Brown and brite adipocytes: Same function, but different origin and response.


:Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown adipose tissues. The accumulating evidence confirms the presence of active brown adipocytes, not only in newborns, but also in adult humans. In rodents, there are two populations of the Ucp1-expressing adipocytes with well characterized-thermogenic functions, classical interscapular brown adipocytes and brite/beige adipocytes (brown adipocytes that are induced in white adipose tissues). Importantly, the anatomical localization, gene expression profiling and functional characterization of Ucp1-expressing fat cells indicates brite and brown adipocytes coexist in human beings. Therefore, the research directions of brown and brite adipogenesis provide lead to potential new therapies to fight obesity and its related metabolic diseases in human being. The objectives of this review are (1) to discuss the fate of primary adipocytes based on tissue origins, and (2) to discuss mechanisms of brown and brite adipogenesis which could lead to their different responses to browning reagents.






Chu DT,Gawronska-Kozak B




Has Abstract


2017-07-01 00:00:00












  • Structure and organization of ribosomal DNA.

    abstract::Three trends are seen in the organization of ribosomal DNA genes during evolution: 1) gradual separation and separability of the regulation of transcription of 5S and larger subunit rRNAs; 2) retention of a transcription unit containing both large and small rRNAs; and 3) clustering of genes for both 5S and 18S-28S rDN...


    pub_type: 杂志文章,评审


    authors: Srivastava AK,Schlessinger D

    更新日期:1991-06-01 00:00:00

  • Hormone-mediated inositol lipid breakdown in hepatocytes and WRK1 cells: relationship to receptor function.

    abstract::All hormones and neurotransmitters which provoke their intracellular effects by increasing the cytosolic concentration of Ca2+ in their target cells also stimulate the breakdown of inositol phospholipids. Much evidence suggests that this breakdown is intimately involved in the mechanism which couples cell-surface rece...


    pub_type: 杂志文章,评审


    authors: Kirk CJ,Guillon G,Balestre MN,Creba JA,Michell RH,Jard S

    更新日期:1985-10-01 00:00:00

  • Protective cellular immunity against P. falciparum malaria merozoites is associated with a different P7 and P8 residue orientation in the MHC-peptide-TCR complex.

    abstract::Developing a logical and rational methodology for obtaining vaccines, especially against the main parasite causing human malaria (P. falciparum), consists of blocking receptor-ligand interactions. Conserved peptides derived from proteins involved in invasion and having high red blood cell binding ability have thus bee...


    pub_type: 杂志文章


    authors: Patarroyo ME,Salazar LM,Cifuentes G,Lozano JM,Delgado G,Rivera Z,Rosas J,Vargas LE

    更新日期:2006-02-01 00:00:00

  • Epigenetics in asthma and COPD.

    abstract::Epigenetic mechanisms are likely to play a role in many complex diseases, the extent of which we only beginning to understand. COPD and asthma are two respiratory diseases subject to strong environmental influences depending on underlying genetic susceptibility. Epigenetic mechanisms such as DNA methylation, histone m...


    pub_type: 杂志文章,评审


    authors: Kabesch M,Adcock IM

    更新日期:2012-11-01 00:00:00

  • Expression of the bovine hypothalamic hormone oxytocin precursor in Escherichia coli.

    abstract::The bovine oxytocin precursor was expressed in Escherichia coli as a fusion protein by cloning the hormone encoding cDNA in frame behind the replicase gene of the RNA phage MS2. By step-wise extraction with different urea concentrations, the fusion protein was enriched in the 7 M urea fraction and further purified by ...


    pub_type: 杂志文章


    authors: Nörenberg U,Brunath A,Richter D

    更新日期:1988-01-01 00:00:00

  • Implication of liver cardiolipins in mitochondrial energy metabolism disorder in cancer cachexia.

    abstract::Mitochondrial membranes are essential for the good functioning of the organelle. For instance, the inner mitochondrial membrane contains the oxidative phosphorylation system that permits ATP synthesis. Phospholipids environment and especially cardiolipin are crucial for the mitochondrial energy metabolism. Indeed, car...


    pub_type: 杂志文章,评审


    authors: Dumas JF,Peyta L,Couet C,Servais S

    更新日期:2013-01-01 00:00:00

  • Expression of the MuIFN alpha 7 gene in Bacillus subtilis using the levansucrase system.

