当前位置： SCI文献检索 > BIOCHIMIE期刊下所有文献 > Effect of electron donating groups on polyphenol-based antioxidant dendrimers.

Effect of electron donating groups on polyphenol-based antioxidant dendrimers.

Abstract：

:Numerous studies have reported the beneficial effects of antioxidants in human diseases. Among their biological effects, a majority of antioxidants scavenge reactive radicals in the body, thereby reducing oxidative stress that is associated with the pathogenesis of many diseases. Antioxidant dendrimers are a new class of potent antioxidant compounds reported recently. In this study, six polyphenol-based antioxidant dendrimers with or without electron donating groups (methoxy group) were synthesized in order to elucidate the influence of electron donating groups (EDG) on their antioxidant activities. Syringaldehyde (2 ortho methoxy groups), vanillin (1 ortho methoxy group), and 4-hydroxybenzaldehyde (0 methoxy group) were derivatized with propargylamine to form building blocks for the dendrimers. All the six dendrimers contain polyether cores, which were synthesized by attaching pentaerythritol and methyl α-d-glucopyranoside to in-house prepared spacer units. To prepare generation 1 antioxidant dendrimers, microwave energy and granulated metallic copper catalyst were used to link the cores and building blocks together via alkyne-azide 1,3-cycloaddition click chemistry. These reaction conditions resulted in high yields of the target dendrimers that were free from copper contamination. Based on DPPH antioxidant assay, antioxidant dendrimers decorated with syringaldehyde and vanillin exhibited over 70- and 170-fold increase in antioxidant activity compared to syringaldehyde and vanillin, respectively. The antioxidant activity of dendrimers increased with increasing number of EDG groups. Similar results were obtained when the dendrimers were used to protect DNA and human LDL against organic carbon and nitrogen-based free radicals. In addition, the antioxidant dendrimers did not show any pro-oxidant activity on DNA in the presence of physiological amounts of copper. Although the dendrimers showed potent antioxidant activities against carbon and nitrogen free radicals, EPR and DNA protection studies revealed lack of effectiveness of these dendrimers against hydroxyl radicals. The dendrimers were not cytotoxic to CHO-K1 cells.

journal_name

Biochimie

journal_title

Biochimie

authors

Lee CY,Nanah CN,Held RA,Clark AR,Huynh UG,Maraskine MC,Uzarski RL,McCracken J,Sharma A

doi

10.1016/j.biochi.2015.02.001

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

125-34

eissn

0300-9084

issn

1638-6183

pii

S0300-9084(15)00028-0

journal_volume

111

pub_type

杂志文章

相关文献

BIOCHIMIE文献大全
  • Poly(ADP-ribose) degradation by post-nuclear extracts from human cells.

    abstract：:The nuclear metabolism of poly(ADP-ribose) is mainly regulated by poly(ADP-ribose) polymerase-1 (PARP-1) and by poly(ADP-ribose) glycohydrolase (PARG). A PARP-like enzyme, V-PARP, and a PARG isoform are present in the extra-nuclear compartment of mammalian cells, even if poly(ADP-ribose) has never been detected therei...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(02)00017-2

    authors： Rossi L,Denegri M,Torti M,Poirier GG,Ivana Scovassi A

    更新日期：2002-12-01 00:00:00

  • [Effect of toyocamycin on the biosynthesis of viral glycoproteins in a cell line chronically infected with a murine retrovirus].

    abstract：:Toyocamycin (TMC), an adenosine analog has been previously reported to inhibit both number and infectivity of retrovirus particles released by chronically infected cells (Bonar et al., 1970; Riman, 1971; Mauchauffé et al., 1979). We have previously shown that loss of infectivity could result from the incorporation of ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(81)80013-2

    authors： Mathieu-Mahul D,Barque JP,Mauchauffe M,Peraudeau L,Larsen CJ

    更新日期：1981-01-01 00:00:00

  • In acute inflammation, the chondroitin-4 sulphate carried by bikunin is not only longer, it is also undersulphated.

