Updated schizophrenia PORT treatment recommendations: a commentary.

abstract：:Individuals with psychoses have brain alterations, particularly in frontal and temporal cortices, that may be particularly prominent, already at illness onset, in those more likely to have poorer symptom remission following treatment with the first antipsychotic. The identification of strong neuroanatomical markers of...

journal_title：Schizophrenia bulletin

authors： Dazzan P,Lawrence AJ,Reinders AATS,Egerton A,van Haren NEM,Merritt K,Barker GJ,Perez-Iglesias R,Sendt KV,Demjaha A,Nam KW,Sommer IE,Pantelis C,Wolfgang Fleischhacker W,van Rossum IW,Galderisi S,Mucci A,Drake R,Lewis S

更新日期：2020-10-15 00:00:00

abstract：:The design of the Positive and Negative Syndrome Scale (PANSS) with item levels ranging from 1 to 7 leads to the trivial result that the 30-item scale's zero level (no symptoms) is 30. This causes serious problems when ratios are calculated which always implicitly depend on a natural zero point (equals 0). Recent publ...

journal_title：Schizophrenia bulletin

authors： Obermeier M,Mayr A,Schennach-Wolff R,Seemüller F,Möller HJ,Riedel M

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. METHODS:I...

journal_title：Schizophrenia bulletin

authors： Lavigne KM,Rapin LA,Metzak PD,Whitman JC,Jung K,Dohen M,Lœvenbruck H,Woodward TS

更新日期：2015-01-01 00:00:00

abstract：:We examined neurocognitive correlates of three dimensions of schizotypy in 63 healthy first degree relatives of schizophrenia patients. Neurocognitive measures of attention, verbal memory, and prefrontal functioning were combined with self-report and interview measures of schizotypy. State-psychopathology (anxiety and...

journal_title：Schizophrenia bulletin

authors： Vollema MG,Postma B

更新日期：2002-01-01 00:00:00

abstract：:Staff members from nine mental health agencies were trained in psychiatric rehabilitation technology. The trainers then received intensive followup to assist them in implementing the technology in their own agencies. Evaluation of the impact of the "training of trainers" strategy suggested that mental health workers w...

journal_title：Schizophrenia bulletin

authors： Rogers ES,Cohen BF,Danley KS,Hutchinson D,Anthony WA

更新日期：1986-01-01 00:00:00

abstract：:The New York High-Risk Project began in 1971 as a prospective, longitudinal study of (1) children of one or two schizophrenic parents and (2) comparison groups of children whose parents had other or no psychiatric disorders. The former were examined because they were known to be at high risk--some 10-25 percent for ch...

journal_title：Schizophrenia bulletin

authors： Erlenmeyer-Kimling L,Cornblatt B

更新日期：1987-01-01 00:00:00

abstract：:Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-related weight gain is missing. In this review, random effects meta-analyses were conducted for dominant and recessive models on association...

journal_title：Schizophrenia bulletin

authors： Zhang JP,Lencz T,Zhang RX,Nitta M,Maayan L,John M,Robinson DG,Fleischhacker WW,Kahn RS,Ophoff RA,Kane JM,Malhotra AK,Correll CU

更新日期：2016-11-01 00:00:00

abstract：:In a previous article in the Schizophrenia Bulletin (Vol. 22, No. 1, 1996), we presented findings of a study on the clinical and rehabilitative effects of work activity on 150 subjects diagnosed with schizophrenia or schizoaffective disorder. Subjects were randomly assigned to either a Pay ($3.40/hr) or No-Pay group a...

journal_title：Schizophrenia bulletin

authors： Bell MD,Lysaker PH

更新日期：1997-01-01 00:00:00

abstract：:A substantial proportion of patients with schizophrenia experience the onset of their illness by age 18. Data from phenomenological, cognitive, neuroimaging, and genetic studies suggest a similar profile of clinical and neurobiological abnormalities between early- and adult-onset patients. However, children and adoles...

journal_title：Schizophrenia bulletin

authors： Kumra S,Charles Schulz S

更新日期：2008-01-01 00:00:00

abstract：:In 1917, Eugen Bleuler published an article (Mendelismus bei Psychosen, speziell bei der Schizophrenie [Mendelism in the Psychoses, especially Schizophrenia]) in response to the recently published first systematic family study of dementia praecox (DP) by Ernst Rüdin, then working under Kraepelin in Munich. Although br...

