Abstract：
:Innate immune system is the first line of host defense against invading microorganisms. It relies on a limited number of germline-encoded pattern recognition receptors that recognize conserved molecular structures of microbes, referred to as pathogen-/microbe-associated molecular patterns (PAMPs/MAMPs). Bacterial cell wall macroamphiphiles, namely Gram-negative bacteria lipopolysaccharide (LPS), Gram-positive bacteria lipoteichoic acid (LTA), lipoproteins and mycobacterial lipoglycans, are important molecules for the physiology of bacteria and evidently meet PAMP/MAMP criteria. They are well suited to innate immune recognition and constitute non-self signatures detected by the innate immune system to signal the presence of an infective agent. They are notably recognized via their lipid anchor by Toll-like receptors (TLRs) 4 or 2. Here, we review our current knowledge of the molecular bases of macroamphiphile recognition by TLRs, with a special emphasis on mycobacterial lipoglycan detection by TLR2.
journal_name
Biochimiejournal_title
Biochimieauthors
Ray A,Cot M,Puzo G,Gilleron M,Nigou Jdoi
10.1016/j.biochi.2012.06.007subject
Has Abstractpub_date
2013-01-01 00:00:00pages
33-42issue
1eissn
0300-9084issn
1638-6183pii
S0300-9084(12)00241-6journal_volume
95pub_type
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