    abstract::The mouse interferon alpha 7 gene, the signal sequence of which has been removed by oligonucleotide-directed mutagenesis, was introduced into a Bacillus subtilis secretion vector containing the promoter and the signal sequence of the B. subtilis levansucrase gene. Different B. subtilis strains were transformed with th...


    pub_type: 杂志文章


    authors: Dion M,Rapoport G,Doly J

    更新日期:1989-06-01 00:00:00

  • Thiolation of low-density lipoproteins and their interaction with L2C leukemic lymphocytes.

    abstract::We present here, a new method for coupling sulfhydryl groups (SH) to low-density lipoprotein (LDL) surface. This method uses homocysteine thiolactone (HCTL) which reacts with lysine residues in a very mild manner, and permits the selection of the number of SH bound per LDL. Under our experimental conditions (8 SH/LDL)...


    pub_type: 杂志文章


    authors: Vidal M,Sainte-Marie J,Philippot J,Bienvenue A

    更新日期:1986-05-01 00:00:00

  • Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes.

    abstract::Over the last decades, mesenchymal stem cells (MSCs) have been extensively studied with regard to their potential applications in regenerative medicine. In rheumatic diseases, MSC-based therapy is the subject of great expectations for patients who are refractory to proposed treatments such as rheumatoid arthritis (RA)...


    pub_type: 杂志文章,评审


    authors: Maumus M,Jorgensen C,Noël D

    更新日期:2013-12-01 00:00:00

  • Methylation process of mammalian ribosomal precursor RNA.

    abstract::The analysis of RNA from L5178 Y cells, by electrophoreis in 1.7% polyacrylamide gel, after short time labelling with [methyl-3H] methionine, shows that the three molecular species 47S, 46S and 45S RNA from the ribosomal RNA "45S fraction" are methylated. Comparative studies of the kinetics obtained after labelling fo...


    pub_type: 杂志文章


    authors: Tiollais P,Auger MA,Galibert F

    更新日期:1975-11-01 00:00:00

  • Evidence for a phosphoenolpyruvate dependent sugar-phosphotransferase system in the mollicute Acholeplasma florum.

    abstract::In order to confirm the presence of a phosphoenolpyruvate (PEP)-dependent sugar-phosphotransferase system (PTS) in the mollicute Acholeplasma florum we studied the ability of cell free extracts of this organism to phosphorylate glucose and/or fructose in the presence of PEP. We also cloned and sequenced a DNA fragment...


    pub_type: 杂志文章


    authors: Navas-Castillo J,Laigret F,Hocquellet A,Chang CJ,Bove JM

    更新日期:1993-01-01 00:00:00

  • Oxidative phosphorylation in intact chl-r mutants of Escherichia coli K 12.

    abstract::The efficiency of oxidative phosphorylation was estimated in intact resting cells of Escherichia coli K 12, strain PA 601 (chl-s) and its chl-r mutants, all of them grown anaerobically in the presence of nitrate. The oxidation of endogenous NADH in intact chl-s cells was accompanied by the formation of ATP whatever th...


    pub_type: 杂志文章


    authors: Giordano G,Rivière C,Azoulay E

    更新日期:1977-01-01 00:00:00

  • [Purification and characterization of an extracellular protease from Staphylococcus aureus inhibited by EDTA].

    abstract::A neutral protease, produced by Staphylococcus aureus, strain V8, was purified by precipitation with ammonium sulfate and acetone, and by chromatography on D.E.A.E.-cellulose. The purified protein is homogeneous by acrylamide gel electrophoresis. The molecular weight of the enzyme is estimated to be 28.000 daltons by ...


    pub_type: 杂志文章


    authors: Saheb SA

    更新日期:1976-01-01 00:00:00

  • Calcium and spermine interaction with phospholipid bilayers: a 15N NMR study.

    abstract::The binding of Ca2+ to membrane models composed of diplamitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) 15N-labeled in the polar head group was investigated at pH 8.5 and pH 9.4 by 15N-NMR spectroscopy. Both phospholipids exhibit a decrease in the chemical shift anisotropy, indicating c...


    pub_type: 杂志文章


    authors: Akoka S,Tellier C

    更新日期:1989-01-01 00:00:00

  • Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins.