journal_title：Schizophrenia bulletin

authors： Kendler KS

更新日期：2020-07-08 00:00:00

abstract：Background:The diagnostic and prognostic significance of the DSM-5-defined Attenuated Psychosis Syndrome (DSM-5-APS) in individuals undergoing an ultra high risk (UHR) clinical assessment for suspicion of psychosis risk is unknown. Methods:Prospective cohort study including all consecutive help-seeking individuals und...

journal_title：Schizophrenia bulletin

authors： Fusar-Poli P,De Micheli A,Cappucciati M,Rutigliano G,Davies C,Ramella-Cravaro V,Oliver D,Bonoldi I,Rocchetti M,Gavaghan L,Patel R,McGuire P

更新日期：2018-02-15 00:00:00

abstract：:The nature and definition of schizotypy, as the latent liability for schizophrenia capable of generating various phenotypic and endophenotypic outcomes, is reviewed. The proceedings of the 2017 meeting of the International Consortium on Schizotypy Research are included in this Special Section and they are presented as...

journal_title：Schizophrenia bulletin

authors： Lenzenweger MF

更新日期：2018-10-15 00:00:00

abstract：:Negative and positive symptoms were investigated in a sample of 72 young schizophrenic and depressed patients at followup approximately 1 1/2 years after hospital discharge. Flat affect, poverty of speech, and psychomotor retardation were included as negative symptoms, and delusions, hallucinations, and florid thought...

journal_title：Schizophrenia bulletin

authors： Pogue-Geile MF,Harrow M

更新日期：1984-01-01 00:00:00

abstract：:As a result of improving technologies and greatly increased sample sizes, the last 2 years has seen unprecedented advances in identification of specific genetic risk factors for psychiatric phenotypes. Strong genetic associations have been reported at common polymorphisms within ANK3 and CACNA1C in bipolar disorder an...

journal_title：Schizophrenia bulletin

authors： Craddock N,O'Donovan MC,Owen MJ

更新日期：2009-05-01 00:00:00

abstract：:To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating hippocampal functional connectivity during resting state, using seeds prescribed in its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (S...

journal_title：Schizophrenia bulletin

authors： Kraguljac NV,White DM,Hadley N,Hadley JA,Ver Hoef L,Davis E,Lahti AC

更新日期：2016-07-01 00:00:00

abstract：:The present article reports findings on intelligence and personality functioning during the school period and at adolescence in a sample of kibbutz and urban Israeli children at risk for schizophrenia, as measured by a standard psychological test battery. On the first round of testing it was found that the index subje...

journal_title：Schizophrenia bulletin

authors： Sohlberg SC

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:ABT-288 is a highly potent histamine-3 receptor antagonist that has demonstrated pro-cognitive effects in preclinical models relevant to schizophrenia. This study evaluated the efficacy and safety of two doses of ABT-288 in the treatment of cognitive impairment associated with schizophrenia. METHODS:A ran...

journal_title：Schizophrenia bulletin

authors： Haig GM,Bain E,Robieson W,Othman AA,Baker J,Lenz RA

更新日期：2014-11-01 00:00:00

abstract：:The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior ci...

journal_title：Schizophrenia bulletin

authors： Egerton A,Murphy A,Donocik J,Anton A,Barker GJ,Collier T,Deakin B,Drake R,Eliasson E,Emsley R,Gregory CJ,Griffiths K,Kapur S,Kassoumeri L,Knight L,Lambe EJB,Lawrie SM,Lees J,Lewis S,Lythgoe DJ,Matthews J,McGuire

更新日期：2020-09-10 00:00:00

abstract：:This research studied hypotheses that positive thought disorder in schizophrenia is influenced by patients' not taking in immediate target contextual material, thereby losing vital cues that guide thought processes. We assessed 164 acute inpatients (including 55 schizophrenia and 31 bipolar disorder patients), using s...

journal_title：Schizophrenia bulletin

authors： Harrow M,Green KE,Sands JR,Jobe TH,Goldberg JF,Kaplan KJ,Martin EM

更新日期：2000-01-01 00:00:00

abstract：:Child maltreatment is a widespread public health problem associated with a range of mental health disorders later in life. In order to effectively address these disorders, there is a need to understand more about the mental health consequences of different types of child maltreatment. This study examines the associati...

journal_title：Schizophrenia bulletin

authors： Abajobir AA,Kisely S,Scott JG,Williams G,Clavarino A,Strathearn L,Najman JM

