Synapse Pathology in Schizophrenia: A Meta-analysis of Postsynaptic Elements in Postmortem Brain Studies.

abstract：:Schizophrenia (SZ) is a devastating mental disease caused by complex genetic and environmental factors. The pathological process and clinical manifestation of SZ are heterogeneous among patients, which hampers precise diagnosis and treatment of the disease. Since no objective marker for SZ has been established today, ...

journal_title：Schizophrenia bulletin

authors： Sun L,Yang X,Jiang J,Hu X,Qing Y,Wang D,Yang T,Yang C,Zhang J,Yang P,Wang P,Cai C,Wang J,He L,Wan C

更新日期：2018-06-06 00:00:00

abstract：:This article focuses on the schizophrenic disorganization syndrome, which was initially described by Bleuler (who used the term "dissociation") as lying at the heart of schizophrenia. While adopting a neo-Bleulerian approach, we describe schizophrenic disorganization using a pathogenetic hypothesis and a three-part st...

journal_title：Schizophrenia bulletin

authors： Hardy-Baylé MC,Sarfati Y,Passerieux C

更新日期：2003-01-01 00:00:00

abstract：:Mentalizing has been examined both in autism spectrum disorder (ASD) and schizophrenia (SCZ) primarily by either cognitive-linguistic (referred to as verbal) or emotion recognition from eyes (referred to as visual) mentalizing tasks. Each type of task is thought to measure different aspects of mentalizing. Differences...

journal_title：Schizophrenia bulletin

authors： Chung YS,Barch D,Strube M

更新日期：2014-05-01 00:00:00

abstract：:This article examines the factors that influence antipsychotic use among youth treated in public inpatient facilities. By combining data from 11 focus groups, a survey of 43 researchers and clinicians, and a chart review of 100 closed patient charts, we investigated the interplay between physicians' and staff members'...

journal_title：Schizophrenia bulletin

authors： Pappadopulos E,Jensen PS,Schur SB,MacIntyre JC 2nd,Ketner S,Van Orden K,Sverd J,Sardana S,Woodlock D,Schweitzer R,Rube D

更新日期：2002-01-01 00:00:00

abstract：:Social networks of 35 mentally ill persons were studied in Lao villages. Mental illness was associated with a decrease in size of social networks, disproportionate reliance on family, and asymmetric instrumental exchange. Nonkin "sponsors" provided assistance to those alienated from or abandoned by relatives. For thos...

journal_title：Schizophrenia bulletin

authors： Westermeyer J,Pattison EM

更新日期：1981-01-01 00:00:00

abstract：:Cognitive deficits are a central and debilitating aspect of schizophrenia and other major mental illnesses. Although they are largely refractory to pharmacotherapy, multiple studies have now shown that large and lasting improvements in cognition can result from behavioral interventions. We will review our work over th...

journal_title：Schizophrenia bulletin

authors： Wexler BE,Bell MD

更新日期：2005-10-01 00:00:00

abstract：:Families of study children were interviewed, with a focus on parents' observations of the personality and behavior of their offspring. The family interview was also the primary source of information about the home environment and possible psychopathology in nonschizophrenic parents. By parental report, index children ...

journal_title：Schizophrenia bulletin

authors： Shotten JH

更新日期：1985-01-01 00:00:00

abstract：:Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...

journal_title：Schizophrenia bulletin

authors： Gong Q,Dazzan P,Scarpazza C,Kasai K,Hu X,Marques TR,Iwashiro N,Huang X,Murray RM,Koike S,David AS,Yamasue H,Lui S,Mechelli A

更新日期：2015-11-01 00:00:00

abstract：:A greater understanding of the links between cognitive and social functioning changes is needed to refine cognitive treatments for schizophrenia. To date, studies have been cross-sectional, and few have investigated the impact of cognitive change. This single-blind randomized controlled trial explored the links betwee...

journal_title：Schizophrenia bulletin

authors： Reeder C,Smedley N,Butt K,Bogner D,Wykes T

更新日期：2006-10-01 00:00:00

abstract：:One of the leading theories of the neuropathology of schizophrenia is that it is a developmental disorder of "neural connectivity." To assess this theory, it is first necessary to understand how precise neural connections normally are established. Sensory-driven neural activity has been widely recognized as crucial fo...

