Dysfunctional thalamus-related networks in schizophrenia.

abstract：:Phenotypic heterogeneity within patients and controls may explain why the genetic variants contributing to schizophrenia risk explain only a fraction of the heritability. The aim of this study is to investigate quantitative and qualitative differences in psychosis symptoms in a sample including psychosis patients, the...

journal_title：Schizophrenia bulletin

authors： Derks EM,Allardyce J,Boks MP,Vermunt JK,Hijman R,Ophoff RA,GROUP.

更新日期：2012-05-01 00:00:00

abstract：:The role of negative cognition and effect in maintaining psychotic symptoms is increasingly recognized but has yet to be substantiated though longitudinal analysis. Based on an a priori theoretical model, we hypothesized that negative cognition and depressed mood play a direct causal role in maintaining paranoia in pe...

journal_title：Schizophrenia bulletin

authors： Fowler D,Hodgekins J,Garety P,Freeman D,Kuipers E,Dunn G,Smith B,Bebbington PE

更新日期：2012-09-01 00:00:00

abstract：:We examined neurocognitive correlates of three dimensions of schizotypy in 63 healthy first degree relatives of schizophrenia patients. Neurocognitive measures of attention, verbal memory, and prefrontal functioning were combined with self-report and interview measures of schizotypy. State-psychopathology (anxiety and...

journal_title：Schizophrenia bulletin

authors： Vollema MG,Postma B

更新日期：2002-01-01 00:00:00

abstract：:Although the various manifestations of disordered thought have played a central role in diagnostic and theoretical considerations of schizophrenia, such symptoms have not been found specific to schizophrenia, and at best have shown weak relations to outcome. As part of a 7-year followup study of a sample of young, acu...

journal_title：Schizophrenia bulletin

authors： Knight RA,Elliott DS,Roff JD,Watson CG

更新日期：1986-01-01 00:00:00

abstract：:Secondary prevention in schizophrenia is still not good enough, and the authors of the articles in this issue of Schizophrenia Bulletin present important new knowledge that may increase earlier detection and treatment. This final article discusses some of their main findings in relation to clinical consequences and ne...

journal_title：Schizophrenia bulletin

authors： Vaglum P

更新日期：1996-01-01 00:00:00

abstract：:This article focuses on the schizophrenic disorganization syndrome, which was initially described by Bleuler (who used the term "dissociation") as lying at the heart of schizophrenia. While adopting a neo-Bleulerian approach, we describe schizophrenic disorganization using a pathogenetic hypothesis and a three-part st...

journal_title：Schizophrenia bulletin

authors： Hardy-Baylé MC,Sarfati Y,Passerieux C

更新日期：2003-01-01 00:00:00

abstract：:Deluded people differ from nondeluded controls on attributional style questionnaires and probabilistic-reasoning and theory-of-mind (ToM) tasks. No study to date has examined the relations between these 3 reasoning anomalies in the same individuals so as to evaluate their functional independence and potentially inform...

journal_title：Schizophrenia bulletin

authors： Langdon R,Ward PB,Coltheart M

更新日期：2010-03-01 00:00:00

abstract：:Although weight gain is a serious but variable adverse effect of antipsychotics that has genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of antipsychotic-related weight gain is missing. In this review, random effects meta-analyses were conducted for dominant and recessive models on association...

journal_title：Schizophrenia bulletin

authors： Zhang JP,Lencz T,Zhang RX,Nitta M,Maayan L,John M,Robinson DG,Fleischhacker WW,Kahn RS,Ophoff RA,Kane JM,Malhotra AK,Correll CU

更新日期：2016-11-01 00:00:00

abstract：:Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric dise...

journal_title：Schizophrenia bulletin

authors： Chou IJ,Kuo CF,Huang YS,Grainge MJ,Valdes AM,See LC,Yu KH,Luo SF,Huang LS,Tseng WY,Zhang W,Doherty M

更新日期：2017-09-01 00:00:00

abstract：:Cognitive disruption in schizophrenia is associated with altered patterns of spatiotemporal interaction associated with multiple electroencephalogram (EEG) frequency bands in cortex. In particular, changes in the generation of gamma (30-80 Hz) and beta2 (20-29 Hz) rhythms correlate with observed deficits in communicat...

journal_title：Schizophrenia bulletin

authors： Roopun AK,Cunningham MO,Racca C,Alter K,Traub RD,Whittington MA

更新日期：2008-09-01 00:00:00

abstract：:Kraepelin said severe mental illness was due to 2 diseases subsequently characterized as disorders of thought vs disorders of mood, ie, the Kraepelinian dichotomy. Schizophrenia, traditionally considered the disorder of thought, has been defined by the presence of hallucinations, delusions, catatonia, and disorganizat...

