Abstract：
:A large part of higher eukaryotic genomes is transcribed into RNAs lacking any significant open reading frame. This "non-coding part" has been shown to actively contribute to regulating gene expression, but the mechanisms are largely unknown. Particularly instructive examples are provided by the dosage compensation systems, which assure that the single X chromosome in male cells and the two X chromosomes in female cells give rise to similar amounts of gene product. Although this is achieved by very different strategies in mammals and fruit flies, long, non-coding RNAs (lncRNAs) are involved in both cases. Here we summarize recent progress towards unraveling the mechanisms, by which the Xist and roX RNAs mediate the selective association of regulators with individual target chromosomes, to initiate dosage compensation in mammals and fruit flies, respectively.
journal_name
Biochimiejournal_title
Biochimieauthors
Maenner S,Müller M,Becker PBdoi
10.1016/j.biochi.2011.12.026subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1490-8issue
7eissn
0300-9084issn
1638-6183pii
S0300-9084(12)00002-8journal_volume
94pub_type
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