更新日期：2017-09-01 00:00:00

abstract：:Distinguishing between brain-damaged and schizophrenic patients remains a significant clinical problem. However, substantive and methodological difficulties have led to discouragement and consequent loss of interest in this area of differential diagnosis. Several models for making this distinction were proposed: cogni...

journal_title：Schizophrenia bulletin

authors： Goldstein G

更新日期：1978-01-01 00:00:00

abstract：:The dopamine hypothesis of schizophrenia is usually presented in a static, rather than dynamic fashion. We propose that increased dopaminergic activity may represent a stage of a dynamic schizophrenic process rather than its cause. Dopamine, as well as other neurotransmitters, responds in an adaptive fashion to stimul...

journal_title：Schizophrenia bulletin

authors： Csernansky JG,Holman CA,Hollister LE

更新日期：1983-01-01 00:00:00

abstract：:Psychiatric research, including the search for predisposing genes, has tended to proceed under the assumptions that schizophrenia and bipolar disorder, as defined in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and International Statistical Classification of Diseases, 10th Revision, are discr...

journal_title：Schizophrenia bulletin

authors： Owen MJ,Craddock N,Jablensky A

更新日期：2007-07-01 00:00:00

abstract：:The purpose of the study was to examine (1) to which negative symptoms schizophrenia patients attribute distress and (2) whether clinical variables can predict the levels of reported distress. With the help of a research assistant, 86 hospitalized patients completed a self-rating scale for negative symptoms. The 21 it...

journal_title：Schizophrenia bulletin

authors： Selten JP,Wiersma D,van den Bosch RJ

更新日期：2000-01-01 00:00:00

abstract：Objective:Evidence suggests that social skills training (SST) is an efficacious intervention for negative symptoms in psychosis, whereas evidence of efficacy in other psychosis symptom domains is limited. The current article reports a comprehensive meta-analytic review of the evidence for SST across relevant outcome me...

journal_title：Schizophrenia bulletin

authors： Turner DT,McGlanaghy E,Cuijpers P,van der Gaag M,Karyotaki E,MacBeth A

更新日期：2018-04-06 00:00:00

abstract：:Schizophrenia is a disorder of a neurodevelopmental origin manifested symptomatically after puberty. Structural neuroimaging studies show that neuroanatomical aberrations precede onset of symptoms, raising a question of whether schizophrenia can be prevented. Early treatment with atypical antipsychotics may reduce the...

journal_title：Schizophrenia bulletin

authors： Piontkewitz Y,Arad M,Weiner I

更新日期：2011-11-01 00:00:00

abstract：:People with serious mental illness (SMI) have mortality rates 2 to 3 times higher than the overall US population, largely due to cardiovascular disease. The prevalence of cardiovascular risk factors such as obesity and diabetes mellitus and other conditions, such as HIV/AIDS, is heightened in this group. Based on the ...

journal_title：Schizophrenia bulletin

authors： McGinty EE,Baller J,Azrin ST,Juliano-Bult D,Daumit GL

更新日期：2016-01-01 00:00:00

abstract：:Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to non...

journal_title：Schizophrenia bulletin

authors： Egerton A,Howes OD,Houle S,McKenzie K,Valmaggia LR,Bagby MR,Tseng HH,Bloomfield MA,Kenk M,Bhattacharyya S,Suridjan I,Chaddock CA,Winton-Brown TT,Allen P,Rusjan P,Remington G,Meyer-Lindenberg A,McGuire PK,Mizrahi R

更新日期：2017-03-01 00:00:00

abstract：:This study examined the relation between maternal prepregnant body mass index (BMI) and development of schizophrenia and schizophrenia spectrum disorders in adult offspring from the Prenatal Determinants of Schizophrenia Study. The study drew on a previously studied cohort of births occurring between 1959 and 1967 to ...

journal_title：Schizophrenia bulletin

authors： Schaefer CA,Brown AS,Wyatt RJ,Kline J,Begg MD,Bresnahan MA,Susser ES

更新日期：2000-01-01 00:00:00

abstract：:Schizophrenia affects people of all age groups. Treatment plans for older adults with schizophrenia must consider the effects of age on the course of the illness as well as on the response to antipsychotics and to psychosocial interventions. Positive symptoms of schizophrenia tend to become less severe, substance abus...

journal_title：Schizophrenia bulletin

authors： Jeste DV,Maglione JE

更新日期：2013-09-01 00:00:00