    abstract：:Bikunin (Bk) is a Künitz-type serine proteinase inhibitor, which occurs in human plasma, mainly as covalent complexes with one or two of the three peptide heavy chains. The leading member of this glycoprotein family is inter-alpha-inhibitor (I alpha I), which consists of two heavy chains (H1 and H2) linked to Bk. Bk c...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(03)00066-x

    authors： Capon C,Mizon C,Lemoine J,Rodié-Talbère P,Mizon J

    更新日期：2003-01-01 00:00:00

  • Changes in DNA supercoiling in fibroblasts cultured in the presence of hydralazine.

    abstract：:We have analyzed changes in the supercoiling of nucleoid DNA of murine fibroblasts cultured in the presence of hydralazine. The entire DNA attached to the nuclear matrix was extracted from the cells and sedimented in neutral sucrose density gradients containing ethidium bromide. Nucleoids from cells treated with hydra...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(98)80025-4

    authors： Weglarz L,Koceva-Chyła A

    更新日期：1998-07-01 00:00:00

  • A stochastic approach to serotonergic fibers in mental disorders.

    abstract：:Virtually all brain circuits are physically embedded in a three-dimensional matrix of fibers that release 5-hydroxytryptamine (5-HT, serotonin). The density of this matrix varies across brain regions and cortical laminae, and it is altered in some mental disorders, including Major Depressive Disorder and Autism Spectr...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2018.07.014

    authors： Janušonis S,Detering N

    更新日期：2019-06-01 00:00:00

  • 50 years ago: how prepared were our minds?

    abstract：:In 1956, when we started our collaboration, both Alick Isaacs and myself had done previous work on interference between inactive and active influenza viruses. We were aware of the state interference research had reached and of the two alternative explanations that had been envisaged. ...

    journal_title：Biochimie

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.biochi.2007.04.007

    authors： Lindenmann J

    更新日期：2007-06-01 00:00:00

  • ISG20, an actor of the innate immune response.

    abstract：:The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against wide-range pathogens. The effectiveness of IFN to control initial infection requires the cooperation between several pathways induced in the target cells. Rece...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2007.03.006

    authors： Degols G,Eldin P,Mechti N

    更新日期：2007-06-01 00:00:00

  • Identification of proteins crosslinked to RNA in 40S ribosomal subunits of Saccharomyces cerevisiae.

    abstract：:RNA-protein crosslinks were introduced into the 40S ribosomal subunits from Saccharomyces cerevisiae by mild UV treatment. Proteins crosslinked to the 18S rRNA molecule were separated from free proteins by repeated extraction of the treated subunits and centrifugation in glycerol gradients. After digestion with RNase ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/0300-9084(89)90024-2

    authors： Xiang RH,Lee JC

    更新日期：1989-11-01 00:00:00

  • Comparison of solution structure of free and complexed lac operator by molecular modelling with NMR constraints.

    abstract：:The structure difference between the free operator of the lac system d(GCTCACAAT).d(ATTGTGAGC) and the same operator complexed to the headpiece of the lac repressor has been investigated by 2-D-1H NMR spectroscopy in conjunction with molecular modelling in internal coordinates (JUMNA). The free and complexed operator ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/0300-9084(94)90006-x

    authors： Gincel E,Lancelot G,Maurizot JC,Thuong NT,Vovelle F

    更新日期：1994-01-01 00:00:00

  • Isolation and characteristics of mRNPs associated with bound polyribosomes from the ewe lactating mammary gland.

    abstract：:The dissociation of bound polyribosomes from ewe lactating mammary gland, by EDTA or Puromycin-KC1 treatment releases Messenger Ribonucleoprotein particles (mRNP'S) which sediment in sucrose gradients as a single component having a sedimentation coefficient of about 22S. RNAs derived from mRNPs sediment between 9S and...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(76)80439-7

    authors： Assairi L,Gaye P,Houdebine LM

    更新日期：1976-01-01 00:00:00

  • Non-canonical substrates of aminoacyl-tRNA synthetases: the tRNA-like structure of brome mosaic virus genomic RNA.

