Thiolation of low-density lipoproteins and their interaction with L2C leukemic lymphocytes.

abstract：:The metabolism of the phospholipids of the submaxillary gland are studied after intraperitoneal injections of [32P]-orthophosphate in several groups of rats. The gland contains mainly phosphatidylcholines and phosphatidylethanolamines and in smaller quantities phosphatidylinositols, phosphatidylserines, sphingomyelins...

journal_title：Biochimie

authors： Leclercq C,Di Costanzo G

更新日期：1976-01-01 00:00:00

abstract：:Changes in the cytosolic Ca(2+) concentration ([Ca(2+)](c)) translate a variety of extracellular signals into widely diverse intracellular effects, ranging from secretion to movement, proliferation and also cell death. As regards the last one, it has long been known that large [Ca(2+)](c) increases lead cells to death...

journal_title：Biochimie

authors： Pinton P,Ferrari D,Rapizzi E,Di Virgilio F,Pozzan T,Rizzuto R

更新日期：2002-02-01 00:00:00

abstract：:Thyroid peroxidase (TPO) is the key enzyme involved in thyroid hormone synthesis. Autoantibodies to TPO (TPOAbs) are a hallmark of autoimmune thyroid disease (AITD). Here, we highlight recent progress over several years in understanding TPO biochemistry and function in various pathologies. TPO undergoes complex post-t...

journal_title：Biochimie

authors： Godlewska M,Banga PJ

更新日期：2019-05-01 00:00:00

abstract：:The product of the sex-determining gene SRY is a member of the HMG box containing protein superfamily. The HMG box is a DNA-binding domain of about 80 amino acids shared by many proteins with diverse functions. It seems that the functions of the full length protein are restricted to the HMG box but their molecular bas...

journal_title：Biochimie

authors： Soullier S,Poulat F,Boizet-Bonhoure B,Calas B,Bennes R,Heitz F,Berta P

更新日期：1994-01-01 00:00:00

abstract：:Several mechanistic hypotheses have been proposed for how carotenoid pigmentation of integumentary structures can serve as an honest signal of individual quality. These hypotheses are founded on proposed links between carotenoids, immuno responsiveness, and oxidative stress, but an absence of biochemical information o...

journal_title：Biochimie

authors： Johnson JD,Hill GE

更新日期：2013-02-01 00:00:00

abstract：:We have synthesized and examined a number of fully and partly self-complementary palindromic oligodeoxynucleotides for their ability to assume in solution a unimolecular hairpin structure. The main results obtained by a combined optical and electrophoresis investigation show that: (i) DNA folding needs not be driven b...

journal_title：Biochimie

authors： Xodo LE,Manzini G,Quadrifoglio F,van der Marel G,van Boom JH

更新日期：1989-07-01 00:00:00

abstract：:We identified a T-to-C mutation 2 nucleotides (nt) upstream from the AG in a GT-AG intron between exons 2 and 3 in the human T-cell leukemia virus type I (HTLV-I) tax mRNA. This mutation resulted in the preferential usage of an alternative splice site, causing a 75-nt elongation of tax mRNA and reduced production of v...

journal_title：Biochimie

authors： Ohsugi T

更新日期：2006-02-01 00:00:00

abstract：:The x-ray structure of the monotopic membrane protein (S)-mandelate dehydrogenase (MDH) from Pseudomonas putida reveals an inherent flexibility of its membrane binding segment that might be important for its biological activity. The surface of MDH exhibits a concentration of the positive charges on one side and the ne...

journal_title：Biochimie

authors： Sukumar N,Liu S,Li W,Mathews FS,Mitra B,Kandavelu P

更新日期：2018-11-01 00:00:00

abstract：:The suhB gene of Escherichia coli has been defined by its mutant allele that suppresses other mutants in secY, rpoH, dnaB, and era. The suhB mutant by itself is cold sensitive, and is shown to have defects in protein synthesis. Starting with the suhB cold-sensitive mutant, cold-resistant suppressors were isolated. The...

journal_title：Biochimie

authors： Inada T,Nakamura Y

更新日期：1995-01-01 00:00:00

abstract：:A series of halomethylated derivatives of dihydrocoumarins has been found to inhibit irreversibly proteases and esterases. alpha-Chymotrypsin, subtilish, elastase are rapidly inactivated in the presence of these compounds, while trypsin, kallicrein, papain are inhibited more slowly. Esterases like acetylcholinesterase...

