Substance use disorder in hospitalized severely mentally ill psychiatric patients: prevalence, correlates, and subgroups.

abstract：BACKGROUND:Task-based functional neuroimaging studies of schizophrenia have not yet replicated the increased coordinated hyperactivity in speech-related brain regions that is reported with symptom-capture and resting-state studies of hallucinations. This may be due to suboptimal selection of cognitive tasks. METHODS:I...

journal_title：Schizophrenia bulletin

authors： Lavigne KM,Rapin LA,Metzak PD,Whitman JC,Jung K,Dohen M,Lœvenbruck H,Woodward TS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The at-risk mental state for psychosis (ARMS) and the first episode of psychosis have been associated with structural brain abnormalities that could aid in the individualized early recognition of psychosis. However, it is unknown whether the development of these brain alterations predates the clinical deteri...

journal_title：Schizophrenia bulletin

authors： Borgwardt S,Koutsouleris N,Aston J,Studerus E,Smieskova R,Riecher-Rössler A,Meisenzahl EM

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Schizophrenia leads to significant personal costs matched by high economic costs. Cognitive function is a strong predictor of disabilities in schizophrenia, which underpin these costs. This study of cognitive remediation therapy (CRT), which has been shown to improve cognition and reduce disability ...

journal_title：Schizophrenia bulletin

authors： Reeder C,Harris V,Pickles A,Patel A,Cella M,Wykes T

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:Cannabis use is associated with a younger age at onset of psychosis, an indicator of poor prognosis, but better cognitive function, a positive prognostic indicator. We aimed to clarify the role of age at onset and cognition on outcomes in cannabis users with first-episode schizophrenia as well as the effect o...

journal_title：Schizophrenia bulletin

authors： Leeson VC,Harrison I,Ron MA,Barnes TR,Joyce EM

更新日期：2012-06-01 00:00:00

abstract：:A substantial amount of research has focused on the midbrain dopamine system and its role in emotional and motivational behaviors. In diseases in which dopamine function is compromised, patients exhibit a constellation of symptoms, suggesting that the dopamine system plays an important role in the integration of sever...

journal_title：Schizophrenia bulletin

authors： Haber SN,Fudge JL

更新日期：1997-01-01 00:00:00

abstract：:Child maltreatment is a widespread public health problem associated with a range of mental health disorders later in life. In order to effectively address these disorders, there is a need to understand more about the mental health consequences of different types of child maltreatment. This study examines the associati...

journal_title：Schizophrenia bulletin

authors： Abajobir AA,Kisely S,Scott JG,Williams G,Clavarino A,Strathearn L,Najman JM

更新日期：2017-09-01 00:00:00

abstract：:While many who hear auditory hallucinations (AHs) experience them as unpleasant, some do not. Little is known about the correlates of AHs that are not unpleasant, or of the characteristics of those who hear them. To better understand this symptom, we used a comprehensive structured interview schedule to study 199 subj...

journal_title：Schizophrenia bulletin

authors： Copolov DL,Mackinnon A,Trauer T

更新日期：2004-01-01 00:00:00

abstract：:The relationship between a history of substance use disorder and the early course of psychotic illness was examined in 96 subjects with schizophrenia and 106 subjects with affective psychosis followed in the Suffolk County Mental Health Project, a longitudinal study of first-admission psychosis. Subjects received a st...

journal_title：Schizophrenia bulletin

authors： Kovasznay B,Fleischer J,Tanenberg-Karant M,Jandorf L,Miller AD,Bromet E

更新日期：1997-01-01 00:00:00

abstract：:Research into tardive dyskinesia, an involuntary movement disorder secondary to chronic neuroleptic treatment, has so far produced conflicting results with no clear clinical applications. Heterogeneous diagnostic criteria, research designs, and rating scales, plus an emphasis on single-drug trials, are probably respon...

journal_title：Schizophrenia bulletin

authors： Nasrallah HA

更新日期：1979-01-01 00:00:00

abstract：:It is increasingly evident that the brain is not truly an immune privileged site and that cells of the central nervous system are sensitive to the inflammation generated when the brain is fighting off infection. Among the many microorganisms that have access to the brain, the apicomplexan protozoan Toxoplasma gondii h...

