Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood.


:Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, are common for patients with schizophrenia and might also be present in individuals at risk of developing schizophrenia. Here we explore whether an individual's polygenic risk score (PRS) for schizophrenia is associated with the degree of interregional similarities in blood oxygen level-dependent (BOLD) signal and gray matter volume of the face-processing network and whether the exposure to early adversity moderates this association. A total of 90 individuals (mean age 22 years, both functional and structural data available) were used for discovery analyses, and 211 individuals (mean age 26 years, structural data available) were used for replication of the structural findings. Both samples were drawn from the Northern Finland Birth Cohort 1986. We found that the degree of interregional similarities in BOLD signal and gray matter volume vary as a function of PRS; lowest interregional correlation (both measures) was observed in individuals with high PRS. We also replicated the gray matter volume finding. We did not find evidence for an interaction between early adversity and PRS on the interregional correlation of BOLD signal and gray matter volume. We speculate that the observed group differences in PRS-related correlations in both modalities may result from differences in the concurrent functional engagement of the face-processing regions over time, eg, via differences in exposure to social interaction with other people.


Schizophr Bull


Schizophrenia bulletin


Lieslehto J,Kiviniemi VJ,Nordström T,Barnett JH,Murray GK,Jones PB,Paus T,Veijola J




Has Abstract


2019-06-18 00:00:00














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    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Stopper CM,Floresco SB

    更新日期:2015-01-01 00:00:00

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    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Siever LJ

    更新日期:1985-01-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2006-04-01 00:00:00

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    pub_type: 杂志文章,评审


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    更新日期:1997-01-01 00:00:00

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    更新日期:2020-01-04 00:00:00

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    journal_title:Schizophrenia bulletin



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    更新日期:2013-11-01 00:00:00

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    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Sellen JL,Oaksford M,Gray NS

    更新日期:2005-01-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: McGlashan TH

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    pub_type: 杂志文章,评审


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    更新日期:2009-03-01 00:00:00

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    更新日期:2018-08-20 00:00:00

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    pub_type: 杂志文章


    authors: Holsenbeck LS 3rd,Davidson LM,Hostetter RE,Casanova MF,Taylor DO,Kelley CT,Perrotta C Jr,Borison RL,Diamond B

    更新日期:1992-01-01 00:00:00

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    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


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    更新日期:2004-01-01 00:00:00

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    authors: Kim M,Hwang WJ,Park J,Kim T,Oh S,Kwon JS

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    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Haig GM,Bain E,Robieson W,Othman AA,Baker J,Lenz RA

    更新日期:2014-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Isvoranu AM,van Borkulo CD,Boyette LL,Wigman JT,Vinkers CH,Borsboom D,Group Investigators.

    更新日期:2017-01-01 00:00:00

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    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Horton HK,Silverstein SM

    更新日期:2011-07-01 00:00:00

  • Schizophrenia with onset in adolescence: an 11-year followup.

    abstract::This study examined the course of illness and factors affecting it in schizophrenias with onset between the ages of 14 and 18. Noteworthy in comparison to findings from other followup studies is the higher proportion of chronic courses of illness, about 50 percent. In addition, the type of course of illness correspond...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Krausz M,Müller-Thomsen T

    更新日期:1993-01-01 00:00:00

  • NMDA receptor and schizophrenia: a brief history.

    abstract::Although glutamate was first hypothesized to be involved in the pathophysiology of schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) receptor antagonists, the dissociative anesthetics, could replicate the full range of psychotic, negative, cognitive, and physiologic features of schi...

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    pub_type: 历史文章,杂志文章


    authors: Coyle JT

    更新日期:2012-09-01 00:00:00

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    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Csernansky JG,Holman CA,Hollister LE

    更新日期:1983-01-01 00:00:00

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    abstract::Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and intracranial volume (ICV). However, little is known about the underlying etiology of these brain alterations. Here, we explored whether brain structure volumes and SCZ share genetic risk factors. Using conditional false discovery rate ...

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    pub_type: 杂志文章


    authors: Smeland OB,Wang Y,Frei O,Li W,Hibar DP,Franke B,Bettella F,Witoelar A,Djurovic S,Chen CH,Thompson PM,Dale AM,Andreassen OA

    更新日期:2018-06-06 00:00:00

  • Personality and neuropsychological performance of high-risk children.

    abstract::The present article reports findings on intelligence and personality functioning during the school period and at adolescence in a sample of kibbutz and urban Israeli children at risk for schizophrenia, as measured by a standard psychological test battery. On the first round of testing it was found that the index subje...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Sohlberg SC

    更新日期:1985-01-01 00:00:00

  • A meta-analysis of mentalizing impairments in adults with schizophrenia and autism spectrum disorder.

    abstract::Mentalizing has been examined both in autism spectrum disorder (ASD) and schizophrenia (SCZ) primarily by either cognitive-linguistic (referred to as verbal) or emotion recognition from eyes (referred to as visual) mentalizing tasks. Each type of task is thought to measure different aspects of mentalizing. Differences...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,meta分析


    authors: Chung YS,Barch D,Strube M

    更新日期:2014-05-01 00:00:00

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    abstract::As a result of improving technologies and greatly increased sample sizes, the last 2 years has seen unprecedented advances in identification of specific genetic risk factors for psychiatric phenotypes. Strong genetic associations have been reported at common polymorphisms within ANK3 and CACNA1C in bipolar disorder an...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Craddock N,O'Donovan MC,Owen MJ

    更新日期:2009-05-01 00:00:00

  • Pathways to aggression in schizophrenia affect results of treatment.

    abstract::Schizophrenia elevates the risk for aggressive behavior and violent crime, and different approaches have been used to manage this problem. The results of such treatments vary. One reason for this variation is that aggressive behavior in schizophrenia is heterogeneous in origin. This heterogeneity has usually not been ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审


    authors: Volavka J,Citrome L

    更新日期:2011-09-01 00:00:00

  • The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?

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    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,评审


    authors: Abou Jamra R,Schmael C,Cichon S,Rietschel M,Schumacher J,Nöthen MM

    更新日期:2006-10-01 00:00:00

  • Clinical, functional, and economic ramifications of early nonresponse to antipsychotics in the naturalistic treatment of schizophrenia.

    abstract:OBJECTIVE:Early nonresponse to antipsychotics appears to predict subsequent nonresponse to treatment when assessed in randomized controlled trials of predominately acute inpatients treated for schizophrenia. This study assessed the predictive accuracy of early nonresponse to treatment and its clinical, functional, and ...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ascher-Svanum H,Nyhuis AW,Faries DE,Kinon BJ,Baker RW,Shekhar A

    更新日期:2008-11-01 00:00:00

  • Hippocampal Shape Abnormalities Predict Symptom Progression in Neuroleptic-Free Youth at Ultrahigh Risk for Psychosis.

    abstract:INTRODUCTION:Hippocampal abnormalities have been widely studied in schizophrenia spectrum populations including those at ultrahigh risk (UHR) for psychosis. There have been inconsistent findings concerning hippocampal morphology prior to and during the transition to psychosis, and little is known about how specific sub...

    journal_title:Schizophrenia bulletin

    pub_type: 杂志文章


    authors: Dean DJ,Orr JM,Bernard JA,Gupta T,Pelletier-Baldelli A,Carol EE,Mittal VA

    更新日期:2016-01-01 00:00:00