18F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation.

abstract：:A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of ...

journal_title：Scientific reports

authors： Ottosson H,Nylén F,Sarker P,Miraglia E,Bergman P,Gudmundsson GH,Raqib R,Agerberth B,Strömberg R

更新日期：2016-11-09 00:00:00

abstract：:Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...

journal_title：Scientific reports

authors： Senyshyn A,Mühlbauer MJ,Dolotko O,Hofmann M,Ehrenberg H

更新日期：2015-12-18 00:00:00

abstract：:Exploiting pattern formation - such as that observed in nature - in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on e...

journal_title：Scientific reports

authors： Seghir R,Arscott S

更新日期：2015-10-06 00:00:00

abstract：:Flow of non-Newtonian fluids through topologically complex structures is ubiquitous in most biological, industrial and environmental settings. The interplay between local hydrodynamics and the fluid's constitutive law determines the distribution of flow paths. Consequently the spatial heterogeneity of the viscous resi...

journal_title：Scientific reports

authors： Eberhard U,Seybold HJ,Secchi E,Jiménez-Martínez J,Rühs PA,Ofner A,Andrade JS Jr,Holzner M

更新日期：2020-07-16 00:00:00

abstract：:One of the most important goals of condensed matter physics is materials by design, i.e. the ability to reliably predict and design materials with a set of desired properties. A striking example is the deterministic enhancement of the superconducting properties of materials. Recent experiments have demonstrated that t...

journal_title：Scientific reports

authors： Smolyaninova VN,Jensen C,Zimmerman W,Prestigiacomo JC,Osofsky MS,Kim H,Bassim N,Xing Z,Qazilbash MM,Smolyaninov II

更新日期：2016-09-23 00:00:00

abstract：:Quantum Zeno effect shows that frequent observations can slow down or even stop the unitary time evolution of an unstable quantum system. This effect can also be regarded as a physical consequence of the statistical indistinguishability of neighboring quantum states. The accessibility of quantum Zeno dynamics under un...

journal_title：Scientific reports

authors： Zhang YR,Fan H

更新日期：2015-06-23 00:00:00

abstract：:The role of the actin cytoskeleton in relation to mitochondria function and dynamics is only recently beginning to be recognized. Myo19 is an actin-based motor that is bound to the outer mitochondrial membrane and promotes the localization of mitochondria to filopodia in response to glucose starvation. However, how gl...

journal_title：Scientific reports

authors： Shneyer BI,Ušaj M,Wiesel-Motiuk N,Regev R,Henn A

更新日期：2017-09-14 00:00:00

abstract：:Glaucoma is a leading cause of irreversible vision loss predicted to affect more than 100 million people by 2040. Intraocular pressure (IOP) reduction prevents development of glaucoma and vision loss from glaucoma. Glaucoma surgeries reduce IOP by facilitating aqueous humor outflow through a vent fashioned from the wa...

journal_title：Scientific reports

authors： Parikh KS,Josyula A,Omiadze R,Ahn JY,Ha Y,Ensign LM,Hanes J,Pitha I

更新日期：2020-07-31 00:00:00

abstract：:Structural isomers, molecules having the same chemical formula but with atoms bonded in different order, are hard to identify using conventional spectroscopy and mass spectrometry. They exhibit virtually indistinguishable mass spectra when ionized by electrons. Laser mass spectrometry based on photoionization of the i...

journal_title：Scientific reports

authors： Alharbi A,Boguslavskiy AE,Austin D,Thiré N,Wood D,Hawkins P,McGrath F,Johnson AS,Lopez-Quintas I,Schmidt B,Légaré F,Marangos JP,Le AT,Bhardwaj R

更新日期：2018-02-28 00:00:00

abstract：:Attention can be allocated to mental representations to select information from working memory. To date, it remains ambiguous whether such retroactive shifts of attention involve the inhibition of irrelevant information or the prioritization of relevant information. Investigating asymmetries in posterior alpha-band os...

journal_title：Scientific reports

authors： Klatt LI,Getzmann S,Begau A,Schneider D

更新日期：2020-08-17 00:00:00

abstract：:Quantifying multi-molecular complex assembly in specific cytoplasmic compartments is crucial to understand how cells use assembly/disassembly of these complexes to control function. Currently, biophysical methods like Fluorescence Resonance Energy Transfer and Fluorescence Correlation Spectroscopy provide quantitative...

