01 00:00:00
abstract：:Impaired attention is commonly observed among schizophrenia patients and those at genetic risk for the disease. This article reviews over 40 studies that used various versions of the Continuous Performance Test (CPT) as the primary measure of attention. These studies of normal subjects, affected patients, and various ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/20.1.31
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:The homicide of strangers by people with psychosis, referred to here as "stranger homicides," are rare and tragic events that generate adverse publicity for mental health services and have resulted in significant changes in mental health policy and law. AIM:To estimate the incidence of stranger homicides, u...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,meta分析
doi：10.1093/schbul/sbp112
更新日期：2011-05-01 00:00:00
abstract：:Distinguishing between brain-damaged and schizophrenic patients remains a significant clinical problem. However, substantive and methodological difficulties have led to discouragement and consequent loss of interest in this area of differential diagnosis. Several models for making this distinction were proposed: cogni...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/4.2.160
更新日期：1978-01-01 00:00:00
abstract：:Recent studies provide considerable evidence that schizophrenia and bipolar disorder may share overlapping etiologic determinants. Identifying disease-related genetic effects is a major focus in schizophrenia and bipolar disorder research, with implications for clarifying diagnosis and developing specific treatments f...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbn055
更新日期：2008-07-01 00:00:00
abstract：:A pilot study of the effects of metacognition-oriented social skills training (MOSST) on social functioning in patients with schizophrenia spectrum disorders (SSDs) reported promising results. The main purpose of the current trial was to compare the effectiveness and potential benefits of MOSST vs conventional social ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,随机对照试验
doi：10.1093/schbul/sbx168
更新日期：2018-10-17 00:00:00
abstract：:Persons with schizophrenia have a reduced life expectancy largely due to death from natural causes. Factors that have been previously associated with excess mortality include cigarette smoking and antipsychotic medication. The role of other environmental factors such as exposure to infectious agents has been the subje...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbt113
更新日期：2014-07-01 00:00:00
abstract：:Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, are common for patients with schizophrenia and might also be present in individuals ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sby139
更新日期：2019-06-18 00:00:00
abstract：:An important development in cognitive remediation of schizophrenia is a focus on motivation. However, following a distinction between the concepts of intrinsic motivation (IM) and extrinsic motivation, discussions of IM-based methods have downplayed or misrepresented the role that extrinsic rewards can, and actually d...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbp160
更新日期：2010-09-01 00:00:00
abstract：:A series of human and animal investigations has suggested that altered expression and function of the alpha7-nicotinic cholinergic receptor may be responsible for the auditory sensory gating deficit characterized in schizophrenia patients and their relatives as diminished suppression of an auditory-evoked response (P5...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/oxfordjournals.schbul.a033320
更新日期：1998-01-01 00:00:00
abstract：:In follow-up from evidence obtained in linkage studies, systematic linkage disequilibrium mapping within chromosomal region 13q33 has led to the identification of a schizophrenia susceptibility locus which harbors the genes G72 and G30. These association findings have been replicated in several independent schizophren...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/sbl028
更新日期：2006-10-01 00:00:00
abstract：:As part of a long-term study in schizophrenia, a model of family intervention has been developed which attempts to diminish relapse rates of schizophrenic patients. This model reflects theoretical and research findings which suggest that certain patients have a "core psychological deficit" that might increase vulnerab...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/6.3.490
更新日期：1980-01-01 00:00:00
abstract：:The author reviews a number of studies which have shown that the overall mortality among patients with schizophrenia is about twice that in the general population. The highest excess mortality is found in suicide and violent death, but there seems to be an increased mortality also in cardiovascular disorders. Whether ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/15.1.81
更新日期：1989-01-01 00:00:00
abstract：:As a result of improving technologies and greatly increased sample sizes, the last 2 years has seen unprecedented advances in identification of specific genetic risk factors for psychiatric phenotypes. Strong genetic associations have been reported at common polymorphisms within ANK3 and CACNA1C in bipolar disorder an...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbp020
更新日期：2009-05-01 00:00:00
abstract：:Family studies of schizophrenia frequently include relatives of schizophrenia probands with diagnoses falling within the schizophrenia spectrum. As part of an ongoing genetic linkage study of schizophrenia, the authors examined case material from 50 relatives (of schizophrenia probands) who received a DSM-III-R diagno...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/20.4.747