journal_title：Schizophrenia bulletin

authors： Raymond Lake C

更新日期：2008-01-01 00:00:00

abstract：:A workshop on "Antipsychotics: Past and Future" was convened by the National Institute of Mental Health (NIMH), Division of Services and Intervention Research (DSIR), on July 14, 1998, to review the results of recent antipsychotic drug research, discuss current standards of treatment, and identify areas needing furthe...

journal_title：Schizophrenia bulletin

authors： Dawkins K,Lieberman JA,Lebowitz BD,Hsiao JK

更新日期：1999-01-01 00:00:00

abstract：:Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Re...

journal_title：Schizophrenia bulletin

authors： Gong Q,Dazzan P,Scarpazza C,Kasai K,Hu X,Marques TR,Iwashiro N,Huang X,Murray RM,Koike S,David AS,Yamasue H,Lui S,Mechelli A

更新日期：2015-11-01 00:00:00

abstract：:Negative symptoms of schizophrenia remain an area of substantial unmet clinical need. By convening a consensus conference in January 2005, the NIMH has taken a leading role in stimulating a resurgence of interest in methodological considerations related to development of new medications for treating negative symptoms....

journal_title：Schizophrenia bulletin

authors： Alphs L

更新日期：2006-04-01 00:00:00

abstract：:Cognitive impairment associated with schizophrenia (CIAS) includes neuropsychological deficits in attention, working memory, verbal learning, and problem solving. These deficits have been shown to be linked to impairment in functional status (eg, social behavior, work performance, and activities of daily living) among...

journal_title：Schizophrenia bulletin

authors： Matza LS,Buchanan R,Purdon S,Brewster-Jordan J,Zhao Y,Revicki DA

更新日期：2006-10-01 00:00:00

abstract：:As a result of improving technologies and greatly increased sample sizes, the last 2 years has seen unprecedented advances in identification of specific genetic risk factors for psychiatric phenotypes. Strong genetic associations have been reported at common polymorphisms within ANK3 and CACNA1C in bipolar disorder an...

journal_title：Schizophrenia bulletin

authors： Craddock N,O'Donovan MC,Owen MJ

更新日期：2009-05-01 00:00:00

abstract：:Sustained attention abnormality in schizophrenia is usually refractory to available treatment. Nicotine can transiently improve sustained attention in schizophrenia patients, although its neural mechanisms are unknown. Understanding the neural basis of this effect may lead to new treatment strategies for this cognitiv...

journal_title：Schizophrenia bulletin

authors： Hong LE,Schroeder M,Ross TJ,Buchholz B,Salmeron BJ,Wonodi I,Thaker GK,Stein EA

更新日期：2011-03-01 00:00:00

abstract：:The present functional magnetic resonance imaging study investigated the neural correlates of practice-associated activation changes in patients with schizophrenia and their association with symptom severity. A group of patients (n = 24) were divided into more successful and less successful learners and were asked to ...

journal_title：Schizophrenia bulletin

authors： Koch K,Wagner G,Schachtzabel C,Schultz C,Sauer H,Schlösser RG

更新日期：2010-05-01 00:00:00

abstract：:The association between low birth weight and schizophrenia has been suggested by many studies. Small for gestational age (SGA) is a measure used as a proxy for intrauterine growth restriction. We aim to examine if children who are born SGA are at increased risk of developing schizophrenia and whether an association ma...

journal_title：Schizophrenia bulletin

authors： Nielsen PR,Mortensen PB,Dalman C,Henriksen TB,Pedersen MG,Pedersen CB,Agerbo E

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:In light of the evidence for brain white matter (WM) abnormalities in schizophrenia, study of normal WM maturation in adolescence may provide critical insights relevant to the neurodevelopment of the disorder. Voxel-wise diffusion tensor imaging (DTI) studies have consistently demonstrated increases in fract...

journal_title：Schizophrenia bulletin

authors： Peters BD,Szeszko PR,Radua J,Ikuta T,Gruner P,DeRosse P,Zhang JP,Giorgio A,Qiu D,Tapert SF,Brauer J,Asato MR,Khong PL,James AC,Gallego JA,Malhotra AK

