The phenomenological critique and self-disturbance: implications for ultra-high risk ("prodrome") research.

Abstract:

:Recent years have witnessed widespread interest in the early phase of schizophrenia and other psychotic disorders. Strategies have been introduced to attempt to identify individuals in the prepsychotic or prodromal phase. The most widely used of these approaches is the ultra-high risk (UHR) approach, which combines known trait and state risk factors for psychotic disorder. However, researchers guided by phenomenological theory have argued that modern psychiatry's neglect of subjective experience has compromised researchers' understanding of psychotic disorder and has thereby limited efforts at prospective and early identification. Phenomenological research indicates that disturbance of the basic sense of self may be a core marker of psychotic vulnerability, particularly of schizophrenia spectrum disorders. It is argued that identifying self-disturbance in the UHR population may provide a means of further "closing in" on individuals truly at high risk of psychotic disorder, thus supplementing the UHR identification approach. This would be of practical value in the sense of reducing inclusion of "false-positive" cases in UHR samples and of theoretical value in the sense of shedding light on core features of psychotic pathology. The strong explanatory power and empirical findings to date invite further research into the role of self-disturbance as a phenotypic vulnerability marker for psychotic disorder.

journal_name

Schizophr Bull

journal_title

Schizophrenia bulletin

authors

Nelson B,Yung AR,Bechdolf A,McGorry PD

doi

10.1093/schbul/sbm094

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

381-92

issue

2

eissn

0586-7614

issn

1745-1701

pii

sbm094

journal_volume

34

pub_type

杂志文章,评审
  • The impact of education about schizophrenia on relatives varying in expressed emotion.

    abstract::The demand for information by relatives and the success of family intervention programs with an initial didactic component has resulted in a proliferation of educational interventions in schizophrenia. The present study assesses the impact of a single educational session on relatives of recent-onset schizophrenic pati...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/14.4.675

    authors: Cozolino LJ,Goldstein MJ,Nuechterlein KH,West KL,Snyder KS

    更新日期:1988-01-01 00:00:00

  • Intelligence in schizophrenia: meta-analysis of the research.

    abstract::This article combines a review and meta-analysis of research on IQ in schizophrenia, with emphasis on areas of convergence in the findings, as well as questions that remain to be answered. Taken together, the findings suggest that early-onset and adult-onset schizophrenia are associated with intellectual deficits acro...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/10.3.430

    authors: Aylward E,Walker E,Bettes B

    更新日期:1984-01-01 00:00:00

  • The epidemiology of late-onset schizophrenia.

    abstract::We report an analysis of a large catchment area sample of patients with nonaffective functional psychoses presenting across all ages at onset. The male:female ratio was 1.56:1 in the 16-25-year age group; it reached unity around 30 years of age and declined to 0.38:1 in the 66-75-year group. Contrary to expectation, a...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/19.4.691

    authors: Castle DJ,Murray RM

    更新日期:1993-01-01 00:00:00

  • An industry perspective on the NIMH consensus statement on negative symptoms.

    abstract::Negative symptoms of schizophrenia remain an area of substantial unmet clinical need. By convening a consensus conference in January 2005, the NIMH has taken a leading role in stimulating a resurgence of interest in methodological considerations related to development of new medications for treating negative symptoms....

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbj056

    authors: Alphs L

    更新日期:2006-04-01 00:00:00

  • Stages of change in smokers with schizophrenia or schizoaffective disorder and in the general population.

    abstract::This study compared smoking behavior and motivation to quit smoking, assessed with a "stages of change" questionnaire, in outpatients with schizophrenia or schizoaffective disorder and in a representative sample of the general population. We conducted a mail survey in a representative sample of the general population ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a007092

    authors: Etter M,Mohr S,Garin C,Etter JF

    更新日期:2004-01-01 00:00:00

  • The relevance of empirical research in bioethics.