    abstract::The Rap family of small GTP-binding proteins is composed by four different members: Rap1A, Rap1B, Rap2A and Rap2B. In this work we report the identification and characterization of a fifth member of this family of small GTPases. This new protein is highly homologous to Rap2A and Rap2B, binds labeled GTP on nitrocellul...


    pub_type: 杂志文章


    authors: Paganini S,Guidetti GF,Catricalà S,Trionfini P,Panelli S,Balduini C,Torti M

    更新日期:2006-03-01 00:00:00

  • [Role of lipids in the function of microsomal electron transport chains of potato].

    abstract::Microsomal membranes from potato tubers were extracted by acetone solutions of increasing concentrations (5, 10, 15, 20, 30, 40, 50, 70 and 90 p. cent). Microsomal lipids were progressively extracted: acetone concentrations exceeding 30 p. cent extracted large amounts of membraneous phospholipids (figure). Lipid extra...


    pub_type: 杂志文章


    authors: Jolliot A,Demandre C,Mazliak P

    更新日期:1978-01-01 00:00:00

  • In vitro synthesis of simian virus 40 DNA. I. Synthesis by a soluble extract from infected CV1 cells.

    abstract::Simian Virus 40 (SV40) DNA replication was studied in vitro using cell free extracts prepared from SV40 infected CV1 cells. The cells were fractionated into a soluble cytoplasmic fraction and nuclei. The nuclei were lysed with high salt and used to prepare a soluble nuclear fraction. Both fractions displayed DNA polym...


    pub_type: 杂志文章


    authors: Girard M,Marty L,Cajean C,Suarez F

    更新日期:1976-11-13 00:00:00

  • Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B.

    abstract::The quest for effective anticancer therapeutics continues to be extensively pursued. Over the past century, several drugs have been developed, however, a majority of these drugs have a poor therapeutic index and increased toxicity profile. Hence, there still exists ample opportunity to discover safe and effective anti...


    pub_type: 杂志文章


    authors: Singh M,Malhotra L,Haque MA,Kumar M,Tikhomirov A,Litvinova V,Korolev AM,Ethayathulla AS,Das U,Shchekotikhin AE,Kaur P

    更新日期:2021-01-06 00:00:00

  • 27-hydroxycholesterol decreases cell proliferation in colon cancer cell lines.

    abstract::Colorectal cancer (CRC) is the third most diagnosed cancer in the western world, affecting 1 out of approximately 22 people in their lifetime. Several epidemiological studies suggest a positive association between high plasma cholesterol levels and colorectal cancer. However, the molecular mechanisms by which choleste...


    pub_type: 杂志文章


    authors: Warns J,Marwarha G,Freking N,Ghribi O

    更新日期:2018-10-01 00:00:00

  • From green chemistry to nature: The versatile role of low transition temperature mixtures.

    abstract::In 1998, the concept of "green chemistry" was established through twelve principles with the aim of improving the eco-efficiency of chemical processes and to judge, whether or not, a chemical process is sustainable. Currently, numerous processes do not obey to most of these principles (large energy usage, formation of...


    pub_type: 杂志文章,评审


    authors: Durand E,Lecomte J,Villeneuve P

    更新日期:2016-01-01 00:00:00

  • Potential secondary structure at the translational start domain of eukaryotic and prokaryotic mRNAs.

    abstract::In order to identify conserved potential secondary structures within translational start sites, mRNA sequences derived from different species were studied with programs able to depict such features. The potential secondary structure of 71 bases around the initiator AUG or AUGs in the coding sequences of 290 eukaryotic...


    pub_type: 杂志文章


    authors: Ganoza MC,Louis BG

    更新日期:1994-01-01 00:00:00

  • A new bacterial dehydrogenase oxidizing the lignin model compound guaiacylglycerol beta-O-4-guaiacyl ether.

    abstract::A lignin model compound, named in short guaiagylglycerol beta-guaiacyl ether (GGE), contains the beta-0-4 ether linkage that is common in the chemical structure of lignin. A Pseudomonas sp. (GU5) had been isolated as an organism able to grow with GGE as the sole source of carbon and energy. When grown on vanillate, th...


    pub_type: 杂志文章


    authors: Pelmont J,Barrelle M,Hauteville M,Gamba D,Romdhane M,Dardas A,Beguin C

    更新日期:1985-09-01 00:00:00

  • Comparison of the invasion strategies used by Salmonella cholerae-suis, Shigella flexneri and Yersinia enterocolitica to enter cultured animal cells: endosome acidification is not required for bacterial invasion or intracellular replication.

