Distress attributed to negative symptoms in schizophrenia.

abstract：:This cross-sectional study examined the relationships between neurocognitive and social functioning in a sample of 80 outpatients with DSM-III-R schizophrenia. The neurocognitive battery included measures of verbal ability, verbal memory, visual memory, executive functioning, visual-spatial organization, vigilance, an...

journal_title：Schizophrenia bulletin

authors： Addington J,Addington D

更新日期：1999-01-01 00:00:00

abstract：:Recent years have witnessed widespread interest in the early phase of schizophrenia and other psychotic disorders. Strategies have been introduced to attempt to identify individuals in the prepsychotic or prodromal phase. The most widely used of these approaches is the ultra-high risk (UHR) approach, which combines kn...

journal_title：Schizophrenia bulletin

authors： Nelson B,Yung AR,Bechdolf A,McGorry PD

更新日期：2008-03-01 00:00:00

abstract：:A number of psychosocial treatments are available for persons with schizophrenia that include social skills training, cognitive behavioral therapy, cognitive remediation, and social cognition training. These treatments are reviewed and discussed in terms of how they address key components of functional recovery such a...

journal_title：Schizophrenia bulletin

authors： Kern RS,Glynn SM,Horan WP,Marder SR

更新日期：2009-03-01 00:00:00

abstract：:Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of a number of bioactive molecules; of principal interest to psychiatry, these include dopamine. The enzyme is encoded by the COMT gene. COMT is located (along with 47 other genes) in a fragment of chromosome 22q11 which when delete...

journal_title：Schizophrenia bulletin

authors： Williams HJ,Owen MJ,O'Donovan MC

更新日期：2007-05-01 00:00:00

abstract：:The dopamine hypothesis of schizophrenia is usually presented in a static, rather than dynamic fashion. We propose that increased dopaminergic activity may represent a stage of a dynamic schizophrenic process rather than its cause. Dopamine, as well as other neurotransmitters, responds in an adaptive fashion to stimul...

journal_title：Schizophrenia bulletin

authors： Csernansky JG,Holman CA,Hollister LE

更新日期：1983-01-01 00:00:00

abstract：:Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural...

journal_title：Schizophrenia bulletin

authors： Hirjak D,Kubera KM,Northoff G,Fritze S,Bertolino AL,Topor CE,Schmitgen MM,Wolf RC

更新日期：2019-10-24 00:00:00

abstract：:Antipsychotics, cognitive behavioral therapy (CBT), and omega-3-fatty acids have been found superior to control conditions as regards prevention of psychosis in people at-risk of first-episode psychosis. However, no large-scale trial evaluating the differential efficacy of CBT and antipsychotics has been performed yet...

journal_title：Schizophrenia bulletin

authors： Bechdolf A,Müller H,Stützer H,Wagner M,Maier W,Lautenschlager M,Heinz A,de Millas W,Janssen B,Gaebel W,Michel TM,Schneider F,Lambert M,Naber D,Brüne M,Krüger-Özgürdal S,Wobrock T,Riedel M,Klosterkötter J,PREVENT stu

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Both neurocognitive impairments and a history of childhood abuse are highly prevalent in patients with schizophrenia. Childhood trauma has been associated with memory impairment as well as hippocampal volume reduction in adult survivors. The aim of the following study was to examine the contribution of childh...

journal_title：Schizophrenia bulletin

authors： Shannon C,Douse K,McCusker C,Feeney L,Barrett S,Mulholland C

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Insight into the neural mechanisms underlying the shared and disparate features of schizophrenia (SZ) and bipolar disorder (BD) is limited. The amygdala and prefrontal cortex (PFC) appear to have crucial roles in SZ and BD, yet abnormalities appear to manifest differently in the 2 disorders. METHODS:Eightee...

journal_title：Schizophrenia bulletin

authors： Liu H,Tang Y,Womer F,Fan G,Lu T,Driesen N,Ren L,Wang Y,He Y,Blumberg HP,Xu K,Wang F

更新日期：2014-03-01 00:00:00

abstract：:We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neuroin...

