Neurocognitive correlates of schizotypy in first degree relatives of schizophrenia patients.

abstract：:The two indices that have been proposed for quantifying the accuracy of smooth-following eye movements are shown to be interchangeable. This algebraic fact will permit comparability of values between laboratories only if workers who employ the signal-to-noise ratio (S/N) as their index measure S and N as the total sig...

journal_title：Schizophrenia bulletin

authors： Lykken DT,Iacono WG,Lykken JD

更新日期：1981-01-01 00:00:00

abstract：:People with serious mental illness (SMI) have mortality rates 2 to 3 times higher than the overall US population, largely due to cardiovascular disease. The prevalence of cardiovascular risk factors such as obesity and diabetes mellitus and other conditions, such as HIV/AIDS, is heightened in this group. Based on the ...

journal_title：Schizophrenia bulletin

authors： McGinty EE,Baller J,Azrin ST,Juliano-Bult D,Daumit GL

更新日期：2016-01-01 00:00:00

abstract：:In subjects at risk for psychosis, the studies on gray matter volume (GMV) predominantly reported volume loss compared with healthy controls (CON). However, other important morphological measurements such as cortical surface area (CSA) and cortical thickness (CT) were not systematically compared. So far, samples mostl...

journal_title：Schizophrenia bulletin

authors： Buechler R,Wotruba D,Michels L,Theodoridou A,Metzler S,Walitza S,Hänggi J,Kollias S,Rössler W,Heekeren K

更新日期：2020-12-01 00:00:00

abstract：:Psychiatric research, including the search for predisposing genes, has tended to proceed under the assumptions that schizophrenia and bipolar disorder, as defined in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and International Statistical Classification of Diseases, 10th Revision, are discr...

journal_title：Schizophrenia bulletin

authors： Owen MJ,Craddock N,Jablensky A

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Patients with deficit schizophrenia differ from nondeficit patients with schizophrenia relative to several neurobiological correlates and relative to the risk factors of family history and season of birth. Exposure to human herpesviruses is a possible risk factor for schizophrenia. We hypothesized that there...

journal_title：Schizophrenia bulletin

authors： Dickerson F,Kirkpatrick B,Boronow J,Stallings C,Origoni A,Yolken R

更新日期：2006-04-01 00:00:00

abstract：:Cognitive deficits are a central and debilitating aspect of schizophrenia and other major mental illnesses. Although they are largely refractory to pharmacotherapy, multiple studies have now shown that large and lasting improvements in cognition can result from behavioral interventions. We will review our work over th...

journal_title：Schizophrenia bulletin

authors： Wexler BE,Bell MD

更新日期：2005-10-01 00:00:00

abstract：:The question of whether schizophrenia is associated with structural or functional abnormalities of the nervous system, or both, has become the principal focus of biological studies of schizophrenia. Computed tomography studies have revealed ventricular enlargement and cortical atrophy in a subgroup of schizophrenic pa...

journal_title：Schizophrenia bulletin

authors： Meltzer HY

更新日期：1987-01-01 00:00:00

abstract：:Many previous observers have reported some qualitative similarities between the normal mental state of dreaming and the abnormal mental state of psychosis. Recent psychological, tomographic, electrophysiological, and neurochemical data appear to confirm the functional similarities between these 2 states. In this study...

journal_title：Schizophrenia bulletin

authors： Scarone S,Manzone ML,Gambini O,Kantzas I,Limosani I,D'Agostino A,Hobson JA

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in sc...

journal_title：Schizophrenia bulletin

authors： Shaikh M,Hall MH,Schulze K,Dutt A,Li K,Williams I,Walshe M,Constante M,Broome M,Picchioni M,Toulopoulou T,Collier D,Stahl D,Rijsdijk F,Powell J,Murray RM,Arranz M,Bramon E

更新日期：2013-01-01 00:00:00

abstract：:In 1917, Eugen Bleuler published an article (Mendelismus bei Psychosen, speziell bei der Schizophrenie [Mendelism in the Psychoses, especially Schizophrenia]) in response to the recently published first systematic family study of dementia praecox (DP) by Ernst Rüdin, then working under Kraepelin in Munich. Although br...

journal_title：Schizophrenia bulletin

authors： Kendler KS

更新日期：2020-07-08 00:00:00

abstract：:Delusions, the fixed false beliefs characteristic of psychotic illness, have long defied understanding despite their response to pharmacological treatments (e.g., D2 receptor antagonists). However, it can be challenging to discern what makes beliefs delusional compared with other unusual or erroneous beliefs. We sugge...

