Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants.

abstract：:The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against wide-range pathogens. The effectiveness of IFN to control initial infection requires the cooperation between several pathways induced in the target cells. Rece...

journal_title：Biochimie

authors： Degols G,Eldin P,Mechti N

更新日期：2007-06-01 00:00:00

abstract：:Single cell oils (SCOs) are now produced by various microorganisms as commercial sources of arachidonic acid (ARA) and docosahexaenoic acid (DHA). These oils are now used extensively as dietary supplements in infant formulas. An understanding of the underlying biochemistry and genetics of oil accumulation in such micr...

journal_title：Biochimie

authors： Ratledge C

更新日期：2004-11-01 00:00:00

abstract：:A neoglycolipid of structure beta-D-Glcp-S-(CH2)3N(OH)(CH2)4-O-cholest-5-en-3 beta-yl has been prepared in fair overall yield by reduction of the nitrone obtained by condensation of beta-D-Glcp-S-(CH2)3NHOH and OCH-(CH2)3-O-cholest-5-en-3 beta-yl. This synthetic procedure is very flexible, allowing a large range of le...

journal_title：Biochimie

authors： Tronchet JM,Zsély M,Ricca A,Barbalat-Rey F,Geoffroy M

更新日期：1992-01-01 00:00:00

abstract：:The structure of ATP synthase subunit 4 was determined by using the oligonucleotide probe procedure. This subunit is the fourth polypeptide of the complex when classifying subunits in order of decreasing molecular mass. Its relative molecular mass is 25 kDa. The ATP4 gene was isolated and sequenced. The nucleotide seq...

journal_title：Biochimie

authors： Velours J,Arselin G,Paul MF,Galante M,Durrens P,Aigle M,Guerin B

更新日期：1989-08-01 00:00:00

abstract：:The mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-proteobacterium with a methane-producing archae. The main function of the canonical aerobic mitochondria include ATP generation via oxidative phosphorylation, heme and phospholipid synthesis, calcium homeostasis, programmed cell death, an...

journal_title：Biochimie

authors： Makiuchi T,Nozaki T

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:We evaluated the clinical relevance of microRNA-149 (miR-149) in neuroblastoma (NB) and its functional roles in regulating NB proliferation in vitro. METHODS:QRT-PCR was used to evaluate miR-149 expression in NB cell lines and primary NB tumors. Association between endogenous miR-149 expression in primary NB t...

journal_title：Biochimie

authors： Xu Y,Chen X,Lin L,Chen H,Yu S,Li D

更新日期：2017-08-01 00:00:00

abstract：:Pentatricopeptide repeat (PPR) proteins are a large family of modular RNA-binding proteins which mediate several aspects of gene expression primarily in organelles but also in the nucleus. These proteins facilitate processing, splicing, editing, stability and translation of RNAs. While major advances in PPR research h...

journal_title：Biochimie

authors： Manna S

更新日期：2015-06-01 00:00:00

abstract：:The quest for effective anticancer therapeutics continues to be extensively pursued. Over the past century, several drugs have been developed, however, a majority of these drugs have a poor therapeutic index and increased toxicity profile. Hence, there still exists ample opportunity to discover safe and effective anti...

journal_title：Biochimie

authors： Singh M,Malhotra L,Haque MA,Kumar M,Tikhomirov A,Litvinova V,Korolev AM,Ethayathulla AS,Das U,Shchekotikhin AE,Kaur P

更新日期：2021-01-06 00:00:00

abstract：:Ten new defensins have been isolated from seeds of Triticum kiharae and related species of the Triticum and Aegilops genera by a combination of chromatographic procedures including affinity-, size-exclusion, and reversed-phase high-performance liquid chromatography. Nine were completely sequenced and shown to represen...

journal_title：Biochimie

authors： Odintsova TI,Egorov TA,Musolyamov AKh,Odintsova MS,Pukhalsky VA,Grishin EV

更新日期：2007-05-01 00:00:00

abstract：:Numerous studies have reported the beneficial effects of antioxidants in human diseases. Among their biological effects, a majority of antioxidants scavenge reactive radicals in the body, thereby reducing oxidative stress that is associated with the pathogenesis of many diseases. Antioxidant dendrimers are a new class...

journal_title：Biochimie

authors： Lee CY,Nanah CN,Held RA,Clark AR,Huynh UG,Maraskine MC,Uzarski RL,McCracken J,Sharma A

