Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?

abstract：:This analysis examines the notion of progressive deterioration in schizophrenia, using long-term followup data on hospital episodes in defined cohorts from psychiatric case registers in Victoria, Australia; Denmark; and Salford, England. The analyses differentiate heterogeneity existing at the first hospitalization fo...

journal_title：Schizophrenia bulletin

authors： Eaton WW,Bilker W,Haro JM,Herrman H,Mortensen PB,Freeman H,Burgess P

更新日期：1992-01-01 00:00:00

abstract：:Research on emotional processing in schizophrenia suggests relatively intact subjective responses to affective stimuli "in the moment." However, neuroimaging evidence suggests diminished activation in brain regions associated with emotional processing in schizophrenia. We asked whether given a more vulnerable cognitiv...

journal_title：Schizophrenia bulletin

authors： Becerril K,Barch D

更新日期：2011-09-01 00:00:00

abstract：:Identifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions. This article presents a selective review of findings on risk prediction algorithms and potential mechanisms of onset in youth at clinical high-risk for ...

journal_title：Schizophrenia bulletin

authors： Cannon TD

更新日期：2016-07-01 00:00:00

abstract：:Antistigma campaigns have been promoting a medical view of schizophrenia. Given the growing body of research finding negative associations between biogenetic (BG) causal attributions and stigmatizing attitudes, this approach must be reappraised. The present study investigates the impact of different psychoeducational ...

journal_title：Schizophrenia bulletin

authors： Lincoln TM,Arens E,Berger C,Rief W

更新日期：2008-09-01 00:00:00

abstract：:Although the various manifestations of disordered thought have played a central role in diagnostic and theoretical considerations of schizophrenia, such symptoms have not been found specific to schizophrenia, and at best have shown weak relations to outcome. As part of a 7-year followup study of a sample of young, acu...

journal_title：Schizophrenia bulletin

authors： Knight RA,Elliott DS,Roff JD,Watson CG

更新日期：1986-01-01 00:00:00

abstract：:Recent studies provide considerable evidence that schizophrenia and bipolar disorder may share overlapping etiologic determinants. Identifying disease-related genetic effects is a major focus in schizophrenia and bipolar disorder research, with implications for clarifying diagnosis and developing specific treatments f...

journal_title：Schizophrenia bulletin

authors： Thaker G

更新日期：2008-07-01 00:00:00

abstract：:Negative and positive symptoms were investigated in a sample of 72 young schizophrenic and depressed patients at followup approximately 1 1/2 years after hospital discharge. Flat affect, poverty of speech, and psychomotor retardation were included as negative symptoms, and delusions, hallucinations, and florid thought...

journal_title：Schizophrenia bulletin

authors： Pogue-Geile MF,Harrow M

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:Stressful life events have been implicated in the onset of psychotic disorders, but there are few robust studies. We sought to examine the nature and magnitude of associations between adult life events and difficulties and first-episode psychoses, particularly focusing on contextual characteristics, including...

journal_title：Schizophrenia bulletin

authors： Beards S,Fisher HL,Gayer-Anderson C,Hubbard K,Reininghaus U,Craig TJ,Di Forti M,Mondelli V,Pariante C,Dazzan P,Murray R,Morgan C

更新日期：2020-07-08 00:00:00

abstract：:The authors describe an easily administered scale being developed to assess the rejecting feelings of family respondents toward former mental patients who return to live with their families. Based upon a sample of 133 discharged mental patients and family members, the scale demonstrates a moderately high reliability (...

journal_title：Schizophrenia bulletin

authors： Kreisman DE,Simmens SJ,Joy VD

更新日期：1979-01-01 00:00:00

abstract：:Disruption of sleep/wake cycles is common in patients with schizophrenia and correlates with cognitive and affective abnormalities. Mice deficient in stable tubule only polypeptide (STOP) show cognitive, behavioral, and neurobiological deficits that resemble those seen in patients with schizophrenia, but little is kno...

