Diurnal weight gain in chronic psychosis.

Abstract:

:We found diurnal weight gain to be abnormal among 93 chronically psychotic patients, most of whom had schizophrenia. They were weighed at 7 a.m. and 4 p.m. weekly for 3 weeks. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and dividing the result by the 7 a.m. weight. NDWG was 1.7 +/- 1.0 percent for the study sample, 0.6 +/- 0.4 percent for 16 acutely psychotic controls, and 0.5 +/- 0.4 percent for 29 normals. More than 60 percent of the study sample had abnormal NDWG values. NDWG related to antipsychotic drug dose (r = 0.290, p = 0.005) with variability in drug dose accounting for 8 percent of the variability in NDWG. This report provides yet another piece of evidence that disordered water balance is common in chronic psychiatric patients. The etiology is unknown, but it may relate to subtle brain abnormalities in the regulation of fluid intake and excretion.

journal_name

Schizophr Bull

journal_title

Schizophrenia bulletin

authors

Vieweg WV,Godleski LS,Graham P,Kellogg EJ,Goldman F,Barber J,Bayliss EV,Glick JL,Hundley PL,Yank GR

doi

10.1093/schbul/15.3.501

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

501-6

issue

3

eissn

0586-7614

issn

1745-1701

journal_volume

15

pub_type

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