    abstract::Empirical research related to ethical issues in clinical research has grown dramatically in recent years. However, little attention has been devoted to the ethical relevance of the findings from this research. In order to examine the value and limitations of ethics-related empirical research, we discuss 3 case studies...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbj004

    authors: Miller FG,Wendler D

    更新日期:2006-01-01 00:00:00

  • Substance use disorder in hospitalized severely mentally ill psychiatric patients: prevalence, correlates, and subgroups.

    abstract::The prevalence and demographic and clinical correlates of lifetime substance use disorders were examined in a cohort of 325 recently hospitalized psychiatric patients (53% schizophrenia or schizoaffective disorder). Alcohol use was the most common type of substance use disorder, followed by cannabis and cocaine use. U...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a033438

    authors: Mueser KT,Yarnold PR,Rosenberg SD,Swett C Jr,Miles KM,Hill D

    更新日期:2000-01-01 00:00:00

  • Neurological Soft Signs Predict Auditory Verbal Hallucinations in Patients With Schizophrenia.

    abstract::Neurological soft signs (NSS) are well documented in individuals with schizophrenia (SZ), yet so far, the relationship between NSS and specific symptom expression is unclear. We studied 76 SZ patients using magnetic resonance imaging (MRI) to determine associations between NSS, positive symptoms, gray matter volume (G...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbaa146

    authors: Wolf RC,Rashidi M,Schmitgen MM,Fritze S,Sambataro F,Kubera KM,Hirjak D

    更新日期:2020-10-24 00:00:00

  • Association between learning capabilities and practice-related activation changes in schizophrenia.

    abstract::The present functional magnetic resonance imaging study investigated the neural correlates of practice-associated activation changes in patients with schizophrenia and their association with symptom severity. A group of patients (n = 24) were divided into more successful and less successful learners and were asked to ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbq028

    authors: Koch K,Wagner G,Schachtzabel C,Schultz C,Sauer H,Schlösser RG

    更新日期:2010-05-01 00:00:00

  • The Relationship Between Dissociation and Symptoms of Psychosis: A Meta-analysis.

    abstract::Evidence suggests that dissociation is associated with psychotic experiences, particularly hallucinations, but also other symptoms. However, until now, symptom-specific relationships with dissociation have not been comprehensively synthesized. This is the first prospectively registered (CRD42017058214) meta-analysis t...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbaa037

    authors: Longden E,Branitsky A,Moskowitz A,Berry K,Bucci S,Varese F

    更新日期:2020-03-18 00:00:00

  • Nonresponding schizophrenia: differentiation by neurological soft signs and neuropsychological tests.

    abstract::Schizophrenia patients have higher scores on neurological soft-signs (NSS) and show greater deficits on a variety of neuropsychological tests than normal control subjects and mixed groups of psychiatric patients. Among chronic schizophrenia patients it is unclear which of these types of deficits most strongly differen...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a033421

    authors: Smith RC,Kadewari RP,Rosenberger JR,Bhattacharyya A

    更新日期:1999-01-01 00:00:00

  • Myelination of cortical-hippocampal relays during late adolescence.

    abstract::The normal developmental series of brains in the Yakovlev Collection has been examined to explore the possibility that various brain regions implicated in schizophrenia may show changes in myelination during late adolescence, a period coinciding with the appearance of early symptoms of this disorder. The prefrontal, c...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/15.4.585

    authors: Benes FM

    更新日期:1989-01-01 00:00:00

  • Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia.

    abstract::The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbm093

    authors: Perrin MC,Brown AS,Malaspina D

    更新日期:2007-11-01 00:00:00

  • A Randomized Controlled Trial of Group Coping-Oriented Therapy vs Supportive Therapy in Schizophrenia: Results of a 2-Year Follow-up.

    abstract:OBJECTIVE:Over the past 30 years, illness management programs and cognitive-behavioral therapy for psychosis have gained prominence in the treatment of schizophrenia. However, little is known about the long-term benefits of these types of programs when delivered during inpatient treatment following a symptom exacerbati...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/schbul/sbw032

    authors: Schaub A,Mueser KT,von Werder T,Engel R,Möller HJ,Falkai P

    更新日期:2016-07-01 00:00:00

  • Clinical, functional, and economic ramifications of early nonresponse to antipsychotics in the naturalistic treatment of schizophrenia.