journal_title：Schizophrenia bulletin

authors： Penn AA

更新日期：2001-01-01 00:00:00

abstract：:Studies indicate a high prevalence of childhood trauma in patient cohorts with established psychotic disorder and in those at risk of developing psychosis. A causal link between childhood trauma and development of psychosis has been proposed. We aimed to examine the association between experience of childhood trauma a...

journal_title：Schizophrenia bulletin

authors： Thompson AD,Nelson B,Yuen HP,Lin A,Amminger GP,McGorry PD,Wood SJ,Yung AR

更新日期：2014-05-01 00:00:00

abstract：:Distinguishing between brain-damaged and schizophrenic patients remains a significant clinical problem. However, substantive and methodological difficulties have led to discouragement and consequent loss of interest in this area of differential diagnosis. Several models for making this distinction were proposed: cogni...

journal_title：Schizophrenia bulletin

authors： Goldstein G

更新日期：1978-01-01 00:00:00

abstract：:Recent advances in functional genomics have facilitated the identification of multiple genes and isoforms associated with the genetic risk of schizophrenia, yet the causal variations remain largely unclear. A previous study reported that the schizophrenia risk single-nucleotide polymorphism (SNP) rs7085104 at 10q24.32...

journal_title：Schizophrenia bulletin

authors： Cai X,Yang ZH,Li HJ,Xiao X,Li M,Chang H

更新日期：2021-01-23 00:00:00

abstract：:Increased critical stimulus duration among nonpsychotic subjects with Minnesota Multiphasic Personality Inventory 2-7-8 profiles in the Merritt and Balogh letter-discrimination procedure is consistent with the view that this abnormality might be a vulnerability indicator for a poor prognosis, chronic type of schizophr...

journal_title：Schizophrenia bulletin

authors： Nuechterlein KH,Dawson ME

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Cannabis use has been identified as a potent predictor of the earlier onset of psychosis, but meta-analysis has not indicated that it has a clear effect in established psychosis. AIM:To assess the association between cannabis and outcomes, including whether change in cannabis use affects symptoms and functi...

journal_title：Schizophrenia bulletin

authors： Barrowclough C,Emsley R,Eisner E,Beardmore R,Wykes T

更新日期：2013-03-01 00:00:00

abstract：UNLABELLED:We aimed to discover whether metabolic complications of schizophrenia (SZ) are present in first episode (FE) and unmedicated (UM) patients, in comparison with patients established on antipsychotic medication (AP). METHOD:A systematic search, critical appraisal, and meta-analysis were conducted of studies to...

journal_title：Schizophrenia bulletin

authors： Mitchell AJ,Vancampfort D,De Herdt A,Yu W,De Hert M

更新日期：2013-03-01 00:00:00

abstract：:Thalamus abnormalities are common in neurological and psychiatric illnesses. Therefore, it is essential to understand the properties of the thalamus-related networks. The thalamic reticular nucleus (TRN) is a thin GABAergic layer interface strategically located between the thalamus and the neocortex. It is, at the ver...

journal_title：Schizophrenia bulletin

authors： Pinault D

更新日期：2011-03-01 00:00:00

abstract：:This article focuses on the cross-modal reaction time paradigm, which has been used to study deviation patterns of shifting attention across stimulus modalities in schizophrenic patients. Cross-modal reaction time research involving pathological and nonpathological populations is reviewed. The influence of sex, stimul...

journal_title：Schizophrenia bulletin

authors： Mannuzza S

更新日期：1980-01-01 00:00:00

abstract：:Impaired attention is commonly observed among schizophrenia patients and those at genetic risk for the disease. This article reviews over 40 studies that used various versions of the Continuous Performance Test (CPT) as the primary measure of attention. These studies of normal subjects, affected patients, and various ...

journal_title：Schizophrenia bulletin

authors： Cornblatt BA,Keilp JG

更新日期：1994-01-01 00:00:00

abstract：:One of the main questions related to schizophrenia is, naturally enough, what is it? Such a question may seem obvious, naive, impossible, or any combination of these. And certainly it is a bit demanding to expect that anyone could say what schizophrenia is in 1,000 words. On the other hand, we felt that it was worth t...