journal_title：Schizophrenia bulletin

authors： Feeney EJ,Groman SM,Taylor JR,Corlett PR

更新日期：2017-03-01 00:00:00

abstract：:Schizophrenia is but one form of psychosis; therefore, it is important to control for the psychotic factor in studies of the schizophrenic syndrome. A survey was done of 478 articles in 15 major psychiatric and psychological journals to determine the frequency of controls for psychosis in schizophrenia research. The s...

journal_title：Schizophrenia bulletin

authors： Ritzler BA,Rinehart K

更新日期：1981-01-01 00:00:00

abstract：:Patients with schizophrenia are often characterized as lacking insight or awareness into their illness and symptoms, yet despite considerable research, we still lack a full understanding of the factors involved in causing poor awareness. Within schizophrenia, there has been shown to be a fractionation across dimension...

journal_title：Schizophrenia bulletin

authors： Gilleen J,Greenwood K,David AS

更新日期：2011-01-01 00:00:00

abstract：:Clozapine can cause severe adverse effects yet it is associated with reduced mortality risk. We test the hypothesis this association is due to increased clinical monitoring and investigate risk of premature mortality from natural causes. We identified 14 754 individuals (879 deaths) with serious mental illness (SMI) i...

journal_title：Schizophrenia bulletin

authors： Hayes RD,Downs J,Chang CK,Jackson RG,Shetty H,Broadbent M,Hotopf M,Stewart R

更新日期：2015-05-01 00:00:00

abstract：:The search for a treatment of tardive dyskinesia (TD) has focused largely on cholinergic and GABAergic agents that are believed to attenuate striatal imbalances and bring about symptomatic control of dyskinetic movements. While numerous reports of the partial effectiveness of acute treatment with cholinergic or GABAer...

journal_title：Schizophrenia bulletin

authors： Kucharski LT,Unterwald EM

更新日期：1981-01-01 00:00:00

abstract：:We reported previously that residents of Greater Helsinki, Finland, whose mothers were exposed to the 1957 influenza epidemic during their second trimester of gestation had a significantly elevated risk of developing adult schizophrenia. The majority of the replication studies to date have not determined whether the m...

journal_title：Schizophrenia bulletin

authors： Mednick SA,Huttunen MO,Machón RA

更新日期：1994-01-01 00:00:00

abstract：:This study tested hypothesized relationships between neuropsychological and psychophysiological variables and concurrent levels of clinical and psychosocial functioning in schizophrenia. The sample consisted of 40 subjects diagnosed with a chronic schizophrenia spectrum disorder and living in community-based settings....

journal_title：Schizophrenia bulletin

authors： Brekke JS,Raine A,Ansel M,Lencz T,Bird L

更新日期：1997-01-01 00:00:00

abstract：:The dopamine hypothesis of schizophrenia is usually presented in a static, rather than dynamic fashion. We propose that increased dopaminergic activity may represent a stage of a dynamic schizophrenic process rather than its cause. Dopamine, as well as other neurotransmitters, responds in an adaptive fashion to stimul...

journal_title：Schizophrenia bulletin

authors： Csernansky JG,Holman CA,Hollister LE

更新日期：1983-01-01 00:00:00

abstract：:The Seventh International Congress on Schizophrenia Research was held in Santa Fe, New Mexico, in April 1999. This was the largest Congress meeting to date, with almost 1,000 presentations that covered all aspects of schizophrenia research. This article provides an account of the Congress proceedings. Several research...

journal_title：Schizophrenia bulletin

authors： Buckley PF,Buchanan RW,Tamminga CA,Schulz SC

更新日期：2000-01-01 00:00:00

abstract：:One neuropathological feature of schizophrenia is a diminished number of dendritic spines in the prefrontal cortex and hippocampus. The neuregulin 1 (Nrg1) system is involved in the plasticity of dendritic spines, and chronic stress decreases dendritic spine densities in the prefrontal cortex and hippocampus. Here, we...

journal_title：Schizophrenia bulletin

authors： Clarke DJ,Chohan TW,Kassem MS,Smith KL,Chesworth R,Karl T,Kuligowski MP,Fok SY,Bennett MR,Arnold JC