    abstract：:A 3-D model of the tyrosylable tRNA-like domain of the genomic brome mosaic virus RNAs was built by computer modelling based on solution probing of the molecule with different chemical and enzymatic reagents. This model encompasses four major structural domains, including two peculiar substructures oriented perpendicu...

    journal_title：Biochimie

    pub_type： 杂志文章,评审

    doi：10.1016/0300-9084(93)90014-j

    authors： Felden B,Florentz C,Westhof E,Giegé R

    更新日期：1993-01-01 00:00:00

  • 7β-hydroxycholesterol-induced cell death, oxidative stress, and fatty acid metabolism dysfunctions attenuated with sea urchin egg oil.

    abstract：:Some oxysterols resulting either from enzymatic oxidation or autoxidation of cholesterol are associated with age-related diseases including neurodegenerative diseases. Among these oxysterols, 7β-hydroxycholesterol (7β-OHC) is often found at increased levels in patients. It is therefore important to identify molecules ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2018.06.027

    authors： Zarrouk A,Ben Salem Y,Hafsa J,Sghaier R,Charfeddine B,Limem K,Hammami M,Majdoub H

    更新日期：2018-10-01 00:00:00

  • Biological applications of tethered bilayer lipid membranes.

    abstract：:Lipid membranes have an essential role in most physiological processes including cell protection, cell-to-cell communication and regulation of intracellular signaling. These multiple roles of biological membranes prompted the study and the development of artificial lipid membranes with the primary aim to reconstitute ...

    journal_title：Biochimie

    pub_type： 杂志文章,评审

    doi：10.1016/j.biochi.2018.11.011

    authors： Penkauskas T,Preta G

    更新日期：2019-02-01 00:00:00

  • Thyroglobulin structure and function: recent advances.

    abstract：:Thyroglobulin is a large-size iodoglycoprotein specific to thyroid tissue and is the substrate for the synthesis of thyroid hormones, thyroxine and 3,5,3'-triiodothyronine. Recent studies, which greatly benefited from recombinant DNA methodologies, improved the knowledge of several structural features of this dimeric ...

    journal_title：Biochimie

    pub_type： 杂志文章,评审

    doi：10.1016/0300-9084(89)90057-6

    authors： Malthièry Y,Marriq C,Bergé-Lefranc JL,Franc JL,Henry M,Lejeune PJ,Ruf J,Lissitzky S

    更新日期：1989-02-01 00:00:00

  • Fine tuning gene expression through short DNA-protein binding cycles.

    abstract：:Certain transcription factors have recently been shown to interact with DNA in living cells, through very short binding cycles, contrasting with the data previously obtained in vitro, and with the view of a stepwise building of transcription initiation complexes. These short cycles are triggered by active dissociation...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2009.03.022

    authors： Michel D

    更新日期：2009-07-01 00:00:00

  • Proteins involved in sleep homeostasis: Biophysical characterization of INC and its partners.

    abstract：:The insomniac protein of Drosophila melanogaster (INC) has a crucial role in sleep homeostasis as flies lacking the inc gene exhibit strikingly reduced and poorly consolidated sleep. Nevertheless, in vitro characterizations of INC biophysical properties and partnerships have not been yet reported. Here we report the h...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2016.09.013

    authors： Pirone L,Smaldone G,Esposito C,Balasco N,Petoukhov MV,Spilotros A,Svergun DI,Di Gaetano S,Vitagliano L,Pedone EM

    更新日期：2016-12-01 00:00:00

  • Specificity characterization of the α-mating factor hormone by Kex2 protease.

