Abstract：
:Analysis of the nucleotide sequence of 1,400 transfer RNAs has revealed the imprint of a prototypic genetic code in position 3-4-5 of the acceptor stem. It appears only in the transfer RNAs for the primordial amino acids ie those found by chemical condensation of a nitrogen-methane-water-ammonia mixture. The model for primitive protein synthesis as mentioned by Crick assumes a direct interaction between the amino acid and a prototypic adaptor oligonucleotide. This has hitherto appeared irreconcilable with the large spatial separation between the aminoacylation site and the anticodon in present day transfer RNAs. The observations reported here show how this paradox can be resolved by a process of duplication and cleavage of a prototypic adaptor.
journal_name
Biochimiejournal_title
Biochimieauthors
Möller W,Janssen GMdoi
10.1016/0300-9084(90)90033-dsubject
Has Abstractpub_date
1990-05-01 00:00:00pages
361-8issue
5eissn
0300-9084issn
1638-6183pii
0300-9084(90)90033-Djournal_volume
72pub_type
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