Abstract:
:The cellular concentration of cyclic nucleotides is largely dependent upon the activity of the enzymatic system responsible for their degradation: cyclic nucleotide phosphodiesterase. This enzymatic system thus plays a crucial role in the regulation of the multiple functions which are modulated by cyclic nucleotides in the organism. Many methodological problems, as well as the complexity of the phosphodiesterase system have long maintained a confusion in this field. Recent progresses (purification to homogeneity of some enzymatic forms, discovery of regulatory mechanisms, particularly) have brought a considerable evolution in the knowledge of the system. It is now well established that cyclic nucleotide phosphodiesterase exists under several isoenzymatic forms, the properties and distribution of which largely differ from a tissue to another. Some of these forms are relatively well characterized, while the representativity of others is still discussed. The significance of this multiplicity of isoenzymes, and their interrelationships are presently under study. A very interesting aspect in the study of this enzymatic system is that it is submitted to several physiological regulatory processes. Recent studies on this point suggest that phosphodiesterase might play a major role in the response of the organism to several hormones. These fundamental studies of phosphodiesterase system find a most interesting application in the pharmacological field. Indeed, numerous synthetic compounds which inhibit the enzyme present a strong pharmacological interest.
journal_name
Biochimiejournal_title
Biochimieauthors
Nemoz G,Prigent AFdoi
10.1016/0300-9084(84)90203-7subject
Has Abstractpub_date
1984-02-01 00:00:00pages
139-50issue
2eissn
0300-9084issn
1638-6183pii
0300-9084(84)90203-7journal_volume
66pub_type
杂志文章相关文献
BIOCHIMIE文献大全abstract::Two forms of baker's yease valyl-tRNA synthetase have been purified to apparent homogeneity by classical methods. It was demonstrated that one of the two forms of the enzyme originates from the other by proteolysis, the respective amounts of each form depending on the physiological state of the yeast. The species main...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/s0300-9084(76)80579-2
更新日期:1975-01-01 00:00:00
abstract::Many human conditions, including neurological diseases, atherosclerosis, cancer, diabetic complications and aging, are thought to be associated with oxidative stress (OS). The development of reliable and informative markers for the characterization of OS in humans is thus highly important. Various endogenous markers a...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2012.03.005
更新日期:2013-03-01 00:00:00
abstract::RNA-protein crosslinks were introduced into the 40S ribosomal subunits from Saccharomyces cerevisiae by mild UV treatment. Proteins crosslinked to the 18S rRNA molecule were separated from free proteins by repeated extraction of the treated subunits and centrifugation in glycerol gradients. After digestion with RNase ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/0300-9084(89)90024-2
更新日期:1989-11-01 00:00:00
abstract::It is now over 10 years since the discovery of peroxisome proliferator activated receptor gamma (PPAR gamma) and its unique role in adipogenesis. The subsequent identification of PPAR gamma as the target of insulin sensitizing drugs certified this ligand-regulated transcription factor as an exciting link between adipo...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2004.10.021
更新日期:2005-01-01 00:00:00
abstract::Cotranslational translocation of exportable proteins across the RER membrane prior to their release into the extracellular space has been essentially described by use of canine pancreatic microsomal membranes. Intracisternal segregation of nascent secretory proteins was observed to be irreversible and proteolytic remo...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/0300-9084(88)90194-0
更新日期:1988-09-01 00:00:00
abstract::Information on the subcellular localization of bacterial proteins is essential for protein function prediction, genome annotation and drug design. Here we proposed a novel approach to predict the subcellular localization of bacterial proteins by fusing features from position-specific score matrix (PSSM), Gene Ontology...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2014.06.001
更新日期:2014-09-01 00:00:00
abstract::With the increase of multidrug resistance, novel anti-leukemia agents with diverse mechanisms of action are required to address this challenge. NK-18, the core region of mammalian derived protein NK-lysin, effectively inhibited the viability of both multidrug resistant and sensitive leukemia cell lines. Meanwhile, thi...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2018.02.001