journal_title：Biochimie

authors： Béchet JJ,Dupaix A,Roucous C,Bonamy AM

更新日期：1977-01-01 00:00:00

abstract：:Translational autocontrol of the expression of the ribosomal protein S15 proceeds through the transitory formation of a pseudoknot. A synopsis of the known data is used to propose a molecular model of the mechanism involved and for the role of the pseudoknot. This latter structure is able to recruit 30S ribosomal subu...

journal_title：Biochimie

authors： Bénard L,Philippe C,Ehresmann B,Ehresmann C,Portier C

更新日期：1996-01-01 00:00:00

abstract：:The inhibition rates and spectral characteristics of 2 probes specific for the active-site serine residue of proteases were examined for evidence of conformational change of the proteases upon their binding to alpha 2-macroglobulin (alpha 2M). Elastase, chymotrypsin, trypsin, and plasmin were reacted with (7-nitrobenz...

journal_title：Biochimie

authors： Martini JL,Pochon F

更新日期：1989-03-01 00:00:00

abstract：:The ability to measure the thermodynamic stability of proteins with precision is important for both academic and applied research. Such measurements rely on mathematical models of the protein denaturation profile, i.e. the relation between a global protein signal, corresponding to the folding states in equilibrium, an...

journal_title：Biochimie

authors： Bedouelle H

更新日期：2016-02-01 00:00:00

abstract：:PA1b (Pea Albumin 1b) is a peptide toxin lethal for certain insects. This paper shows that the cultured insect cells Sf9 are sensitive to the toxin and display a high-affinity binding site for PA1b. Mammalian cells are not sensitive and no binding activity was detected. Signs of apoptosis of the Sf9 cells were observe...

journal_title：Biochimie

authors： Rahioui I,Laugier C,Balmand S,Da Silva P,Rahbe Y,Gressent F

更新日期：2007-12-01 00:00:00

abstract：:The molecular basis for the essential role of cholesterol in mammalian (and other cholesterol-requiring) cells has long been the object of intense interest. Cholesterol has been found to modulate the function of membrane proteins critical to cellular function. Current literature supports two mechanisms for this modula...

journal_title：Biochimie

authors： Yeagle PL

更新日期：1991-10-01 00:00:00

abstract：:We present an approach for designing a knowledge-based system, called Sequence Acquisition In Context (SAIC), that will be able to cooperate with a biologist in the analysis of DNA sequences. The main task of the system is the acquisition of the expert knowledge that the biologist uses for solving ambiguities from gel...

journal_title：Biochimie

authors： Brézillon PJ,Zaraté P,Saci F

更新日期：1993-01-01 00:00:00

abstract：:Extracellular Hsp70 (eHsp70) can activate immune cells via Toll-like receptors (TLR) 2 and 4, and induce cytokine synthesis. The aim of this study was to explore inflammation-associated effects of eHsp70 alone and in combination with cigarette smoke extract (CSE) in primary bronchial epithelial cells. We assessed IL-6...

journal_title：Biochimie

authors： Hulina-Tomašković A,Heijink IH,Jonker MR,Somborac-Bačura A,Grdić Rajković M,Rumora L

更新日期：2019-01-01 00:00:00

abstract：:Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems ...

journal_title：Biochimie

authors： Nasir MN,Crowet JM,Lins L,Obounou Akong F,Haudrechy A,Bouquillon S,Deleu M

更新日期：2016-11-01 00:00:00

abstract：:The lipoprotein complex from human gallbladder bile was challenged with anti-IgA and anti-IgG antisera in order to determine whether the apolipoprotein complex isolated from the detergent-free form of bile lipoprotein contains IgA and IgG. The apolipoprotein complex indeed crossreacts with anti-IgA and anti-IgG. In ad...

journal_title：Biochimie

authors： Vigne JL,Nalbone G,Lafont H,Lairon D,Chabert C,Domingo N,Hauton JC

更新日期：1981-10-01 00:00:00

abstract：:The binding properties of Mg2+, Mn2+ and Co2+ to yeast mitochondrial oligomycin sensitive ATPase complex are studied, as reflected by their catalytic effect (hydrolysis of ATP or pNPP, a pseudo substrate) or by a physical parameter (atomic absorption, electron paramagnetic reasonance of Mn2+, enhanced fluorescence of ...

journal_title：Biochimie

authors： Jallon JM,Spyridakis A,Cosson J

更新日期：1977-01-01 00:00:00

abstract：:The Escherichia coli Fis protein is a dimeric DNA-binding protein whose specific binding sites share a weak consensus sequence. Use of the gel retardation technique indicates that binding of Fis on a linear DNA fragment leads to the formation of a ladder of defined retarded complexes, independently of the presence of ...