更新日期：2015-04-01 00:00:00

abstract：:A synthetic phosphonate inhibitor designed for lipase inhibition but displaying a broader range of activity was covalently immobilized on a solid support to generate a function-directed tool targeting serine hydrolases. To achieve this goal, straightforward and reliable analytical techniques were developed, allowing t...

journal_title：Biochimie

authors： Delorme V,Raux B,Puppo R,Leclaire J,Cavalier JF,Marc S,Kamarajugadda PK,Buono G,Fotiadu F,Canaan S,Carrière F

更新日期：2014-12-01 00:00:00

abstract：:This paper provides an overview of the usefulness of the resonance Raman (RR) spectroscopy in the determination of the structural and electronic properties of heme(s) included in c-type cytochromes. It reviews the mode assignments presently available for heme c and includes recent RR data on the most important subclas...

journal_title：Biochimie

authors： Desbois A

更新日期：1994-01-01 00:00:00

abstract：:The hbs operon of Bacillus subtilis comprises a single gene which is localized between the spoIVA and mtrA open reading frames, and is situated at 204 degrees of the standard map of B subtilis. Expression of hbs is initiated from two distinct promoters called P1 and P2. The transcription initiation sites have been map...

journal_title：Biochimie

authors： Micka B,Marahiel MA

更新日期：1992-07-01 00:00:00

abstract：:Theoretic and experimental arguments are surveyed which justify the setting up, within the family of pyridoxal-P-dependent lyases, of a special subgroup that comprizes several enzymes catalyzing exclusively beta-replacement reactions of alpha-aminoacids with electronegative substituents in the beta-position. The autho...

journal_title：Biochimie

authors： Braunstein AE,Goryachenkova EV

更新日期：1976-01-01 00:00:00

abstract：:Innate immune system is the first line of host defense against invading microorganisms. It relies on a limited number of germline-encoded pattern recognition receptors that recognize conserved molecular structures of microbes, referred to as pathogen-/microbe-associated molecular patterns (PAMPs/MAMPs). Bacterial cell...

journal_title：Biochimie

authors： Ray A,Cot M,Puzo G,Gilleron M,Nigou J

更新日期：2013-01-01 00:00:00

abstract：:The widespread nature of protein phosphorylation/dephosphorylation underscores its key role in cell signaling metabolism, growth and differentiation. Tyrosine phosphorylation of cytoplasmic proteins is a critical event in the regulation of intracellular signaling pathways activated by external stimuli. An adequate bal...

journal_title：Biochimie

authors： Zambuzzi WF,Milani R,Teti A

更新日期：2010-04-01 00:00:00

abstract：:Long term cadmium (Cd) exposure in occupational and general environments may give rise to kidney dysfunction. This effect is usually considered to be the critical effect, i. e. the effect that occurs at relatively low level of exposure. The present review focused on studies of the prevalence of cadmium-related kidney ...

journal_title：Biochimie

authors： Nordberg GF,Jin T,Wu X,Lu J,Chen L,Lei L,Hong F,Nordberg M

更新日期：2009-10-01 00:00:00

abstract：:Analysis of the nucleotide sequence of 1,400 transfer RNAs has revealed the imprint of a prototypic genetic code in position 3-4-5 of the acceptor stem. It appears only in the transfer RNAs for the primordial amino acids ie those found by chemical condensation of a nitrogen-methane-water-ammonia mixture. The model for...

journal_title：Biochimie

authors： Möller W,Janssen GM

更新日期：1990-05-01 00:00:00

abstract：:Polysialylated neural cell adhesion molecule (NCAM) was immunoaffinity-purified from the brains of newborn calves. A degree of polymerization of up to 40 was chromatographically determined for released polysialic acid (PSA) chains. For characterization of N-glycan structures and attachment sites, PSA-NCAM was digested...

journal_title：Biochimie

authors： Wuhrer M,Geyer H,von der Ohe M,Gerardy-Schahn R,Schachner M,Geyer R

更新日期：2003-01-01 00:00:00

abstract：:In the recent years, we have provided evidence that Tumor Protein 53-Induced Nuclear Protein 1 (TP53INP1) is a key stress protein with antioxidant-associated tumor suppressive function. The TP53INP1 gene, which is highly conserved in mammals, is over-expressed during stress responses including inflammation. This gene ...

journal_title：Biochimie

authors： Saadi H,Seillier M,Carrier A

更新日期：2015-11-01 00:00:00

abstract：:Lysosomal cysteine proteinases were fractionated from partially purified rat muscle lysosomes. By gel filtration on Sephadex G75, cathepsin D was separated from two thiol-requiring proteolytic fractions of Mr 25 000 and 55 000, respectively. By chromatofocusing, the first fraction (Mr = 25 000) was resolved into three...

