Abstract:
:Pooled data analysis in the field of maternal and child nutrition rarely incorporates data from low- and middle-income countries and existing studies lack a description of the methods used to harmonize the data and to assess heterogeneity. We describe the creation of the Brazilian Maternal and Child Nutrition Consortium dataset, from multiple pooled longitudinal studies, having gestational weight gain (GWG) as an example. Investigators of the eligible studies published from 1990 to 2018 were invited to participate. We conducted consistency analysis, identified outliers, and assessed heterogeneity for GWG. Outliers identification considered the longitudinal nature of the data. Heterogeneity was performed adjusting multilevel models. We identified 68 studies and invited 59 for this initiative. Data from 29 studies were received, 21 were retained for analysis, resulting in a final sample of 17,344 women with 72,616 weight measurements. Fewer than 1% of all weight measurements were flagged as outliers. Women with pre-pregnancy obesity had lower values for GWG throughout pregnancy. GWG, birth length and weight were similar across the studies and remarkably similar to a Brazilian nationwide study. Pooled data analyses can increase the potential of addressing important questions regarding maternal and child health, especially in countries where research investment is limited.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Carrilho TRB,Farias DR,Batalha MA,Costa NCF,Rasmussen KM,Reichenheim ME,Ohuma EO,Hutcheon JA,Kac G,Brazilian Maternal and Child Nutrition Consortium.doi
10.1038/s41598-020-71612-8subject
Has Abstractpub_date
2020-09-10 00:00:00pages
14869issue
1issn
2045-2322pii
10.1038/s41598-020-71612-8journal_volume
10pub_type
杂志文章abstract::Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis. However, little is known about the potential role of DMT1 in the pathogenesis of anemia from patients with inflammatory bowel disease (IBD). Herein, we investigated expression of DMT1 in the intesti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16344
更新日期:2015-11-17 00:00:00
abstract::Membrane proteins are distinguished from soluble proteins by their insertion into biological membranes. This insertion is achieved via a noticeable arrangement of hydrophobic amino acids that are exposed at the surface of the protein, and renders the interaction with the aliphatic tails of lipids more energetically fa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17216-1
更新日期:2017-12-05 00:00:00
abstract::Alterations in muscle milieu are suggested as important activity of peripheral drive in patients with chronic musculoskeletal pain (CMP). Microdialysis (MD) has been used in monitoring altered metabolic response pattern in muscles. However, the insertion of MD probe causes a local tissue trauma. Whether and how metabo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21185-4
更新日期:2018-02-14 00:00:00
abstract::In this paper, we evaluated the power of microbiome measures taken at three time points over the growth test period (weaning, 15 and 22 weeks) to foretell growth and carcass traits in 1039 individuals of a line of crossbred pigs. We measured prediction accuracy as the correlation between actual and predicted phenotype...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43031-x
更新日期:2019-04-25 00:00:00
abstract::Magnetic resonance imaging (MRI) is a widely used non-invasive methodology for both preclinical and clinical studies. However, MRI lacks molecular specificity. Molecular contrast agents for MRI would be highly beneficial for detecting specific pathological lesions and quantitatively evaluating therapeutic efficacy in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80181-9
更新日期:2021-01-08 00:00:00
abstract::The ability of metasurfaces to manipulate light at the subwavelength scale offers unprecedented functionalities for passive and active lasing devices. However, applications of metasurfaces to optical devices are rare due to fabrication difficulties. Here, we present quantum dot light emitting diodes (QDLEDs) with a me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15254-3
更新日期:2017-11-07 00:00:00
abstract::Spatially uniform reconstitution of dried reagents is critical to the function of paper microfluidic devices. Advancing fluid fronts in paper microfluidic devices drive (convect) and concentrate rehydrated reagents to the edges, causing steep chemical gradients and imperfect mixing. This largely unsolved problem in pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52202-9
更新日期:2019-10-31 00:00:00
abstract::Micro/nanophotonic structures that are capable of optical wave-front shaping are implemented in optical waveguides and passive optical devices to alter the phase of the light propagating through them. The beam division directions and beam power distribution depend on the design of the micro/nanostructures. The ultimat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44333
更新日期:2017-03-09 00:00:00
abstract::All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling molecule during embryonic and fetal development and is necessary for maternal health. Fetal exposure to endogenous atRA is tightly regulated during gestation in a tissue specific manner and maternal exposure to exogenous retino...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40995-8
更新日期:2019-03-15 00:00:00
abstract::High-carrier mobility semiconductors on insulators are essential for fabricating advanced thin-film transistors, allowing for three-dimensional integrated circuits or high-performance mobile terminals. We investigate the low-temperature (375-450 °C) solid-phase crystallization (SPC) of Ge on a glass substrate, focusin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17273-6
更新日期:2017-12-05 00:00:00
abstract::3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate the e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62527-5
更新日期:2020-03-27 00:00:00
abstract::Previous studies have indicated that memory training may help older people improve cognition. However, evidence regarding who will benefit from such memory trainings has not been fully discovered yet. Understanding the clinical and neural inter-individual differences for predicting cognitive improvement is important f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19390-2
