Abstract:
:A series of halomethylated derivatives of dihydrocoumarins has been found to inhibit irreversibly proteases and esterases. alpha-Chymotrypsin, subtilish, elastase are rapidly inactivated in the presence of these compounds, while trypsin, kallicrein, papain are inhibited more slowly. Esterases like acetylcholinesterase and butyrylcholinesterase also lose activity in their presence. Two structural features of these inactivators are essential for inhibition: a reactive cis-ester function and an alkylating function. Analogues of these derivatives having only one of these characteristics are inefficient. Therefore it is suggested that the efficiency of these bifunctional reagents is due to their character of potential "suicide substrates".
journal_name
Biochimiejournal_title
Biochimieauthors
Béchet JJ,Dupaix A,Roucous C,Bonamy AMdoi
10.1016/s0300-9084(77)80140-5subject
Has Abstractpub_date
1977-01-01 00:00:00pages
241-6issue
3eissn
0300-9084issn
1638-6183pii
S0300-9084(77)80140-5journal_volume
59pub_type
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