journal_title：Schizophrenia bulletin

authors： Profitt MF,Deurveilher S,Robertson GS,Rusak B,Semba K

更新日期：2016-09-01 00:00:00

abstract：:A selective review of the negative symptoms of schizophrenia is an appropriate article to result from the festschrift honoring William T. Carpenter Jr, as he has made substantial contributions in this area. This review assesses progress in 3 areas in which he has been an important investigator: the distinction between...

journal_title：Schizophrenia bulletin

authors： Kirkpatrick B

更新日期：2014-03-01 00:00:00

abstract：:The question of whether schizophrenia is associated with structural or functional abnormalities of the nervous system, or both, has become the principal focus of biological studies of schizophrenia. Computed tomography studies have revealed ventricular enlargement and cortical atrophy in a subgroup of schizophrenic pa...

journal_title：Schizophrenia bulletin

authors： Meltzer HY

更新日期：1987-01-01 00:00:00

abstract：:A substantial proportion of patients with schizophrenia experience the onset of their illness by age 18. Data from phenomenological, cognitive, neuroimaging, and genetic studies suggest a similar profile of clinical and neurobiological abnormalities between early- and adult-onset patients. However, children and adoles...

journal_title：Schizophrenia bulletin

authors： Kumra S,Charles Schulz S

更新日期：2008-01-01 00:00:00

abstract：:The literature on schizophrenia has reported a trend toward higher concordance rates for females in both monozygotic and dizygotic same-sexed twins. The validity of this finding is open to question. Rosenthal (1961 and 1962) pointed out that females are more likely than males to become inhabitants of chronic wards. Mo...

journal_title：Schizophrenia bulletin

authors： Samuels L

更新日期：1978-01-01 00:00:00

abstract：:One neuropathological feature of schizophrenia is a diminished number of dendritic spines in the prefrontal cortex and hippocampus. The neuregulin 1 (Nrg1) system is involved in the plasticity of dendritic spines, and chronic stress decreases dendritic spine densities in the prefrontal cortex and hippocampus. Here, we...

journal_title：Schizophrenia bulletin

authors： Clarke DJ,Chohan TW,Kassem MS,Smith KL,Chesworth R,Karl T,Kuligowski MP,Fok SY,Bennett MR,Arnold JC

更新日期：2019-03-07 00:00:00

abstract：:Secondary sources continue to cite a one-page preliminary note about the Michigan State Psychotherapy Project, ignoring fuller reports in print. Relevant experience and training are critical to quality control of psychotherapy in schizophrenia research. This investigation is unique in that "experienced" meant that the...

journal_title：Schizophrenia bulletin

authors： Karon BP

更新日期：1978-01-01 00:00:00

abstract：:The current study sought to examine the underlying brain changes in individuals with high schizotypy by integrating networks derived from brain structural and functional imaging. Individuals with high schizotypy (n = 35) and low schizotypy (n = 34) controls were screened using the Schizotypal Personality Questionnaire...

journal_title：Schizophrenia bulletin

authors： Wang Y,Yan C,Yin DZ,Fan MX,Cheung EF,Pantelis C,Chan RC

更新日期：2015-03-01 00:00:00

abstract：:Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural...

journal_title：Schizophrenia bulletin

authors： Hirjak D,Kubera KM,Northoff G,Fritze S,Bertolino AL,Topor CE,Schmitgen MM,Wolf RC

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:Similar to patients with other chronic disorders, patients with serious mental illness (SMI) are often poorly adherent with prescribed medications. OBJECTIVE:We conducted a randomized controlled trial examining the effectiveness of a pharmacy-based intervention (Meds-Help) in increasing antipsychotic medica...

journal_title：Schizophrenia bulletin

authors： Valenstein M,Kavanagh J,Lee T,Reilly P,Dalack GW,Grabowski J,Smelson D,Ronis DL,Ganoczy D,Woltmann E,Metreger T,Wolschon P,Jensen A,Poddig B,Blow FC

更新日期：2011-07-01 00:00:00

abstract：:A critique is offered of Samuels' article suggesting that reported sex differences in concordance rates for schizophrenia are either methodological artifacts or a function of sociological processes. Evidence of sex differences in age of onset, clinical expression, concordance rates among primary relatives, and premorb...