journal_title：Scientific reports

authors： Vedula P,Cruz LA,Gutierrez N,Davis J,Ayee B,Abramczyk R,Rodriguez AJ

更新日期：2016-06-30 00:00:00

abstract：:Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patie...

journal_title：Scientific reports

authors： Seppa K,Toots M,Reimets R,Jagomäe T,Koppel T,Pallase M,Hasselholt S,Krogsbæk Mikkelsen M,Randel Nyengaard J,Vasar E,Terasmaa A,Plaas M

更新日期：2019-10-31 00:00:00

abstract：:Pooled data analysis in the field of maternal and child nutrition rarely incorporates data from low- and middle-income countries and existing studies lack a description of the methods used to harmonize the data and to assess heterogeneity. We describe the creation of the Brazilian Maternal and Child Nutrition Consorti...

journal_title：Scientific reports

authors： Carrilho TRB,Farias DR,Batalha MA,Costa NCF,Rasmussen KM,Reichenheim ME,Ohuma EO,Hutcheon JA,Kac G,Brazilian Maternal and Child Nutrition Consortium.

更新日期：2020-09-10 00:00:00

abstract：:In this study, a simple technique was developed for the electrochemical detection of anionic analytes in weakly supported media. This was conducted by the use of electrochemical paper-based analytical devices (ePADs). A sensing platform was modified with nereistoxin and used to determine nitrite as a case study. The e...

journal_title：Scientific reports

authors： Khoshroo A,Fattahi A

更新日期：2020-09-03 00:00:00

abstract：:Accidental transmission of prions during neurosurgery has been reported as a consequence of re-using contaminated surgical instruments. Several decontamination methods have been studied using the 263K-hamster prion; however, no studies have directly evaluated human prions. A newly developed in vitro amplification syst...

journal_title：Scientific reports

authors： Mori T,Atarashi R,Furukawa K,Takatsuki H,Satoh K,Sano K,Nakagaki T,Ishibashi D,Ichimiya K,Hamada M,Nakayama T,Nishida N

更新日期：2016-04-26 00:00:00

abstract：:In neuroblastoma (NB), one of the most common paediatric solid tumours, activation of anaplastic lymphoma kinase (ALK) is often associated with poor outcomes. Although genetic studies have identified copy number alteration and nonsynonymous mutations of ALK, the regulatory mechanism of ALK signalling at protein levels...

journal_title：Scientific reports

authors： Satoh S,Takatori A,Ogura A,Kohashi K,Souzaki R,Kinoshita Y,Taguchi T,Hossain MS,Ohira M,Nakamura Y,Nakagawara A

更新日期：2016-09-08 00:00:00

abstract：:Endothelial and mesenchymal stromal cells (ECs/MSCs) are crucial components of hematopoietic bone marrow stem cell niches. Both cell types appear to be required to support the maintenance and expansion of multipotent hematopoietic cells, i.e. hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs). With the...

journal_title：Scientific reports

authors： Radtke S,Görgens A,da Conceição Castro SV,Kordelas L,Köninger A,Dürig J,Möllmann M,Horn PA,Giebel B

更新日期：2019-09-09 00:00:00

abstract：:Materials with a layered structure have attracted tremendous attention because of their unique properties. The ultrathin nanosheet structure can result in extremely rapid intercalation/de-intercalation of Na ions in the charge-discharge progress. Herein, we report a manganese oxide with pre-intercalated K and Na ions ...

journal_title：Scientific reports

authors： Feng M,Du Q,Su L,Zhang G,Wang G,Ma Z,Gao W,Qin X,Shao G

更新日期：2017-05-22 00:00:00

abstract：:Models of biological processes are often subject to different sources of noise. Developing an understanding of the combined effects of different types of uncertainty is an open challenge. In this paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which combines both agent-to-age...

journal_title：Scientific reports

authors： Herrerías-Azcué F,Galla T

更新日期：2017-10-11 00:00:00

abstract：:Our motor system can generate representations which carry information about the goals of another agent's actions. However, it is not known whether motor representations play a deeper role in social understanding, and, in particular, whether they enable tracking others' beliefs. Here we show that, for adult observers, ...

journal_title：Scientific reports

authors： Low J,Edwards K,Butterfill SA

更新日期：2020-07-09 00:00:00

abstract：:Resistant starch (RS) has been reported to reduce body fat in obese mice. However, this effect has not been demonstrated in humans. In this study, we tested the effects of RS in 19 volunteers with normal body weights. A randomized, double-blinded and crossover design clinical trial was conducted. The study subjects we...