更新日期:2018-01-18 00:00:00
abstract::Obstructive sleep apnea (OSA) is associated with increasing risk of recurrent stroke and mortality. Nasogastric tubes used by dysphagic stroke patients may interfere with nasal continuous positive airway pressure (CPAP) due to air leakage. This study was evaluated the effects and short-term tolerability of high-flow n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65335-z
更新日期:2020-05-22 00:00:00
abstract::The regulation of inflammatory responses by innate immune receptors is recognized as a crucial step in the development of atherosclerosis, although the precise molecular mechanisms remain to be elucidated. This study focused on illustrating the roles of dendritic cell-specific intercellular adhesion molecule-3-grabbin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03740-7
更新日期:2017-06-12 00:00:00
abstract::Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78832-y
更新日期:2020-12-17 00:00:00
abstract::Exploiting pattern formation - such as that observed in nature - in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14787
更新日期:2015-10-06 00:00:00
abstract::We report measurements of the thermal conductance of a structure made from commercial Acrylonitrile Butadiene Styrene (ABS) modules, known as LEGO® blocks, in the temperature range from 70 mK to 1.8 K. A power law for the sample's thermal conductivity κ = (8.7 ± 0.3) × 10-5 T 1.75±0.02 WK-1 m-1 was determined. We conc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55616-7
更新日期:2019-12-23 00:00:00
abstract::Ascertaining the existence of hidden objects in a complex system, objects that cannot be observed from the external world, not only is curiosity-driven but also has significant practical applications. Generally, uncovering a hidden node in a complex network requires successful identification of its neighboring nodes, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03944
更新日期:2014-02-03 00:00:00
abstract::The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the impact of JDP2 on heart failure progression. Therefore, during birth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26052-w
更新日期:2018-05-16 00:00:00
abstract::There is a growing interest in developing microphysiological systems that can be used to model both normal and pathological human organs in vitro. This "organs-on-chips" approach aims to capture key structural and physiological characteristics of the target tissue. Here we describe in vitro vascularized microtumors (V...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31589
更新日期:2016-08-23 00:00:00
abstract::This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42132-x
更新日期:2019-04-04 00:00:00
abstract::This study was to evaluate the effect of Epigallocatechin-3-gallate (EGCG) on the bond strength of two adhesive systems to the Sodium hypochlorite (NaOCl) treated intraradicular dentin. The roots were accepted regular root canal treatments and post space preparations, and further divided into eight groups according to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04107-8
更新日期:2017-06-26 00:00:00
abstract::Recently, some very tight constraints of annihilating dark matter have been obtained from gamma-ray data of the Milky Way and Milky Way dwarf spheroidal satellite galaxies. In this article, we report that there are two excellent galaxy clusters (A2877 and Fornax) which can provide interesting constraints for annihilat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14950-4
更新日期:2017-11-02 00:00:00
abstract::Pseudomonas aeruginosa is an opportunistic pathogen that thrives in diverse environments and causes a variety of human infections. Pseudomonas aeruginosa AG1 (PaeAG1) is a high-risk sequence type 111 (ST-111) strain isolated from a Costa Rican hospital in 2010. PaeAG1 has both blaVIM-2 and blaIMP-18 genes encoding for...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70581-2
更新日期:2020-08-13 00:00:00
abstract::In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract ("formants"), rather than in the rate of tissue vibration in the sound source ("pitch"). Anatomical constraints on the vocal tract's size render formants honest cues to size in many bird and mammal species, but it i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01948-1
更新日期:2017-05-12 00:00:00
abstract::This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71089-5
更新日期:2020-08-26 00:00:00
abstract::The most obvious method to observe transplanted islets in the liver is direct biopsy, but the distribution and location of the best biopsy site in the recipient's liver are poorly understood. Islets transplanted into the whole liver of five diabetic cynomolgus monkeys that underwent insulin-independent survival for an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57701-8
更新日期:2020-01-21 00:00:00
abstract::A large retreat of sea-ice in the 'stormy' Atlantic Sector of the Arctic Ocean has become evident through a series of record minima for the winter maximum sea-ice extent since 2015. Results from the Norwegian young sea ICE (N-ICE2015) expedition, a five-month-long (Jan-Jun) drifting ice station in first and second yea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45574-5
更新日期:2019-06-25 00:00:00
abstract::Bacterial cell wall is targeted by many antibiotics. Among them are lantibiotics, which realize their function via interaction with plasma membrane lipid-II molecule - a chemically conserved part of the cell wall synthesis pathway. To investigate structural and dynamic properties of this molecule, we have performed a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01678
更新日期:2013-01-01 00:00:00
abstract::With the development of next generation sequencing, more and more common inherited diseases have been reported. However, accurate and convenient molecular diagnosis cannot be achieved easily because of the enormous size of disease causing mutations. In this study, we introduced a new single-step method for the genetic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30151-z
更新日期:2018-08-03 00:00:00