Redox regulation of cytochrome P450cam mixed function oxidation by putidaredoxin and camphor ligation.

Abstract:

:A methylene group of camphor is hydroxylated by a P450 monoxygenase system containing in addition to the cytochrome and flavoprotein dehydrogenase a two-iron, two-sulfur redox protein termed putidaredoxin. The regulatory control of electron transport equilibrium occurs via ligation of substrate and redoxin to the cytochrome. The component interactions and electron flow are represented clearly and concisely by a free energy state diagram of the coupled binding and redox transfer reactions.

journal_name

Biochimie

journal_title

Biochimie

authors

Gunsalus IC,Sligar SG

doi

10.1016/s0300-9084(76)80364-1

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

143-7

issue

1-2

eissn

0300-9084

issn

1638-6183

pii

S0300-9084(76)80364-1

journal_volume

58

pub_type

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