Abstract：
:Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems to be closely related to their interactions with the lipid components of the plasma membrane of target cells. Despite many works devoted to the chemical synthesis and characterization of sugar-based bolaamphiphiles, their interactions with plasma membrane have not been completely elucidated. In this work, two sugar-based bolaamphiphiles differing only at the level of their sugar residues were chemically synthetized. Their interactions with membranes have been investigated using model membranes containing or not sterol and with in silico approaches. Our findings indicate that the nature of sugar residues has no significant influence for their membrane interacting properties, while the presence of sterol attenuates the interactions of both bolaamphiphiles with the membrane systems. The understanding of this distinct behavior of bolaamphiphiles towards sterol-containing membrane systems could be useful for their applications as drug delivery systems.
journal_name
Biochimiejournal_title
Biochimieauthors
Nasir MN,Crowet JM,Lins L,Obounou Akong F,Haudrechy A,Bouquillon S,Deleu Mdoi
10.1016/j.biochi.2016.04.001subject
Has Abstractpub_date
2016-11-01 00:00:00pages
23-32eissn
0300-9084issn
1638-6183pii
S0300-9084(16)30043-8journal_volume
130pub_type
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