    abstract:OBJECTIVE:Early nonresponse to antipsychotics appears to predict subsequent nonresponse to treatment when assessed in randomized controlled trials of predominately acute inpatients treated for schizophrenia. This study assessed the predictive accuracy of early nonresponse to treatment and its clinical, functional, and ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/schbul/sbm134

    authors: Ascher-Svanum H,Nyhuis AW,Faries DE,Kinon BJ,Baker RW,Shekhar A

    更新日期:2008-11-01 00:00:00

  • Schizophrenic delusions: a phenomenological approach.

    abstract::The issue of specificity of delusions in schizophrenia is still a matter of debate. The authors analyze the delusion formation in schizophrenia from a prototypical, phenomenological point of view, focusing on the subject's experience. This perspective links delusion formation to the autistic predisposition, which is c...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/19.3.579

    authors: Bovet P,Parnas J

    更新日期:1993-01-01 00:00:00

  • Prevalence of substance abuse in schizophrenia: demographic and clinical correlates.

    abstract::Methodological issues involved in assessing the prevalence of substance abuse in schizophrenia are discussed, and previous research in this area is comprehensively reviewed. Many studies suffer from methodological shortcomings, including the lack of diagnostic rigor, adequate sample sizes, and simultaneous assessment ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/16.1.31

    authors: Mueser KT,Yarnold PR,Levinson DF,Singh H,Bellack AS,Kee K,Morrison RL,Yadalam KG

    更新日期:1990-01-01 00:00:00

  • How families evaluate mental health professionals, resources, and effects of illness.

    abstract::Evaluations by families (of chronically mentally ill individuals) of mental health professionals and resources were solicited through a mail survey. The respondents, largely better educated, white, and female, indicated a generally high level of dissatisfaction. Emotional support, information, and aftercare resources ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/8.4.626

    authors: Holden DF,Lewine RR

    更新日期:1982-01-01 00:00:00

  • Biological studies in schizophrenia.

    abstract::The question of whether schizophrenia is associated with structural or functional abnormalities of the nervous system, or both, has become the principal focus of biological studies of schizophrenia. Computed tomography studies have revealed ventricular enlargement and cortical atrophy in a subgroup of schizophrenic pa...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/13.1.77

    authors: Meltzer HY

    更新日期:1987-01-01 00:00:00

  • Social cognitive impairments and negative symptoms in schizophrenia: are there subtypes with distinct functional correlates?

    abstract::Social cognitive impairments and negative symptoms are core features of schizophrenia closely associated with impaired community functioning. However, little is known about whether these are independent dimensions of illness and if so, whether individuals with schizophrenia can be meaningfully classified based on thes...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbr125

    authors: Bell MD,Corbera S,Johannesen JK,Fiszdon JM,Wexler BE

    更新日期:2013-01-01 00:00:00

  • Impaired attention, genetics, and the pathophysiology of schizophrenia.

    abstract::Impaired attention is commonly observed among schizophrenia patients and those at genetic risk for the disease. This article reviews over 40 studies that used various versions of the Continuous Performance Test (CPT) as the primary measure of attention. These studies of normal subjects, affected patients, and various ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/20.1.31

    authors: Cornblatt BA,Keilp JG

    更新日期:1994-01-01 00:00:00

  • Sex differences in schizophrenia: a commentary.

    abstract::A critique is offered of Samuels' article suggesting that reported sex differences in concordance rates for schizophrenia are either methodological artifacts or a function of sociological processes. Evidence of sex differences in age of onset, clinical expression, concordance rates among primary relatives, and premorb...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/5.1.4

    authors: Lewine RR

    更新日期:1979-01-01 00:00:00

  • The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2003.

    abstract::Since publication of the original Schizophrenia Patient Outcomes Research Team (PORT) treatment recommendations in 1998, considerable scientific advances have occurred in our knowledge about how to help persons with schizophrenia. Today an even stronger body of research supports the scientific basis of treatment. This...