journal_title：Schizophrenia bulletin

authors： Xiao J,Prandovszky E,Kannan G,Pletnikov MV,Dickerson F,Severance EG,Yolken RH

更新日期：2018-08-20 00:00:00

abstract：Objective:Evidence suggests that social skills training (SST) is an efficacious intervention for negative symptoms in psychosis, whereas evidence of efficacy in other psychosis symptom domains is limited. The current article reports a comprehensive meta-analytic review of the evidence for SST across relevant outcome me...

journal_title：Schizophrenia bulletin

authors： Turner DT,McGlanaghy E,Cuijpers P,van der Gaag M,Karyotaki E,MacBeth A

更新日期：2018-04-06 00:00:00

abstract：:A workshop on "Antipsychotics: Past and Future" was convened by the National Institute of Mental Health (NIMH), Division of Services and Intervention Research (DSIR), on July 14, 1998, to review the results of recent antipsychotic drug research, discuss current standards of treatment, and identify areas needing furthe...

journal_title：Schizophrenia bulletin

authors： Dawkins K,Lieberman JA,Lebowitz BD,Hsiao JK

更新日期：1999-01-01 00:00:00

abstract：:Recent advances in functional genomics have facilitated the identification of multiple genes and isoforms associated with the genetic risk of schizophrenia, yet the causal variations remain largely unclear. A previous study reported that the schizophrenia risk single-nucleotide polymorphism (SNP) rs7085104 at 10q24.32...

journal_title：Schizophrenia bulletin

authors： Cai X,Yang ZH,Li HJ,Xiao X,Li M,Chang H

更新日期：2021-01-23 00:00:00

abstract：:The nature and definition of schizotypy, as the latent liability for schizophrenia capable of generating various phenotypic and endophenotypic outcomes, is reviewed. The proceedings of the 2017 meeting of the International Consortium on Schizotypy Research are included in this Special Section and they are presented as...

journal_title：Schizophrenia bulletin

authors： Lenzenweger MF

更新日期：2018-10-15 00:00:00

abstract：:Given the rising costs of health care and the decrease in public expenditures on mental health care, policy-makers and program managers must identify cost-effective approaches for treating severely mentally ill patients. During the last year, there have been two major cost-effectiveness studies implemented in Californ...

journal_title：Schizophrenia bulletin

authors： Hu TW,Jerrell J

更新日期：1991-01-01 00:00:00

abstract：:Family interventions for first-episode psychosis (FEP) are an integral component of treatment, with positive effects mainly on patients' mental state and relapse rate. However, comparatively little attention has been paid to the effects of family interventions on caregivers' stress coping and well-being, especially in...

journal_title：Schizophrenia bulletin

authors： Chien WT,Thompson DR,Lubman DI,McCann TV

更新日期：2016-11-01 00:00:00

abstract：:Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, are common for patients with schizophrenia and might also be present in individuals ...

journal_title：Schizophrenia bulletin

authors： Lieslehto J,Kiviniemi VJ,Nordström T,Barnett JH,Murray GK,Jones PB,Paus T,Veijola J

更新日期：2019-06-18 00:00:00

abstract：:The search for a treatment of tardive dyskinesia (TD) has focused largely on cholinergic and GABAergic agents that are believed to attenuate striatal imbalances and bring about symptomatic control of dyskinetic movements. While numerous reports of the partial effectiveness of acute treatment with cholinergic or GABAer...

journal_title：Schizophrenia bulletin

authors： Kucharski LT,Unterwald EM

更新日期：1981-01-01 00:00:00

abstract：:The study of sexual dimorphism in brain morphology may help delineate subtypes of schizophrenia based, in part, on sex; yield insight into the relationship between brain structure and behavior; and provide a neurodevelopmental context for studying the ontogenesis of schizophrenia. Preliminary findings from an ongoing ...

journal_title：Schizophrenia bulletin

authors： Lewine RR,Gulley LR,Risch SC,Jewart R,Houpt JL

更新日期：1990-01-01 00:00:00

abstract：:Designs of clinical trials that will permit evaluation of independent, additive, and interactive effects of drugs and psychosocial treatments are described. The central feature of such designs is that they incorporate control conditions for both classes of treatment. Data from the articles in this issue are drawn upon...