更新日期:2018-04-01 00:00:00
abstract::Staphylococcus aureus is one of the most dreaded pathogens worldwide and emergence of notorious antibiotic resistant strains have further exacerbated the present scenario. The glycolytic enzyme, triosephosphate isomerase (TIM) is one of the cell envelope proteins of the coccus and is involved in biofilm formation. It ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2012.07.001
更新日期:2012-12-01 00:00:00
abstract::Oligonucleotides that complement Escherichia coli 16S ribosomal RNA residues 685-696 and 694-705 have been synthesized so as to incorporate antibody-recognizable markers: a 3'-terminal residue of N6-delta 2-isopentenyladenosine, a 5'-dinitrophenyl group, or both. Each oligonucleotide is able to bind RNA within the sma...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/0300-9084(91)90132-k
更新日期:1991-07-01 00:00:00
abstract::The SOS response can be induced indirectly in Escherichia coli by infection with UV irradiated bacteriophage P1, lambda or M13. Induction, monitored quantitatively by means of a sfiA::lac operon fusion, was stronger with the plasmid phage P1 than with lambda, but the kinetics were similar, showing that plasmid and non...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/s0300-9084(82)80100-4
更新日期:1982-08-01 00:00:00
abstract::Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown adipose tissues. The accumulating evidence confirms the presence of active brown adipocytes, not onl...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2017.04.017
更新日期:2017-07-01 00:00:00
abstract::Pseudouridine [Ψ] is a frequent base modification in the ribosomal RNA [rRNA] and may be involved in the modulation of the conformational flexibility of rRNA helix-loop structures during protein synthesis. Helix 69 of 23S rRNA contains pseudouridines at the positions 1911, 1915 and 1917 which are formed by the helix 6...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2010.12.018
更新日期:2011-05-01 00:00:00
abstract::In the recent years, we have provided evidence that Tumor Protein 53-Induced Nuclear Protein 1 (TP53INP1) is a key stress protein with antioxidant-associated tumor suppressive function. The TP53INP1 gene, which is highly conserved in mammals, is over-expressed during stress responses including inflammation. This gene ...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2015.07.024
更新日期:2015-11-01 00:00:00
abstract::The Cystic Fibrosis Transmembrane Regulator (CFTR) is a membrane protein whose mutations cause cystic fibrosis, a lethal genetic disease. We performed a molecular dynamic (MD) study of the properties of the nucleotide binding domains (NBD) whose conformational changes, upon ATP binding, are the direct responsible of t...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2015.01.010
更新日期:2015-04-01 00:00:00
abstract::Theoretic and experimental arguments are surveyed which justify the setting up, within the family of pyridoxal-P-dependent lyases, of a special subgroup that comprizes several enzymes catalyzing exclusively beta-replacement reactions of alpha-aminoacids with electronegative substituents in the beta-position. The autho...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/s0300-9084(76)80351-3
更新日期:1976-01-01 00:00:00
abstract::Experimental evidence accumulated to date by several research groups indicates that antisense oligodeoxynucleotides targeted against messenger RNA (mRNA) sequences located downstream of the initiation codon fail to inhibit the translation of this mRNA unless the hybrid is cleaved by RNase H. It has previously been sho...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/0300-9084(93)90032-n
更新日期:1993-01-01 00:00:00
abstract::Evidence shows that oral glycerol supplementation during the early stages of rat liver cancer reduces the growth of preneoplastic lesions. Besides, human hepatocellular carcinoma (HCC) cells display decreased expression of glycerol channel aquaporin 9 (AQP9) and also diminished glycerol-3-phosphate (G3P) content. Acco...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.01.002
更新日期:2020-03-01 00:00:00
abstract::Seven virulent bacteriophages of Streptococcus thermophilus were characterized at the molecular level and classified into 2 subgroups (A and B) by DNA/DNA hybridization experiments and analysis of their structural proteins. Two representatives of subgroups A and B were compared to 3 representatives of Neve's subgroups...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/0300-9084(90)90002-x
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:Fatty acids (FAs), and especially monounsaturated FAs (MUFAs) stimulate GLP-1 release. However, lipotoxicity is indicated in GLP-1 secreting cells following long-term exposure to elevated levels of saturated FAs (SFAs) in vivo and in vitro, where in vitro studies indicate that cosupplementation with MUFAs co...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2018.11.017
