Abstract：
:In light of the large number of studies published since the 2004 update of Schizophrenia Patient Outcomes Research Team psychopharmacological treatment recommendations, we conducted an extensive literature review to determine whether the current psychopharmacological treatment recommendations required revision and whether there was sufficient evidence to warrant new treatment recommendations for prespecified outcomes of interest. We reviewed over 400 articles, which resulted in 16 treatment recommendations: the revision of 11 previous treatment recommendations and 5 new treatment recommendations. Three previous treatment recommendations were eliminated. There were 13 interventions and/or outcomes for which there was insufficient evidence for a treatment recommendation, and a statement was written to summarize the current level of evidence and identify important gaps in our knowledge that need to be addressed. In general, there was considerable consensus among the Psychopharmacology Evidence Review Group and the expert consultants. Two major areas of contention concerned whether there was sufficient evidence to recommend specific dosage ranges for the acute and maintenance treatment of first-episode and multi-episode schizophrenia and to endorse the practice of switching antipsychotics for the treatment of antipsychotic-related weight gain. Finally, there continue to be major gaps in our knowledge, including limited information on (1) the use of adjunctive pharmacological agents for the treatment of persistent positive symptoms or other symptom domains of psychopathology, including anxiety, cognitive impairments, depressive symptoms, and persistent negative symptoms and (2) the treatment of co-occurring substance or medical disorders that occur frequently in individuals with schizophrenia.
journal_name
Schizophr Bulljournal_title
Schizophrenia bulletinauthors
Buchanan RW,Kreyenbuhl J,Kelly DL,Noel JM,Boggs DL,Fischer BA,Himelhoch S,Fang B,Peterson E,Aquino PR,Keller W,Schizophrenia Patient Outcomes Research Team (PORT).doi
10.1093/schbul/sbp116subject
Has Abstractpub_date
2010-01-01 00:00:00pages
71-93issue
1eissn
0586-7614issn
1745-1701pii
sbp116journal_volume
36pub_type
共识发展会议,杂志文章,实务指引,评审abstract：:In this issue we have tried to bring together a series of reviews describing new developments in the pharmacologic management of schizophrenia. Important progress is being made not only in medication development, but also in furthering our ability to use available treatments and treatment combinations in the most effe...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/17.2.193
更新日期：1991-01-01 00:00:00
abstract：:The dopamine hypothesis of schizophrenia is usually presented in a static, rather than dynamic fashion. We propose that increased dopaminergic activity may represent a stage of a dynamic schizophrenic process rather than its cause. Dopamine, as well as other neurotransmitters, responds in an adaptive fashion to stimul...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/9.3.325
更新日期：1983-01-01 00:00:00
abstract：:As part of a long-term study in schizophrenia, a model of family intervention has been developed which attempts to diminish relapse rates of schizophrenic patients. This model reflects theoretical and research findings which suggest that certain patients have a "core psychological deficit" that might increase vulnerab...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/6.3.490
更新日期：1980-01-01 00:00:00
abstract：:Schizophrenia elevates the risk for aggressive behavior and violent crime, and different approaches have been used to manage this problem. The results of such treatments vary. One reason for this variation is that aggressive behavior in schizophrenia is heterogeneous in origin. This heterogeneity has usually not been ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/sbr041
更新日期：2011-09-01 00:00:00
abstract：:The rapid embracing of artificial intelligence in psychiatry has a flavor of being the current "wild west"; a multidisciplinary approach that is very technical and complex, yet seems to produce findings that resonate. These studies are hard to review as the methods are often opaque and it is tricky to find the suitabl...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbz105
更新日期：2020-01-04 00:00:00
abstract：:Between 5% and 10% of people with psychosis will die by suicide, a rate which is 20-75 times higher than the general population. This risk is even greater in those not taking antipsychotic medication. We examined whether negative appraisals of psychotic experiences and negative metacognitive beliefs about losing menta...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,随机对照试验
doi：10.1093/schbul/sby153
更新日期：2019-01-01 00:00:00
abstract：UNLABELLED:We aimed to discover whether metabolic complications of schizophrenia (SZ) are present in first episode (FE) and unmedicated (UM) patients, in comparison with patients established on antipsychotic medication (AP). METHOD:A systematic search, critical appraisal, and meta-analysis were conducted of studies to...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,meta分析,评审
doi：10.1093/schbul/sbs082
更新日期：2013-03-01 00:00:00
abstract：:Pharmacologic agents currently used or being studied for the treatment of schizophrenia are reviewed. Neuroleptic medications are still the mainstay of treatment, but recent studies suggest new approaches to dosage and to the treatment of acute psychosis. Lithium is beneficial in psychotic illnesses with acute onset a...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/9.4.504
更新日期：1983-01-01 00:00:00
abstract：:To better characterize hippocampal pathophysiology in schizophrenia, we conducted a longitudinal study evaluating hippocampal functional connectivity during resting state, using seeds prescribed in its anterior and posterior regions. We enrolled 34 unmedicated patients with schizophrenia or schizoaffective disorder (S...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbv228
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Deficits in emotion processing are thought to underlie the key negative symptoms flat affect and anhedonia observed in psychotic disorders. This study investigated emotional experience and social behavior in the realm of daily life in a sample of patients with schizophrenia and schizoaffective disorder, stra...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbr137
更新日期：2013-01-01 00:00:00
abstract：:The two indices that have been proposed for quantifying the accuracy of smooth-following eye movements are shown to be interchangeable. This algebraic fact will permit comparability of values between laboratories only if workers who employ the signal-to-noise ratio (S/N) as their index measure S and N as the total sig...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/7.2.204
更新日期：1981-01-01 00:00:00
abstract：:Randomized controlled trials for antipsychotic drugs have a variety of design features suited to diverse purposes. Efficacy (or explanatory) trials seek to establish if a drug can reduce psychotic symptoms under ideal circumstances. To isolate drug effects, researchers enroll carefully selected patients. Specialized r...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/sbm156