journal_title：Schizophrenia bulletin

authors： Lewine RR

更新日期：1979-01-01 00:00:00

abstract：:Deluded people differ from nondeluded controls on attributional style questionnaires and probabilistic-reasoning and theory-of-mind (ToM) tasks. No study to date has examined the relations between these 3 reasoning anomalies in the same individuals so as to evaluate their functional independence and potentially inform...

journal_title：Schizophrenia bulletin

authors： Langdon R,Ward PB,Coltheart M

更新日期：2010-03-01 00:00:00

abstract：Background:Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to ...

journal_title：Schizophrenia bulletin

authors： Peralta V,Cuesta MJ

更新日期：2017-09-01 00:00:00

abstract：:Mobile assessment techniques have been used for nearly 3 decades in mental health research, including in investigations of individuals with schizophrenia and other severe disorders. This article reviews the benefits of these data collection strategies relative to traditional self-report or clinician-administered measu...

journal_title：Schizophrenia bulletin

authors： Kimhy D,Myin-Germeys I,Palmier-Claus J,Swendsen J

更新日期：2012-05-01 00:00:00

abstract：:The purpose of this study was to assess how neurocognition and social cognition were associated with initial functional level and with rates of functional change in intensive community-based psychosocial rehabilitation interventions that have been shown to yield significant functional change for individuals diagnosed ...

journal_title：Schizophrenia bulletin

authors： Brekke JS,Hoe M,Long J,Green MF

更新日期：2007-09-01 00:00:00

abstract：:To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating hippocampal functional connectivity during resting state, using seeds prescribed in its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (S...

journal_title：Schizophrenia bulletin

authors： Kraguljac NV,White DM,Hadley N,Hadley JA,Ver Hoef L,Davis E,Lahti AC

更新日期：2016-07-01 00:00:00

abstract：:Similarities in clinical course, age of onset, geographical distribution, and immunological responses of patients with schizophrenia and multiple sclerosis (MS) suggest that these two common illnesses of young adults may belong to a similar class of disorders. This review examines some of the similarities and differen...

journal_title：Schizophrenia bulletin

authors： Stevens JR

更新日期：1988-01-01 00:00:00

abstract：:One of the main questions related to schizophrenia is, naturally enough, what is it? Such a question may seem obvious, naive, impossible, or any combination of these. And certainly it is a bit demanding to expect that anyone could say what schizophrenia is in 1,000 words. On the other hand, we felt that it was worth t...

journal_title：Schizophrenia bulletin

authors： Meltzer HY,Liberman RP

更新日期：1982-01-01 00:00:00

abstract：:The purpose of this study was (1) to identify the demographic and psychosocial characteristics of Korean-Americans with schizophrenia, and (2) to compare the demographic and psychosocial characteristics of Korean-Americans with schizophrenia to African-American, Latino, and Euro-American individuals with schizophrenia...

journal_title：Schizophrenia bulletin

authors： Bae SW,Brekke JS

更新日期：2002-01-01 00:00:00

abstract：:Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...

journal_title：Schizophrenia bulletin

authors： Gong Q,Dazzan P,Scarpazza C,Kasai K,Hu X,Marques TR,Iwashiro N,Huang X,Murray RM,Koike S,David AS,Yamasue H,Lui S,Mechelli A

更新日期：2015-11-01 00:00:00

abstract：:Individuals with psychoses have brain alterations, particularly in frontal and temporal cortices, that may be particularly prominent, already at illness onset, in those more likely to have poorer symptom remission following treatment with the first antipsychotic. The identification of strong neuroanatomical markers of...

journal_title：Schizophrenia bulletin

authors： Dazzan P,Lawrence AJ,Reinders AATS,Egerton A,van Haren NEM,Merritt K,Barker GJ,Perez-Iglesias R,Sendt KV,Demjaha A,Nam KW,Sommer IE,Pantelis C,Wolfgang Fleischhacker W,van Rossum IW,Galderisi S,Mucci A,Drake R,Lewis S

更新日期：2020-10-15 00:00:00