    abstract：:Kex2 is a Ca2+-dependent serine protease from S. cerevisiae. Characterization of the substrate specificity of Kex2 is of particular interest because this protease serves as the prototype of a large family of eukaryotic subtilisin-related proprotein-processing proteases that cleave sites consisting of pairs or clusters...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2016.10.003

    authors： Manfredi MA,Antunes AA,Jesus LO,Juliano MA,Juliano L,Judice WA

    更新日期：2016-12-01 00:00:00

  • Affinity chromatography of the uterine estradiol receptor on estradiol-PAB-cellulose: an artefact.

    abstract：:Estradiol-PAB-cellulose, an easily prepared adsorbent, has been proposed to purify the uterine estradiol receptor according to the principle of biospecific affinity chromatography. It apparently removes all hormone binding sites when cytosol preparations are incubated with it. A systematic study of this adsorbent was ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(76)80317-3

    authors： Best-Belpomme M,Richard-Foy H,Secco-Millet C,Baulieu EE

    更新日期：1976-01-01 00:00:00

  • Interaction of phosphonates related to glutathione with the rat kidney gamma-glutamylcysteine synthetase.

    abstract：:Various phosphonic and sulfonic glutamate analogues as well as phosphonopeptides related to glutathione were studied for their interaction with rat kidney gamma-glutamylcysteine synthetase activity. We found, in all cases, that the presence of a phosphonic group increases the affinity for the enzyme. Among the tripept...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/0300-9084(87)90083-6

    authors： Marche M,Basurko MJ,Cassaigne A

    更新日期：1987-05-01 00:00:00

  • Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance.

    abstract：:Replication protein A (RPA) is a heterotrimeric single-stranded DNA binding protein whose role in DNA replication, recombination and repair has been mainly elucidated through in vitro biochemical studies utilizing the mammalian complex. However, the identification of homologs of all three subunits in Saccharomyces cer...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(00)00183-8

    authors： Smith J,Zou H,Rothstein R

    更新日期：2000-01-01 00:00:00

  • Exploiting the unique features of Zika and Dengue proteases for inhibitor design.

    abstract：:Zika and Dengue viruses have attracted substantial attention from researchers in light of recent outbreaks of Dengue fever and increases in cases of congenital microcephaly in areas with Zika incidence. This review summarizes the current state of knowledge about Zika and Dengue proteases. These enzymes have several in...

    journal_title：Biochimie

    pub_type： 杂志文章,评审

    doi：10.1016/j.biochi.2019.05.004

    authors： Majerová T,Novotný P,Krýsová E,Konvalinka J

    更新日期：2019-11-01 00:00:00

  • Roles of recA mutant allele (recA495) in frameshift mutagenesis.

    abstract：:The chemical carcinogen N-acetoxy-N-2-acetylaminofluorene (N-AcO-AAF) induces frameshift mutations located within two types of specific sequences (mutation hot spots): i) contiguous guanine sequences and ii) alternating GC sequences. The genetic requirements of these frameshift events were investigated using specific ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/0300-9084(91)90117-j

    authors： Janel-Bintz R,Maenhaut-Michel G,Takahashi M,Fuchs RP

    更新日期：1991-04-01 00:00:00

  • Eukaryotic extracellular catalase-peroxidase from Magnaporthe grisea - Biophysical/chemical characterization of the first representative from a novel phytopathogenic KatG group.

    abstract：:All phytopathogenic fungi have two catalase-peroxidase paralogues located either intracellularly (KatG1) or extracellularly (KatG2). Here, for the first time a secreted bifunctional, homodimeric catalase-peroxidase (KatG2 from the rice blast fungus Magnaporthe grisea) has been produced heterologously with almost 100% ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2011.09.020

    authors： Zámocký M,Droghetti E,Bellei M,Gasselhuber B,Pabst M,Furtmüller PG,Battistuzzi G,Smulevich G,Obinger C

    更新日期：2012-03-01 00:00:00

  • Aptamer affinity ligands in protein chromatography.