journal_title：Biochimie

authors： Obled A,Ouali A,Valin C

更新日期：1984-09-01 00:00:00

abstract：:A major incentive in inhibitor research is that control of limited proteolysis constitutes a valuable pharmacological tool. Protease inhibitors have proved to be successful in influencing pathogenesis in many experimental models but a breakthrough to use in human therapy has mainly been restricted to aprotinin and ang...

journal_title：Biochimie

authors： Scharpe S,De Meester I,Hendriks D,Vanhoof G,van Sande M,Vriend G

更新日期：1991-01-01 00:00:00

abstract：:Recently we have found that cytokine IL-2 and innate immunity protein Tag7 activate cytotoxic lymphocytes that kill HLA-negative tumor cells, inducing both apoptosis and necroptosis. Here we decrypt the processes, taking part in necroptosis execution after FasL-Fas interaction. Necroptosis begins with RIPK1 activation...

journal_title：Biochimie

authors： Sharapova TN,Romanova EA,Sashchenko LP,Yashin DV

更新日期：2018-09-01 00:00:00

abstract：:Acinetobacter baumannii encodes all enzymes required in the tricarboxylic acid (TCA) cycle and glyoxylate bypass except for isocitrate dehydrogenase kinase/phosphatase (IDHKP), which can phosphorylate isocitrate dehydrogenase (IDH) at a substrate-binding Ser site and control the carbon flux in enterobacteria, such as ...

journal_title：Biochimie

authors： Song P,Wang ML,Zheng QY,Wang P,Zhu GP

更新日期：2020-12-05 00:00:00

abstract：:Unlike most tonoplast ATPases, the vacuolar ATPase of Acer pseudoplatanus cells (Km = 0.4 mM) was strongly inhibited by vanadate (I50 = 10 microM). The inhibition was non-competitive. Chemicals usually added in the reaction mixture either increase (NH+4, K+) or decrease (Na+, EDTA) the ATPase inhibition. However, thes...

journal_title：Biochimie

authors： Montrichard F,Pugin A,Gaudemer Y

更新日期：1989-07-01 00:00:00

abstract：:Thorium-232 ((232)Th), a natural radionuclide from the actinide family, is abundantly present in monazite and other ores. It is used as one of the prime fuel materials in nuclear industry and may pose an exposure risk to nuclear workers and members of the public. Human erythrocytes, as a classical cellular membrane mo...

journal_title：Biochimie

authors： Kumar A,Ali M,Pandey BN,Hassan PA,Mishra KP

更新日期：2010-07-01 00:00:00

abstract：:The specific binding of the amyloid protein precursor (APP) to glycosaminoglycans (GAG) suggests that APP is a cell adhesion molecule (CAM) and/or substrate adhesion molecule (SAM). In order to characterize this activity of APP in the brain at the molecular level, we have purified and characterized the major APP speci...

journal_title：Biochimie

authors： Multhaup G

更新日期：1994-01-01 00:00:00

abstract：:Influenza virus-associated RNA polymerase is composed of one molecule each of three viral P proteins and carries the complete activity of capped RNA-primed vRNA-directed transcription. The RNA polymerase holoenzyme also carries capped RNA endonuclease to generate capped oligonucleotide primers for transcription and 3'...

journal_title：Biochimie

authors： Ishihama A

更新日期：1996-01-01 00:00:00

abstract：:Nanoluciferase (NanoLuc) is a newly developed small luciferase reporter with the brightest bioluminescence reported to date. In the present work, we developed NanoLuc as a novel quantitative protein fusion tag for efficient overexpression in Escherichia coli and ultrasensitive bioluminescent assays using human leukemi...

journal_title：Biochimie

authors： He SX,Song G,Shi JP,Guo YQ,Guo ZY

更新日期：2014-11-01 00:00:00

abstract：:Recombinant plasmids containing head-to-tail copies of different coat-protein replacement genomes of wheat dwarf virus (WDV) were used to study the mechanism leading to the release of replicating unit-length molecules in suspension culture cells of Triticum monococcum. For plasmids bearing two complete genomes, the vi...

journal_title：Biochimie

authors： Heyraud F,Matzeit V,Schaefer S,Schell J,Gronenborn B

更新日期：1993-01-01 00:00:00