更新日期:2019-04-01 00:00:00
abstract::Structural and motional features in the denatured state of a protein dictate the early folding events starting from that state and these features vary depending upon the nature of the denaturant used. Here, we have attempted to decipher the early events in the folding of Dynein Light Chain protein (DLC8), starting fro...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2011.10.013
更新日期:2012-01-01 00:00:00
abstract::The molecular basis for the essential role of cholesterol in mammalian (and other cholesterol-requiring) cells has long been the object of intense interest. Cholesterol has been found to modulate the function of membrane proteins critical to cellular function. Current literature supports two mechanisms for this modula...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/0300-9084(91)90093-g
更新日期:1991-10-01 00:00:00
abstract::Kissing loop interactions (KLIs) are a common motif that is critical in retroviral dimerization, viroid replication, mRNA, and riboswitches. In addition, KLIs are currently used in a variety of biotechnology applications, such as in aptamer sensors, RNA scaffolds and to stabilize vaccines for therapeutics. Here we des...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2018.11.012
更新日期:2019-02-01 00:00:00
abstract::The class I glutamine (Gln) tRNA synthetase interacts with the anticodon and acceptor stem of glutamine tRNA. RNA hairpin helices were designed to probe acceptor stem and anticodon stem-loop contacts. A seven-base pair RNA microhelix derived from the acceptor stem of tRNA(Gln) was aminoacylated by Gln tRNA synthetase....
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/0300-9084(93)90003-b
更新日期:1993-01-01 00:00:00
abstract::Sialidase catalyzes the removal of sialic acids from glycoconjugates. Recently, medaka sialidase Neu1 has been cloned and its enzymatic properties were investigated. Although enzymatic properties of this sialidase, such as optimal pH and substrate specificity, exhibits high similarity with human NEU1, Neu1 physiologic...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2017.01.008
更新日期:2017-04-01 00:00:00
abstract::The lipoprotein complex from human gallbladder bile was challenged with anti-IgA and anti-IgG antisera in order to determine whether the apolipoprotein complex isolated from the detergent-free form of bile lipoprotein contains IgA and IgG. The apolipoprotein complex indeed crossreacts with anti-IgA and anti-IgG. In ad...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/s0300-9084(81)80033-8
更新日期:1981-10-01 00:00:00
abstract::Phosphorus metabolites and intracellular pH have been examined in the slime mold Dictyostelium discoideum by non-destructive 31P-NMR measurements. In a spectrum from a suspension of aerobic amoebae, the major peaks are inorganic phosphate, nucleotide di- and triphosphates. In the corresponding perchloric acid extract,...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/s0300-9084(86)80077-3
更新日期:1986-12-01 00:00:00
abstract::Over the past 200 years emissions of toxic heavy metals have risen tremendously and significantly exceed those from natural sources for practically all metals. Uptake and accumulation by crop plants represents the main entry pathway for potentially health-threatening toxic metals into human and animal food. Of major c...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2006.07.003
更新日期:2006-11-01 00:00:00
abstract::The binding of Ca2+ to membrane models composed of diplamitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) 15N-labeled in the polar head group was investigated at pH 8.5 and pH 9.4 by 15N-NMR spectroscopy. Both phospholipids exhibit a decrease in the chemical shift anisotropy, indicating c...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/0300-9084(89)90143-0
更新日期:1989-01-01 00:00:00
abstract::The microbial resistance to antibiotics is a genuine global threat. Consequently, a search of new inhibitors remains of acute importance due to the increasing spread of multidrug resistance. Here we present a new type of non-β-lactam β-lactamase inhibitor PA-34 based on natural phenoxyaniline, identified using compute...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2016.10.011
更新日期:2017-01-01 00:00:00
abstract::Binding of indoloquinolines with different aliphatic side chains to a parallel G-quadruplex derived from the MYC promoter sequence was characterized by optical and calorimetric measurements. ITC experiments performed at different temperatures enabled the determination of molar heat capacity changes upon quadruplex bin...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2018.11.015
更新日期:2019-02-01 00:00:00