journal_title：Scientific reports

authors： Zhang L,Ouyang Y,Li H,Shen L,Ni Y,Fang Q,Wu G,Qian L,Xiao Y,Zhang J,Yin P,Panagiotou G,Xu G,Ye J,Jia W

更新日期：2019-03-20 00:00:00

abstract：:Iron deposits are a phenotypic trait of tumor-associated macrophages (TAMs). Histological iron imaging and contrast-agent free magnetic resonance imaging (MRI) can detect these deposits, but their presence  in human cancer, and correlation with immunotherapeutic response is largely untested. Here, primarily using thes...

journal_title：Scientific reports

authors： Leftin A,Ben-Chetrit N,Joyce JA,Koutcher JA

更新日期：2019-01-29 00:00:00

abstract：:Cathelicidins are short cationic host defense peptides and play a central role in host innate immune system. Here we identified two novel cathelicidins, Cl-CATH2 and 3, from Columba livia. Evolutionary analysis of avian cathelicidins via phylogenetic tree and Ka/Ks calculations supported the positive selection that pr...

journal_title：Scientific reports

authors： Yu H,Lu Y,Qiao X,Wei L,Fu T,Cai S,Wang C,Liu X,Zhong S,Wang Y

更新日期：2015-07-21 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult-to-treat infection. Increasing efforts have been taken to mitigate the epidemics and to avoid potential outbreaks in low endemic settings. Understanding the population dynamics of MRSA is essential to identify the causal mechanisms driving the epidemics...

journal_title：Scientific reports

authors： Rocha LEC,Singh V,Esch M,Lenaerts T,Liljeros F,Thorson A

更新日期：2020-06-09 00:00:00

abstract：:In addition to its role in sister chromatid cohesion, genome stability and integrity, the cohesin complex is involved in gene transcription. Mutations in core cohesin subunits SMC1A, SMC3 and RAD21, or their regulators NIPBL and HDAC8, cause Cornelia de Lange syndrome (CdLS). Recent evidence reveals that gene expressi...

journal_title：Scientific reports

authors： Mannini L,C Lamaze F,Cucco F,Amato C,Quarantotti V,Rizzo IM,Krantz ID,Bilodeau S,Musio A

更新日期：2015-11-19 00:00:00

abstract：:Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, m...

journal_title：Scientific reports

authors： Lambert E,Fuselier E,Ramont L,Brassart B,Dukic S,Oudart JB,Dupont-Deshorgue A,Sellier C,Machado C,Dauchez M,Monboisse JC,Maquart FX,Baud S,Brassart-Pasco S

更新日期：2018-06-29 00:00:00

abstract：:Treatment of decompensated heart failure often includes administration of levosimendan. Myeloperoxidase (MPO) is released during polymorphonuclear neutrophil (PMN) degranulation, and mediates dysregulation of vascular tone in heart failure. We evaluated the effects of levosimendan-treatment on MPO in patients with acu...

journal_title：Scientific reports

authors： Adam M,Meyer S,Knors H,Klinke A,Radunski UK,Rudolph TK,Rudolph V,Spin JM,Tsao PS,Costard-Jäckle A,Baldus S

更新日期：2015-04-13 00:00:00

abstract：:Protein corona significantly affects in vivo fate of nanoparticles including biodistribution and half-life. Without manipulating the physicochemical properties of nanoparticles with considering their biointerference, attaining effective treatment protocols is impossible. For this reason, protein corona evolution and b...

journal_title：Scientific reports

authors： Tekie FSM,Hajiramezanali M,Geramifar P,Raoufi M,Dinarvand R,Soleimani M,Atyabi F

更新日期：2020-06-15 00:00:00

abstract：:Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...

journal_title：Scientific reports

authors： Bajgain P,Russell B,Mohammadi M

更新日期：2018-05-04 00:00:00

abstract：:At the post-synaptic density (PSD), large protein complexes dynamically form and dissociate in response to synaptic activity, comprising the biophysical basis for learning and memory. The use of detergents to isolate the PSD and release its membrane-associated proteins complicates studies of these activity-dependent p...

journal_title：Scientific reports

authors： Lautz JD,Gniffke EP,Brown EA,Immendorf KB,Mendel RD,Smith SEP

更新日期：2019-07-26 00:00:00