更新日期：2019-03-07 00:00:00

abstract：:The present functional magnetic resonance imaging study investigated the neural correlates of practice-associated activation changes in patients with schizophrenia and their association with symptom severity. A group of patients (n = 24) were divided into more successful and less successful learners and were asked to ...

journal_title：Schizophrenia bulletin

authors： Koch K,Wagner G,Schachtzabel C,Schultz C,Sauer H,Schlösser RG

更新日期：2010-05-01 00:00:00

abstract：:The goals of the project Social Cognition and Functioning in Schizophrenia (SCAF) were to (1) identify the domains to target from social neuroscience for translation to clinical schizophrenia research, (2) identify the paradigms that represent these domains for which the neural substrates are well documented, (3) adap...

journal_title：Schizophrenia bulletin

authors： Green MF,Penn DL

更新日期：2013-11-01 00:00:00

abstract：:A major factor associated with poor prognostic outcome after a first psychotic break is cannabis misuse, which is prevalent in schizophrenia and particularly common in individuals with recent-onset psychosis. Behavioral interventions aimed at reducing cannabis use have been unsuccessful in this population. Cannabidiol...

journal_title：Schizophrenia bulletin

authors： Hahn B

更新日期：2018-01-13 00:00:00

abstract：:Disruption of sleep/wake cycles is common in patients with schizophrenia and correlates with cognitive and affective abnormalities. Mice deficient in stable tubule only polypeptide (STOP) show cognitive, behavioral, and neurobiological deficits that resemble those seen in patients with schizophrenia, but little is kno...

journal_title：Schizophrenia bulletin

authors： Profitt MF,Deurveilher S,Robertson GS,Rusak B,Semba K

更新日期：2016-09-01 00:00:00

abstract：:We studied schizophrenia spectrum disorders in Chernobyl accident survivors by analyzing Chernobyl exclusion zone (EZ) archives (1986-1997) and by conducting a psychophysiological examination of 100 patients with acute radiation sickness (ARS) and 100 workers of the Chernobyl EZ who had worked as "liquidators-voluntee...

journal_title：Schizophrenia bulletin

authors： Loganovsky KN,Loganovskaja TK

更新日期：2000-01-01 00:00:00

abstract：:It is increasingly evident that the brain is not truly an immune privileged site and that cells of the central nervous system are sensitive to the inflammation generated when the brain is fighting off infection. Among the many microorganisms that have access to the brain, the apicomplexan protozoan Toxoplasma gondii h...

journal_title：Schizophrenia bulletin

authors： Xiao J,Prandovszky E,Kannan G,Pletnikov MV,Dickerson F,Severance EG,Yolken RH

更新日期：2018-08-20 00:00:00

abstract：OBJECTIVE:Over the past 30 years, illness management programs and cognitive-behavioral therapy for psychosis have gained prominence in the treatment of schizophrenia. However, little is known about the long-term benefits of these types of programs when delivered during inpatient treatment following a symptom exacerbati...

journal_title：Schizophrenia bulletin

authors： Schaub A,Mueser KT,von Werder T,Engel R,Möller HJ,Falkai P

更新日期：2016-07-01 00:00:00

abstract：:Although the various manifestations of disordered thought have played a central role in diagnostic and theoretical considerations of schizophrenia, such symptoms have not been found specific to schizophrenia, and at best have shown weak relations to outcome. As part of a 7-year followup study of a sample of young, acu...

journal_title：Schizophrenia bulletin

authors： Knight RA,Elliott DS,Roff JD,Watson CG

更新日期：1986-01-01 00:00:00

abstract：:Every year numerous reports on antipsychotic drug trials are being published in neuropsychiatric journals, adding new information to our knowledge in the field. The information however is often hard for the reader to interpret, sometimes contradictory to comparable available studies and leaves more questions open than...

journal_title：Schizophrenia bulletin

authors： Leucht S,Heres S,Hamann J,Kane JM

更新日期：2008-03-01 00:00:00

abstract：:Recent advances in functional genomics have facilitated the identification of multiple genes and isoforms associated with the genetic risk of schizophrenia, yet the causal variations remain largely unclear. A previous study reported that the schizophrenia risk single-nucleotide polymorphism (SNP) rs7085104 at 10q24.32...

journal_title：Schizophrenia bulletin

authors： Cai X,Yang ZH,Li HJ,Xiao X,Li M,Chang H

更新日期：2021-01-23 00:00:00