journal_title：Biochimie

authors： Bétermier M,Galas DJ,Chandler M

更新日期：1994-01-01 00:00:00

abstract：:All hormones and neurotransmitters which provoke their intracellular effects by increasing the cytosolic concentration of Ca2+ in their target cells also stimulate the breakdown of inositol phospholipids. Much evidence suggests that this breakdown is intimately involved in the mechanism which couples cell-surface rece...

journal_title：Biochimie

authors： Kirk CJ,Guillon G,Balestre MN,Creba JA,Michell RH,Jard S

更新日期：1985-10-01 00:00:00

abstract：:The eukaryotic ribosomal protein S15 is a key component of the decoding site in contrast to its prokaryotic counterpart, S19p, which is located away from the mRNA binding track on the ribosome. Here, we determined the oligopeptide of S15 neighboring the A site mRNA codon on the human 80S ribosome with the use of mRNA ...

journal_title：Biochimie

authors： Khairulina J,Graifer D,Bulygin K,Ven'yaminova A,Frolova L,Karpova G

更新日期：2010-07-01 00:00:00

abstract：:Acinetobacter baumannii encodes all enzymes required in the tricarboxylic acid (TCA) cycle and glyoxylate bypass except for isocitrate dehydrogenase kinase/phosphatase (IDHKP), which can phosphorylate isocitrate dehydrogenase (IDH) at a substrate-binding Ser site and control the carbon flux in enterobacteria, such as ...

journal_title：Biochimie

authors： Song P,Wang ML,Zheng QY,Wang P,Zhu GP

更新日期：2020-12-05 00:00:00

abstract：:The concept of a stem cell subpopulation as understood from normal epithelial tissue or bone marrow function has been extended to our understanding of cancer tissue and is now the target of treatment efforts specifically directed to this subpopulation. In glioblastoma, as well as in other cancers, increased expression...

journal_title：Biochimie

authors： Rappa F,Cappello F,Halatsch ME,Scheuerle A,Kast RE

更新日期：2013-04-01 00:00:00

abstract：:Contradictory results for concentrations of vitamin B12, holotranscobalamin (holoTC), and methylmalonic acid (MMA) have been reported. We tested the hypothesis that the extracellular vitamin B12 markers are not reflecting the intracellular vitamin B12-dependent biochemical reactions in individuals with type 2 diabetes...

journal_title：Biochimie

authors： Obeid R,Jung J,Falk J,Herrmann W,Geisel J,Friesenhahn-Ochs B,Lammert F,Fassbender K,Kostopoulos P

更新日期：2013-05-01 00:00:00

abstract：:High-mobility group box-1 (HMGB1) is remarkably mobile in living cells, which reflects its ability to interact only transiently with both DNA and protein. This property is likely essential for HMGB1 nuclear activities. Nonetheless the weak interaction of HMGB1 with DNA and/or protein partners has also been a major lim...

journal_title：Biochimie

authors： Messmer M,Klein C,Boniface R,Gnädig NF,Lecerf M,Barnay-Verdier S,Maréchal V

更新日期：2013-04-01 00:00:00

abstract：:Toyocamycin (TMC), an adenosine analog has been previously reported to inhibit both number and infectivity of retrovirus particles released by chronically infected cells (Bonar et al., 1970; Riman, 1971; Mauchauffé et al., 1979). We have previously shown that loss of infectivity could result from the incorporation of ...

journal_title：Biochimie

authors： Mathieu-Mahul D,Barque JP,Mauchauffe M,Peraudeau L,Larsen CJ

更新日期：1981-01-01 00:00:00

abstract：:The chicken ovalbumin (Ov) gene is one of the best models to study tissue-specific gene regulation because it is only expressed in the oviduct. In this paper, a tissue-specific element was characterized by 5'-flanking region deletion in combination with in vivo gene electroporation (EP). Plasmids with varying lengths ...

journal_title：Biochimie

authors： Park HM,Sanders MM,Suzuki T,Muramatsu T

更新日期：2006-12-01 00:00:00

abstract：:Bacterial superantigens (SAg) are the most potent activators of human T lymphocytes and recombinant immunotoxin using bacterial SAg shows promising clinical values. To engineer superantigen for immunotherapy of hepatocellular carcinoma, we genetically fused the superantigen staphylococcus enterotoxin A (SEA(D(227)A)) ...

journal_title：Biochimie

authors： Hao HJ,Jiang YQ,Zheng YL,Ma R,Yu DW

更新日期：2005-08-01 00:00:00