journal_title：Schizophrenia bulletin

authors： Meltzer HY,Liberman RP

更新日期：1982-01-01 00:00:00

abstract：:Research on emotional processing in schizophrenia suggests relatively intact subjective responses to affective stimuli "in the moment." However, neuroimaging evidence suggests diminished activation in brain regions associated with emotional processing in schizophrenia. We asked whether given a more vulnerable cognitiv...

journal_title：Schizophrenia bulletin

authors： Becerril K,Barch D

更新日期：2011-09-01 00:00:00

abstract：:In response to my discussion of sex differences in concordance rates for schizophrenia in twins, Lewine (1979) noted that male schizophrenics are hospitalized earlier than females. He questioned whether females had been followed through the risk period. To clarify, I calculated the age at followup of discordant twins ...

journal_title：Schizophrenia bulletin

authors： Samuels L

更新日期：1979-01-01 00:00:00

abstract：:Despite NIMH efforts to facilitate the study of women and minorities in federally funded schizophrenia research, there is a significant lack of information about race differences in brain morphology and neuropsychological function in schizophrenia. A review of three major psychiatric journals between 1994 and 1996 rev...

journal_title：Schizophrenia bulletin

authors： Lewine RR,Caudle J

更新日期：1999-01-01 00:00:00

abstract：:Spatial working memory (WM) processing has 3 distinct phases: encoding, maintenance, and retrieval and its dysfunction is a core feature in schizophrenia. We examined phase-specific brain activations associated with spatial WM in first-degree relatives of schizophrenia (genetic high risk, GHR), ultra-high risk (UHR) s...

journal_title：Schizophrenia bulletin

authors： Choi JS,Park JY,Jung MH,Jang JH,Kang DH,Jung WH,Han JY,Choi CH,Hong KS,Kwon JS

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this study was (1) to identify the demographic and psychosocial characteristics of Korean-Americans with schizophrenia, and (2) to compare the demographic and psychosocial characteristics of Korean-Americans with schizophrenia to African-American, Latino, and Euro-American individuals with schizophrenia...

journal_title：Schizophrenia bulletin

authors： Bae SW,Brekke JS

更新日期：2002-01-01 00:00:00

abstract：:Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-related weight gain is missing. In this review, random effects meta-analyses were conducted for dominant and recessive models on association...

journal_title：Schizophrenia bulletin

authors： Zhang JP,Lencz T,Zhang RX,Nitta M,Maayan L,John M,Robinson DG,Fleischhacker WW,Kahn RS,Ophoff RA,Kane JM,Malhotra AK,Correll CU

更新日期：2016-11-01 00:00:00

abstract：:This meta-analytic review sought to answer questions concerning the role of psychosocial treatments in the comprehensive management of patients with schizophrenia. The review focused on the effects of combining psychosocial treatment with somatic treatment. Findings demonstrated the additive and supplementary effects ...

journal_title：Schizophrenia bulletin

authors： Mojtabai R,Nicholson RA,Carpenter BN

更新日期：1998-01-01 00:00:00

abstract：:The role of negative cognition and effect in maintaining psychotic symptoms is increasingly recognized but has yet to be substantiated though longitudinal analysis. Based on an a priori theoretical model, we hypothesized that negative cognition and depressed mood play a direct causal role in maintaining paranoia in pe...

journal_title：Schizophrenia bulletin

authors： Fowler D,Hodgekins J,Garety P,Freeman D,Kuipers E,Dunn G,Smith B,Bebbington PE

更新日期：2012-09-01 00:00:00

abstract：:This study compared the performance of 39 biological relatives of persons with schizophrenia to that of 30 normal adult controls on graphesthesia processing, a complex somatosensory processing task. The relatives performed significantly worse on the graphesthesia task compared to the healthy controls. The relatives an...

journal_title：Schizophrenia bulletin

authors： Chang BP,Lenzenweger MF

更新日期：2004-01-01 00:00:00

abstract：:Childhood trauma (CT) has been identified as a potential risk factor for the onset of psychotic disorders. However, to date, there is limited consensus with respect to which symptoms may ensue after exposure to trauma in early life, and whether specific pathways may account for these associations. The aim of the prese...

journal_title：Schizophrenia bulletin

authors： Isvoranu AM,van Borkulo CD,Boyette LL,Wigman JT,Vinkers CH,Borsboom D,Group Investigators.

更新日期：2017-01-01 00:00:00