    abstract：:The present review deals with the place of single chain oligonucleotide ligands (aptamers) in affinity chromatography applied to proteins. Aptamers are not the only affinity ligands available but they represent an emerging and highly promising route that advantageously competes with antibodies in immunopurification pr...

    journal_title：Biochimie

    pub_type： 杂志文章,评审

    doi：10.1016/j.biochi.2017.10.008

    authors： Perret G,Boschetti E

    更新日期：2018-02-01 00:00:00

  • [Role of lipids in the function of microsomal electron transport chains of potato].

    abstract：:Microsomal membranes from potato tubers were extracted by acetone solutions of increasing concentrations (5, 10, 15, 20, 30, 40, 50, 70 and 90 p. cent). Microsomal lipids were progressively extracted: acetone concentrations exceeding 30 p. cent extracted large amounts of membraneous phospholipids (figure). Lipid extra...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(78)80021-2

    authors： Jolliot A,Demandre C,Mazliak P

    更新日期：1978-01-01 00:00:00

  • Role of protein kinase C in phospholemman mediated regulation of α₂β₁ isozyme of Na⁺/K⁺-ATPase in caveolae of pulmonary artery smooth muscle cells.

    abstract：:We have recently reported that α(2)β(1) and α(1)β(1) isozymes of Na(+)/K(+)-ATPase (NKA) are localized in the caveolae whereas only the α(1)β(1) isozyme of NKA is localized in the non-caveolae fraction of pulmonary artery smooth muscle cell membrane. It is well known that different isoforms of NKA are regulated differ...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2011.12.020

    authors： Dey K,Roy S,Ghosh B,Chakraborti S

    更新日期：2012-04-01 00:00:00

  • Calcium and spermine interaction with phospholipid bilayers: a 15N NMR study.

    abstract：:The binding of Ca2+ to membrane models composed of diplamitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) 15N-labeled in the polar head group was investigated at pH 8.5 and pH 9.4 by 15N-NMR spectroscopy. Both phospholipids exhibit a decrease in the chemical shift anisotropy, indicating c...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/0300-9084(89)90143-0

    authors： Akoka S,Tellier C

    更新日期：1989-01-01 00:00:00

  • Purification and characterization of human intestinal neutral ceramidase.

    abstract：:Sphingolipids are degraded by sphingomyelinase and ceramidase in the gut to ceramide and sphingosine, which may inhibit cell proliferation and induce apoptosis, and thus have anti-tumour effects in the gut. Although previous rodent studies including experiments on knockout mice indicate a role of neutral ceramidase in...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/j.biochi.2007.03.009

    authors： Ohlsson L,Palmberg C,Duan RD,Olsson M,Bergman T,Nilsson A

    更新日期：2007-08-01 00:00:00

  • Small RNAs derived from longer non-coding RNAs.

    abstract：:Posttranscriptional gene regulation by small RNAs and its crucial impact on development, apoptosis, stem cell self-renewal and differentiation gained tremendous scientific attention since the discovery of RNA interference (RNAi) and microRNAs (miRNAs). However, in the last few years, many more examples for regulatory ...

    journal_title：Biochimie

    pub_type： 杂志文章,评审

    doi：10.1016/j.biochi.2011.07.032

    authors： Röther S,Meister G

    更新日期：2011-11-01 00:00:00

  • Redox regulation of cytochrome P450cam mixed function oxidation by putidaredoxin and camphor ligation.

    abstract：:A methylene group of camphor is hydroxylated by a P450 monoxygenase system containing in addition to the cytochrome and flavoprotein dehydrogenase a two-iron, two-sulfur redox protein termed putidaredoxin. The regulatory control of electron transport equilibrium occurs via ligation of substrate and redoxin to the cyto...

    journal_title：Biochimie

    pub_type： 杂志文章

    doi：10.1016/s0300-9084(76)80364-1

    authors： Gunsalus IC,Sligar SG

    更新日期：1976-01-01 00:00:00