    abstract::Strains of Escherichia, Salmonella, Shigella and Yersinia actively enter eukaryotic cells. Several techniques were used to compare and contrast the invasion mechanisms of Salmonella cholerae-suis, Yersinia enterocolitica and Shigella flexneri. Three animal cell lines (CHO, HEp-2 and MDCK) were examined for susceptibil...


    pub_type: 杂志文章


    authors: Finlay BB,Falkow S

    更新日期:1988-08-01 00:00:00

  • lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference.

    abstract::Long non-coding RNAs constitute the most abundant part of the transcribed mammalian genome. lncRNAs affect all essential processes in the living cell including transcription, splicing, translation, replication, shaping of chromatin and post translational modification of proteins. Alterations in lncRNA expression have ...


    pub_type: 杂志文章,评审


    authors: Smekalova EM,Kotelevtsev YV,Leboeuf D,Shcherbinina EY,Fefilova AS,Zatsepin TS,Koteliansky V

    更新日期:2016-12-01 00:00:00

  • Targeting human Rad51 by specific DNA aptamers induces inhibition of homologous recombination.

    abstract::Human Rad51 (HsRad51), a key element of the homologous recombination repair pathway, is related to the resistance of cancer cells to chemo- and radio-therapies. This protein is thus a good target for the development of anti-cancer treatments. We have searched for new inhibitors directed against HsRad51 using the Syste...


    pub_type: 杂志文章


    authors: Martinez SF,Renodon-Cornière A,Nomme J,Eveillard D,Fleury F,Takahashi M,Weigel P

    更新日期:2010-12-01 00:00:00

  • Toxicity, binding and internalization of the pea-A1b entomotoxin in Sf9 cells.

    abstract::PA1b (Pea Albumin 1b) is a peptide toxin lethal for certain insects. This paper shows that the cultured insect cells Sf9 are sensitive to the toxin and display a high-affinity binding site for PA1b. Mammalian cells are not sensitive and no binding activity was detected. Signs of apoptosis of the Sf9 cells were observe...


    pub_type: 杂志文章


    authors: Rahioui I,Laugier C,Balmand S,Da Silva P,Rahbe Y,Gressent F

    更新日期:2007-12-01 00:00:00

  • Improved stability and yield of Fv targeted superantigen by introducing both linker and disulfide bond into the targeting moiety.

    abstract::Bacterial superantigens (SAg) are the most potent activators of human T lymphocytes and recombinant immunotoxin using bacterial SAg shows promising clinical values. To engineer superantigen for immunotherapy of hepatocellular carcinoma, we genetically fused the superantigen staphylococcus enterotoxin A (SEA(D(227)A)) ...


    pub_type: 杂志文章


    authors: Hao HJ,Jiang YQ,Zheng YL,Ma R,Yu DW

    更新日期:2005-08-01 00:00:00

  • Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa.

    abstract::The mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-proteobacterium with a methane-producing archae. The main function of the canonical aerobic mitochondria include ATP generation via oxidative phosphorylation, heme and phospholipid synthesis, calcium homeostasis, programmed cell death, an...


    pub_type: 杂志文章,评审


    authors: Makiuchi T,Nozaki T

    更新日期:2014-05-01 00:00:00

  • The influence of adenosine on intermediary metabolism of isolated hepatocytes.

    abstract::The effect of adenosine was tested on the energetic metabolism of fed rat liver cells after isolation. The cells were incubated in a buffered saline medium with glucose (5 mM) and adenosine (1 mM) for 30 minutes at 37 degrees C. This increased the concentration of the adenylic nucleotides ATP (+57 per cent, ADP (+39 p...


    pub_type: 杂志文章


    authors: Marchand JC,Lavoinne A,Giroz M,Matray F

    更新日期:1979-01-01 00:00:00

  • Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models.

    abstract::Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin H(2) (PGH(2)) to PGE(2), is known to comprise a group of at least three structurally and biologically distinct enzymes. Two of them are membrane-bound and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear pro...


    pub_type: 杂志文章,评审


    authors: Hara S,Kamei D,Sasaki Y,Tanemoto A,Nakatani Y,Murakami M

    更新日期:2010-06-01 00:00:00