    journal_title:Schizophrenia bulletin

    pub_type: 指南,杂志文章,实务指引

    doi:10.1093/oxfordjournals.schbul.a007071

    authors: Lehman AF,Kreyenbuhl J,Buchanan RW,Dickerson FB,Dixon LB,Goldberg R,Green-Paden LD,Tenhula WN,Boerescu D,Tek C,Sandson N,Steinwachs DM

    更新日期:2004-01-01 00:00:00

  • Cost-effectiveness of alternative approaches in treating severely mentally ill in California.

    abstract::Given the rising costs of health care and the decrease in public expenditures on mental health care, policy-makers and program managers must identify cost-effective approaches for treating severely mentally ill patients. During the last year, there have been two major cost-effectiveness studies implemented in Californ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/17.3.461

    authors: Hu TW,Jerrell J

    更新日期:1991-01-01 00:00:00

  • Changing attitudes about schizophrenia.

    abstract::Research on the effectiveness of short-term education programs in changing societal attitudes about mental illness has been mixed. Education efforts seem to be mediated by characteristics of the program participants. This study determines whether the effects of a specially prepared, semester-long course on severe ment...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.schbul.a033392

    authors: Holmes EP,Corrigan PW,Williams P,Canar J,Kubiak MA

    更新日期:1999-01-01 00:00:00

  • Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis.

    abstract::Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to non...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbw181

    authors: Egerton A,Howes OD,Houle S,McKenzie K,Valmaggia LR,Bagby MR,Tseng HH,Bloomfield MA,Kenk M,Bhattacharyya S,Suridjan I,Chaddock CA,Winton-Brown TT,Allen P,Rusjan P,Remington G,Meyer-Lindenberg A,McGuire PK,Mizrahi R

    更新日期:2017-03-01 00:00:00

  • Pathways to aggression in schizophrenia affect results of treatment.

    abstract::Schizophrenia elevates the risk for aggressive behavior and violent crime, and different approaches have been used to manage this problem. The results of such treatments vary. One reason for this variation is that aggressive behavior in schizophrenia is heterogeneous in origin. This heterogeneity has usually not been ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审

    doi:10.1093/schbul/sbr041

    authors: Volavka J,Citrome L

    更新日期:2011-09-01 00:00:00

  • Effectiveness of sulpiride in adult patients with schizophrenia.

    abstract::The objective of this study is to compare the effectiveness among sulpiride, risperidone, olanzapine, and haloperidol by evaluating the persistence of drug use. A retrospective cohort study was conducted by analyzing the National Health Insurance Research Database of Taiwan. Patients with schizophrenia aged 18-65 year...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbs002

    authors: Lai EC,Chang CH,Kao Yang YH,Lin SJ,Lin CY

    更新日期:2013-05-01 00:00:00

  • Dopamine and Glutamate in Antipsychotic-Responsive Compared With Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA).

    abstract::The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior ci...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sbaa128

    authors: Egerton A,Murphy A,Donocik J,Anton A,Barker GJ,Collier T,Deakin B,Drake R,Eliasson E,Emsley R,Gregory CJ,Griffiths K,Kapur S,Kassoumeri L,Knight L,Lambe EJB,Lawrie SM,Lees J,Lewis S,Lythgoe DJ,Matthews J,McGuire

    更新日期:2020-09-10 00:00:00

  • Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

    abstract::Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size. We conducted a GWAS in the Japanese (JPN) population (a) to detect novel SCZ-susceptibility gene...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章

    doi:10.1093/schbul/sby140

    authors: Ikeda M,Takahashi A,Kamatani Y,Momozawa Y,Saito T,Kondo K,Shimasaki A,Kawase K,Sakusabe T,Iwayama Y,Toyota T,Wakuda T,Kikuchi M,Kanahara N,Yamamori H,Yasuda Y,Watanabe Y,Hoya S,Aleksic B,Kushima I,Arai H,Takaki

    更新日期:2019-06-18 00:00:00