Abstract：
:Nucleic acid Aptamers are ligands that are selected by a process of molecular evolution to bind with high affinities and specificities to a specific target. Recently, an increasing number of aptamers have been selected against biomarkers expressed at the surface of human cells or infectious pathogens. This class of targets, mostly proteins, is associated with several pathologies including cancer, inflammation and infection diseases. Several of these cell surface specific aptamers were tested in vivo as drugs or as targeting agents for nanocarriers, siRNA or contrast agents. Strikingly, they were used to develop a wide variety of new treatments or new approaches for molecular imaging and they were also able to improve current therapies such as chemotherapy, radiotherapy or immunotherapy. This review presents these different applications and the different studies conducted in vivo with this class of aptamers, predominantly in pre-clinical models.
journal_name
Biochimiejournal_title
Biochimieauthors
Cibiel A,Pestourie C,Ducongé Fdoi
10.1016/j.biochi.2012.02.025subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1595-606issue
7eissn
0300-9084issn
1638-6183pii
S0300-9084(12)00084-3journal_volume
94pub_type
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