更新日期：1994-01-01 00:00:00
abstract：:Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbx150
更新日期：2018-06-06 00:00:00
abstract：:Abnormalities in both time processing and dopamine (DA) neurotransmission have been observed in schizophrenia. Time processing seems to be linked to DA neurotransmission. The cognitive dysmetria hypothesis postulates that psychosis might be a manifestation of the loss of coordination of mental processes due to impaire...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbw065
更新日期：2016-11-01 00:00:00
abstract：:Self-experience anomalies are elementary features of schizophrenic pathology. Such deficits can have a profound impact on self-other relationship, but how they are related through aberrant brain function remains poorly understood. In this functional magnetic resonance imaging (fMRI) study, we provide new evidence for ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbt153
更新日期：2014-09-01 00:00:00
abstract：:This study investigated the role of reasoning biases in delusion formation and maintenance. Reasoning judgments have been shown to be influenced by prior knowledge, beliefs, and experience--that is, information stored in semantic memory. It was hypothesized that high schizotypes would exhibit a "jump to conclusions" s...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbi012
更新日期：2005-01-01 00:00:00
abstract：:The purpose of this study was to assess how neurocognition and social cognition were associated with initial functional level and with rates of functional change in intensive community-based psychosocial rehabilitation interventions that have been shown to yield significant functional change for individuals diagnosed ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,多中心研究
doi：10.1093/schbul/sbl072
更新日期：2007-09-01 00:00:00
abstract：:North American outcome studies of schizophrenia conducted within the past quarter century are reviewed if their minimum average followup is 10 years and they meet at least some modern design criteria. Ten such investigations are described and summarized. Taken as a whole, they demonstrate that schizophrenia can be a c...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/14.4.515
更新日期：1988-01-01 00:00:00
abstract：:The prodrome of psychosis has become a target for early identification and for treatments that address both symptoms and risk for future psychosis. Interest and activity in this realm is now worldwide. Clinical trials with rigorous methodology have only just begun, making treatment guidelines premature. Despite the sp...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,多中心研究
doi：10.1093/schbul/sbm025
更新日期：2007-05-01 00:00:00
abstract：:We have previously reported on typically paranoid schizophrenic patients who attempted to see the President or other prominent American political figures based on hallucinations or delusional beliefs. By obtaining arrest records on these White House Cases (WHCs), we were able to determine which individuals had murder ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/14.2.279
更新日期：1988-01-01 00:00:00
abstract：:Evidence from psychophysiological and behavioral investigations of lateralization in psychosis separates two clinical syndromes. A speculative model is offered in which the syndromes approximate the clinical features of paranoid compared with nonparanoid patients in investigations in which the groups have been disting...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/7.4.662
更新日期：1981-01-01 00:00:00
abstract：:A number of psychosocial treatments are available for persons with schizophrenia that include social skills training, cognitive behavioral therapy, cognitive remediation, and social cognition training. These treatments are reviewed and discussed in terms of how they address key components of functional recovery such a...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/sbn177
更新日期：2009-03-01 00:00:00
abstract：:Methodological issues involved in assessing the prevalence of substance abuse in schizophrenia are discussed, and previous research in this area is comprehensively reviewed. Many studies suffer from methodological shortcomings, including the lack of diagnostic rigor, adequate sample sizes, and simultaneous assessment ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/16.1.31
更新日期：1990-01-01 00:00:00
abstract：:This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/19.4.831
更新日期：1993-01-01 00:00:00
abstract：:The purpose of this study was (1) to identify the demographic and psychosocial characteristics of Korean-Americans with schizophrenia, and (2) to compare the demographic and psychosocial characteristics of Korean-Americans with schizophrenia to African-American, Latino, and Euro-American individuals with schizophrenia...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/oxfordjournals.schbul.a006974
更新日期：2002-01-01 00:00:00
abstract：:Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. Drug-free schiz...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/16.4.627
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVE:Cannabis use is associated with a younger age at onset of psychosis, an indicator of poor prognosis, but better cognitive function, a positive prognostic indicator. We aimed to clarify the role of age at onset and cognition on outcomes in cannabis users with first-episode schizophrenia as well as the effect o...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbq153
更新日期：2012-06-01 00:00:00
