Abstract：
:All hormones and neurotransmitters which provoke their intracellular effects by increasing the cytosolic concentration of Ca2+ in their target cells also stimulate the breakdown of inositol phospholipids. Much evidence suggests that this breakdown is intimately involved in the mechanism which couples cell-surface receptor activation to intracellular Ca2+ mobilization. Recent results indicate that the primary, receptor-mediated event in stimulated cells is a phosphodiesteric hydrolysis of phosphatidylinositol 4,5-bisphosphate to yield inositol trisphosphate and diacylglycerol. It is likely that both products of this reaction fulfill 'second messenger' roles within stimulated cells.
journal_name
Biochimiejournal_title
Biochimieauthors
Kirk CJ,Guillon G,Balestre MN,Creba JA,Michell RH,Jard Sdoi
10.1016/s0300-9084(85)80115-2subject
Has Abstractpub_date
1985-10-01 00:00:00pages
1161-7issue
10-11eissn
0300-9084issn
1638-6183pii
S0300-9084(85)80115-2journal_volume
67pub_type
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