journal_title：Schizophrenia bulletin

authors： Schooler NR

更新日期：1980-01-01 00:00:00

abstract：:Recently published data from the Roscommon Family Study show that a parental diagnosis of schizotypal disorder (SPD) has a significant and specific impact on the risk for schizophrenia in siblings of index probands with schizophrenia spectrum disorders. The distribution patterns of risks for schizophrenia and SPD in p...

journal_title：Schizophrenia bulletin

authors： Battaglia M,Bellodi L

更新日期：1996-01-01 00:00:00

abstract：:The present article reports findings on intelligence and personality functioning during the school period and at adolescence in a sample of kibbutz and urban Israeli children at risk for schizophrenia, as measured by a standard psychological test battery. On the first round of testing it was found that the index subje...

journal_title：Schizophrenia bulletin

authors： Sohlberg SC

更新日期：1985-01-01 00:00:00

abstract：:Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained attention in schizophrenia patients, although its neural mechanisms are unknown. Understanding the neural basis of this effect may lead to new treatment strategies for this cognitiv...

journal_title：Schizophrenia bulletin

authors： Hong LE,Schroeder M,Ross TJ,Buchholz B,Salmeron BJ,Wonodi I,Thaker GK,Stein EA

更新日期：2011-03-01 00:00:00

abstract：:This study compared the performance of 39 biological relatives of persons with schizophrenia to that of 30 normal adult controls on graphesthesia processing, a complex somatosensory processing task. The relatives performed significantly worse on the graphesthesia task compared to the healthy controls. The relatives an...

journal_title：Schizophrenia bulletin

authors： Chang BP,Lenzenweger MF

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Embodied emotions arise from interoceptive and somatosensory processes, and are essential to the development of a stable sense of self. Emotional embodiment is therefore inherently interwoven with our sense of bodily self-awareness, and allows us to navigate complex social situations. Given that the core feat...

journal_title：Schizophrenia bulletin

authors： Torregrossa LJ,Snodgress MA,Hong SJ,Nichols HS,Glerean E,Nummenmaa L,Park S

更新日期：2019-09-11 00:00:00

abstract：:Research on emotional processing in schizophrenia suggests relatively intact subjective responses to affective stimuli "in the moment." However, neuroimaging evidence suggests diminished activation in brain regions associated with emotional processing in schizophrenia. We asked whether given a more vulnerable cognitiv...

journal_title：Schizophrenia bulletin

authors： Becerril K,Barch D

更新日期：2011-09-01 00:00:00

abstract：:Secondary prevention in schizophrenia is still not good enough, and the authors of the articles in this issue of Schizophrenia Bulletin present important new knowledge that may increase earlier detection and treatment. This final article discusses some of their main findings in relation to clinical consequences and ne...

journal_title：Schizophrenia bulletin

authors： Vaglum P

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Acute treatment with subanaesthetic doses of NMDA receptor antagonists, such as ketamine, provides a translational model with relevance to many of the symptoms of schizophrenia. Previous studies have focused specifically on the prefrontal cortex (PFC) because this region is implicated in many of the function...

journal_title：Schizophrenia bulletin

authors： Dawson N,Morris BJ,Pratt JA

更新日期：2013-03-01 00:00:00

abstract：:The two indices that have been proposed for quantifying the accuracy of smooth-following eye movements are shown to be interchangeable. This algebraic fact will permit comparability of values between laboratories only if workers who employ the signal-to-noise ratio (S/N) as their index measure S and N as the total sig...

journal_title：Schizophrenia bulletin

authors： Lykken DT,Iacono WG,Lykken JD

更新日期：1981-01-01 00:00:00

abstract：INTRODUCTION:Auditory hallucinations are a hallmark symptom of schizophrenia. The neural basis of auditory hallucinations was examined using data from a working memory task. Data were acquired within a multisite consortium and this unique dataset provided the opportunity to analyze data from a large number of subjects ...

journal_title：Schizophrenia bulletin

authors： Wible CG,Lee K,Molina I,Hashimoto R,Preus AP,Roach BJ,Ford JM,Mathalon DH,McCarthey G,Turner JA,Potkin SG,O'Leary D,Belger A,Diaz M,Voyvodic J,Brown GG,Notestine R,Greve D,Lauriello J,FBIRN.

更新日期：2009-01-01 00:00:00