更新日期：2008-03-01 00:00:00
abstract：:Psychotic experiences may be understood as altered information processing due to aberrant neural computations. A prominent example of such neural computations is the computation of prediction errors (PEs), which signal the difference between expected and experienced events. Among other areas showing PE coding, hippoca...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/sby154
更新日期：2019-09-11 00:00:00
abstract：:We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neuroin...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/21.2.227
更新日期：1995-01-01 00:00:00
abstract：Objective:A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to the pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) and related comorbidities. We investigated the relative distribution of TNF-related molecules in blood and dorsolateral prefrontal cortex (DLPFC) in these...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbw183
更新日期：2017-07-01 00:00:00
abstract：:This article combines a review and meta-analysis of research on IQ in schizophrenia, with emphasis on areas of convergence in the findings, as well as questions that remain to be answered. Taken together, the findings suggest that early-onset and adult-onset schizophrenia are associated with intellectual deficits acro...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/10.3.430
更新日期：1984-01-01 00:00:00
abstract：:Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of a number of bioactive molecules; of principal interest to psychiatry, these include dopamine. The enzyme is encoded by the COMT gene. COMT is located (along with 47 other genes) in a fragment of chromosome 22q11 which when delete...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/sbm019
更新日期：2007-05-01 00:00:00
abstract：:In a prospective study involving 161 patients discharged from inpatient psychiatric treatment, outcome data were obtained for 93 percent of the patients 1 year after clinic discharge. Sixty-seven percent of the patients were directly interviewed for the followup examination. Outcome data for symptomatology, relapses, ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/13.2.287
更新日期：1987-01-01 00:00:00
abstract：:In addition to introducing the six articles joined by our thematic outlook, this article addresses the importance of subcortical structures as they may be related to information processing and the life experience of schizophrenic patients. This is a heuristic exercise aimed at bridging the conceptual gaps between clin...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/13.4.555
更新日期：1987-01-01 00:00:00
abstract：:The validity of a Hindi version of the Diagnostic Interview for Genetic Studies (DIGS) was investigated. The original English version was initially translated into Hindi. The Hindi version was then back-translated and compared with the original. Next, a group of psychiatric inpatients and outpatients were interviewed ...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/oxfordjournals.schbul.a033343
更新日期：1998-01-01 00:00:00
abstract：:Schizophrenia affects people of all age groups. Treatment plans for older adults with schizophrenia must consider the effects of age on the course of the illness as well as on the response to antipsychotics and to psychosocial interventions. Positive symptoms of schizophrenia tend to become less severe, substance abus...
journal_title：Schizophrenia bulletin
pub_type： 评论,杂志文章
doi：10.1093/schbul/sbt043
更新日期：2013-09-01 00:00:00
abstract：:Hallucinations in children and adolescents are now known to occur on a continuum from healthy to psychopathology-related phenomena. Although hallucinations in young populations are mostly transient, they can cause substantial distress. Despite hallucinations being widely investigated, research so far has had limited i...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sby119
更新日期：2019-02-01 00:00:00
abstract：:Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric dise...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbw159
更新日期：2017-09-01 00:00:00
abstract：:The rate of substance-use disorders in patients with mental illnesses within the psychotic spectrum, such as schizophrenia, schizoaffective disorder, and bipolar disorder, is higher than the rate observed in the general population and is associated with significant morbidity and mortality. Although there are currently...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,随机对照试验
doi：10.1093/schbul/sbl010
更新日期：2006-10-01 00:00:00
abstract：:Patients with schizophrenia can sometimes report strange face illusions when staring at themselves in the mirror; such experiences have been conceptualized as anomalous self-experiences that can be experienced with a varying degree of depersonalization. During adolescence, anomalous self-experiences can also be indica...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbu196
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:Both neurocognitive impairments and a history of childhood abuse are highly prevalent in patients with schizophrenia. Childhood trauma has been associated with memory impairment as well as hippocampal volume reduction in adult survivors. The aim of the following study was to examine the contribution of childh...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbp096
更新日期：2011-05-01 00:00:00
abstract：INTRODUCTION:Abnormalities in the neurophysiological measures P300 amplitude and latency constitute endophenotypes for psychosis. Disrupted-in-Schizophrenia-1 (DISC1) has been proposed as a promising susceptibility gene for schizophrenia, and a previous study has suggested that it is associated with P300 deficits in sc...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/sbr101
更新日期：2013-01-01 00:00:00
abstract：:A critique is offered of Samuels' article suggesting that reported sex differences in concordance rates for schizophrenia are either methodological artifacts or a function of sociological processes. Evidence of sex differences in age of onset, clinical expression, concordance rates among primary relatives, and premorb...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/5.1.4
更新日期：1979-01-01 00:00:00
abstract：:Schizophrenia has been associated with heightened stress responsivity in adolescence that precedes onset of psychosis. We now report that multiple stressors during adolescence in normal rats leads to deficits in adults analogous to that seen in schizophrenia patients. Moreover, impairment of stress control by lesion o...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章,评审
doi：10.1093/schbul/sbx033
更新日期：2017-05-01 00:00:00
abstract：:Discussion of the positive vs. negative distinction often fails to address whether this distinction refers to symptoms, syndromes, or diseases. Symptoms and syndromes are etiologically nonspecific, while diseases have a specific identifiable pathophysiology or etiology. The positive vs. negative distinction is sometim...
journal_title：Schizophrenia bulletin
pub_type： 杂志文章
doi：10.1093/schbul/11.3.380
更新日期：1985-01-01 00:00:00