journal_title：Schizophrenia bulletin

authors： Mirsky AF,Kugelmass S,Ingraham LJ,Frenkel E,Nathan M

更新日期：1995-01-01 00:00:00

abstract：:Distinguishing between brain-damaged and schizophrenic patients remains a significant clinical problem. However, substantive and methodological difficulties have led to discouragement and consequent loss of interest in this area of differential diagnosis. Several models for making this distinction were proposed: cogni...

journal_title：Schizophrenia bulletin

authors： Goldstein G

更新日期：1978-01-01 00:00:00

abstract：:Although the various manifestations of disordered thought have played a central role in diagnostic and theoretical considerations of schizophrenia, such symptoms have not been found specific to schizophrenia, and at best have shown weak relations to outcome. As part of a 7-year followup study of a sample of young, acu...

journal_title：Schizophrenia bulletin

authors： Knight RA,Elliott DS,Roff JD,Watson CG

更新日期：1986-01-01 00:00:00

abstract：:Designs of clinical trials that will permit evaluation of independent, additive, and interactive effects of drugs and psychosocial treatments are described. The central feature of such designs is that they incorporate control conditions for both classes of treatment. Data from the articles in this issue are drawn upon...

journal_title：Schizophrenia bulletin

authors： Schooler NR

更新日期：1980-01-01 00:00:00

abstract：:In a previous article in the Schizophrenia Bulletin (Vol. 22, No. 1, 1996), we presented findings of a study on the clinical and rehabilitative effects of work activity on 150 subjects diagnosed with schizophrenia or schizoaffective disorder. Subjects were randomly assigned to either a Pay ($3.40/hr) or No-Pay group a...

journal_title：Schizophrenia bulletin

authors： Bell MD,Lysaker PH

更新日期：1997-01-01 00:00:00

abstract：:This article combines a review and meta-analysis of research on IQ in schizophrenia, with emphasis on areas of convergence in the findings, as well as questions that remain to be answered. Taken together, the findings suggest that early-onset and adult-onset schizophrenia are associated with intellectual deficits acro...

journal_title：Schizophrenia bulletin

authors： Aylward E,Walker E,Bettes B

更新日期：1984-01-01 00:00:00

abstract：:The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms ...

journal_title：Schizophrenia bulletin

authors： Mueser KT,Douglas MS,Bellack AS,Morrison RL

更新日期：1991-01-01 00:00:00

abstract：:In this issue we have tried to bring together a series of reviews describing new developments in the pharmacologic management of schizophrenia. Important progress is being made not only in medication development, but also in furthering our ability to use available treatments and treatment combinations in the most effe...

journal_title：Schizophrenia bulletin

authors： Kane JM

更新日期：1991-01-01 00:00:00

abstract：:Identifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions. This article presents a selective review of findings on risk prediction algorithms and potential mechanisms of onset in youth at clinical high-risk for ...

journal_title：Schizophrenia bulletin

authors： Cannon TD

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Cannabis use is associated with a younger age at onset of psychosis, an indicator of poor prognosis, but better cognitive function, a positive prognostic indicator. We aimed to clarify the role of age at onset and cognition on outcomes in cannabis users with first-episode schizophrenia as well as the effect o...

journal_title：Schizophrenia bulletin

authors： Leeson VC,Harrison I,Ron MA,Barnes TR,Joyce EM

更新日期：2012-06-01 00:00:00

abstract：:We found diurnal weight gain to be abnormal among 93 chronically psychotic patients, most of whom had schizophrenia. They were weighed at 7 a.m. and 4 p.m. weekly for 3 weeks. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the differenc...

journal_title：Schizophrenia bulletin

authors： Vieweg WV,Godleski LS,Graham P,Kellogg EJ,Goldman F,Barber J,Bayliss EV,Glick JL,Hundley PL,Yank GR

更新日期：1989-01-01 00:00:00

abstract：INTRODUCTION:Separable, but positively correlated, factors emerge from analyses of cognitive test data in schizophrenia and control samples (eg, verbal memory and processing speed) and these factors guide data reduction. Additionally, data support a hierarchical model of cognitive performance, in which these correlatio...

