Abstract:
:Treatment of wild type Escherichia coli with cis -Pt(NH3)2Cl2 increased the survival and frequency of clear plaques formation of lambda phage damaged by UV radiation. The reactivation process was present in an uvrA mutant and abolished in a lexA host. Trans-Pt(NH3)2Cl2 and [Pt(dien) Cl]Cl (dien = 2HN-CH2-CH2NH-CH2-CH2-NH2) which, inhibited DNA synthesis less than the cis isomer or not at all, respectively, induced only a slight increase in survival of UV irradiated phage while mutagenesis was not affected. A relation exists between the reactivation of UV damaged phage in bacteria treated with these three compounds and their recently reported abilities to inhibit DNA synthesis and induce recA protein.
journal_name
Biochimiejournal_title
Biochimieauthors
Alazard RJ,Germanier Mdoi
10.1016/s0300-9084(82)80099-0subject
Has Abstractpub_date
1982-08-01 00:00:00pages
619-22issue
8-9eissn
0300-9084issn
1638-6183pii
S0300-9084(82)80099-0journal_volume
64pub_type
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