更新日期：2012-11-01 00:00:00

abstract：:Motor abnormalities in schizophrenia spectrum disorders (SSD) have increasingly attracted scientific interest in the past years. However, the neural mechanisms underlying parkinsonism in SSD are unclear. The present multimodal magnetic resonance imaging (MRI) study examined SSD patients with and without parkinsonism, ...

journal_title：Schizophrenia bulletin

authors： Wolf RC,Rashidi M,Fritze S,Kubera KM,Northoff G,Sambataro F,Calhoun VD,Geiger LS,Tost H,Hirjak D

更新日期：2020-07-08 00:00:00

abstract：:The evidence suggesting that genetic factors are involved in the etiology of schizophrenia is reviewed. Despite methodological and other difficulties, independent lines of research--family, twin, and adoption studies--point in a common direction: Persons genetically at risk for schizophrenia are more likely to become ...

journal_title：Schizophrenia bulletin

authors： Kessler S

更新日期：1980-01-01 00:00:00

abstract：:Numerous studies have differentiated schizophrenic patients and normal controls in electroencephalography (EEG) spectral patterns recorded at rest. We replicated the resting EEG spectral differences between these groups and observed significant differences in periodic photic stimuli on the EEG spectra. Drug-free schiz...

journal_title：Schizophrenia bulletin

authors： Jin Y,Potkin SG,Rice D,Sramek J,Costa J,Isenhart R,Heh C,Sandman CA

更新日期：1990-01-01 00:00:00

abstract：:The dopamine hypothesis of schizophrenia implies that alterations in the dopamine system cause functional abnormalities in the brain that may converge to aberrant salience attribution and eventually lead to psychosis. Indeed, widespread brain disconnectivity across the psychotic spectrum has been revealed by resting-s...

journal_title：Schizophrenia bulletin

authors： Rössler J,Unterassner L,Wyss T,Haker H,Brugger P,Rössler W,Wotruba D

更新日期：2019-04-25 00:00:00

abstract：:Pharmacologic agents currently used or being studied for the treatment of schizophrenia are reviewed. Neuroleptic medications are still the mainstay of treatment, but recent studies suggest new approaches to dosage and to the treatment of acute psychosis. Lithium is beneficial in psychotic illnesses with acute onset a...

journal_title：Schizophrenia bulletin

authors： Donaldson SR,Gelenberg AJ,Baldessarini RJ

更新日期：1983-01-01 00:00:00

abstract：:This study investigated the role of reasoning biases in delusion formation and maintenance. Reasoning judgments have been shown to be influenced by prior knowledge, beliefs, and experience--that is, information stored in semantic memory. It was hypothesized that high schizotypes would exhibit a "jump to conclusions" s...

journal_title：Schizophrenia bulletin

authors： Sellen JL,Oaksford M,Gray NS

更新日期：2005-01-01 00:00:00

abstract：:The aim of the study was to evaluate the latent structure of DSM-IV schizotypal personality disorder (SPD) diagnostic criteria. The sample consisted of 564 consecutively admitted inpatients and outpatients. Exploratory latent class analysis identified a four-class model as the best fitting model for DSM-IV SPD criteri...

journal_title：Schizophrenia bulletin

authors： Fossati A,Maffei C,Battaglia M,Bagnato M,Donati D,Donini M,Fiorilli M,Novella L

更新日期：2001-01-01 00:00:00

abstract：:Staff members from nine mental health agencies were trained in psychiatric rehabilitation technology. The trainers then received intensive followup to assist them in implementing the technology in their own agencies. Evaluation of the impact of the "training of trainers" strategy suggested that mental health workers w...

journal_title：Schizophrenia bulletin

authors： Rogers ES,Cohen BF,Danley KS,Hutchinson D,Anthony WA

更新日期：1986-01-01 00:00:00

abstract：:Descriptions of various psychotic symptoms in children began to appear in the psychiatric literature at about the same time as descriptions of psychotic symptoms in adults. For example, Kraepelin estimated that at least 3.5 percent of his cases of dementia praecox had onsets before age 10. The construct of "childhood ...

journal_title：Schizophrenia bulletin

authors： Asarnow RF,Asarnow JR

更新日期：1994-01-01 00:00:00

abstract：:We reported previously that residents of Greater Helsinki, Finland, whose mothers were exposed to the 1957 influenza epidemic during their second trimester of gestation had a significantly elevated risk of developing adult schizophrenia. The majority of the replication studies to date have not determined whether the m...

journal_title：Schizophrenia bulletin

authors： Mednick SA,Huttunen MO,Machón RA

更新日期：1994-01-01 00:00:00