journal_title：Schizophrenia bulletin

authors： Dickinson D,Goldberg TE,Gold JM,Elvevåg B,Weinberger DR

更新日期：2011-11-01 00:00:00

abstract：:Schizophrenia has been associated with heightened stress responsivity in adolescence that precedes onset of psychosis. We now report that multiple stressors during adolescence in normal rats leads to deficits in adults analogous to that seen in schizophrenia patients. Moreover, impairment of stress control by lesion o...

journal_title：Schizophrenia bulletin

authors： Gomes FV,Grace AA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. METHODS:I...

journal_title：Schizophrenia bulletin

authors： Lavigne KM,Rapin LA,Metzak PD,Whitman JC,Jung K,Dohen M,Lœvenbruck H,Woodward TS

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Impaired cognition is an important dimension in psychosis and its at-risk states. Research on the value of impaired cognition for psychosis prediction in at-risk samples, however, mainly relies on study-specific sample means of neurocognitive tests, which unlike widely available general test norms are difficu...

journal_title：Schizophrenia bulletin

authors： Michel C,Ruhrmann S,Schimmelmann BG,Klosterkötter J,Schultze-Lutter F

更新日期：2014-11-01 00:00:00

abstract：:In 1917, Eugen Bleuler published an article (Mendelismus bei Psychosen, speziell bei der Schizophrenie [Mendelism in the Psychoses, especially Schizophrenia]) in response to the recently published first systematic family study of dementia praecox (DP) by Ernst Rüdin, then working under Kraepelin in Munich. Although br...

journal_title：Schizophrenia bulletin

authors： Kendler KS

更新日期：2020-07-08 00:00:00

abstract：:Cognitive disruption in schizophrenia is associated with altered patterns of spatiotemporal interaction associated with multiple electroencephalogram (EEG) frequency bands in cortex. In particular, changes in the generation of gamma (30-80 Hz) and beta2 (20-29 Hz) rhythms correlate with observed deficits in communicat...

journal_title：Schizophrenia bulletin

authors： Roopun AK,Cunningham MO,Racca C,Alter K,Traub RD,Whittington MA

更新日期：2008-09-01 00:00:00

abstract：:The "Praecox Feeling" (PF) is a classical concept referring to a characteristic feeling of bizarreness experienced by a psychiatrist while encountering a person with schizophrenia. Although the PF used to be considered a core symptom of the schizophrenia spectrum, it fell into disuse since the spread of operationalize...

journal_title：Schizophrenia bulletin

authors： Gozé T,Moskalewicz M,Schwartz MA,Naudin J,Micoulaud-Franchi JA,Cermolacce M

更新日期：2019-09-11 00:00:00

abstract：:Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained attention in schizophrenia patients, although its neural mechanisms are unknown. Understanding the neural basis of this effect may lead to new treatment strategies for this cognitiv...

journal_title：Schizophrenia bulletin

authors： Hong LE,Schroeder M,Ross TJ,Buchholz B,Salmeron BJ,Wonodi I,Thaker GK,Stein EA

更新日期：2011-03-01 00:00:00

abstract：:Recent studies provide considerable evidence that schizophrenia and bipolar disorder may share overlapping etiologic determinants. Identifying disease-related genetic effects is a major focus in schizophrenia and bipolar disorder research, with implications for clarifying diagnosis and developing specific treatments f...

journal_title：Schizophrenia bulletin

authors： Thaker G

更新日期：2008-07-01 00:00:00

abstract：:The prodrome of psychosis has become a target for early identification and for treatments that address both symptoms and risk for future psychosis. Interest and activity in this realm is now worldwide. Clinical trials with rigorous methodology have only just begun, making treatment guidelines premature. Despite the sp...

journal_title：Schizophrenia bulletin

authors： McGlashan TH,Addington J,Cannon T,Heinimaa M,McGorry P,O'Brien M,Penn D,Perkins D,Salokangas RK,Walsh B,Woods SW,Yung A

更新日期：2007-05-01 00:00:00