Abstract：
:Ton-dependent colicins and microcins are actively taken up into sensitive cells at the expense of energy which is provided by the proton motive force of the cytoplasmic membrane. The Ton system consisting of the proteins TonB, ExbB and ExbD is required for colicin and microcin import. Colicins as well as the outer membrane transport proteins contain proximal to the N-terminus a short sequence, called TonB box, which interacts with TonB and in which point mutants impair uptake. No TonB box is found in microcins. Colicins are composed of functional modules which during evolution have been interchanged resulting in new colicins. The modules define sites of interaction with the outer membrane transport genes, TonB, the immunity proteins, and the activity regions. Six TonB-dependent microcins with different primary structures are processed and exported by highly homologous proteins. Three of these microcins are modified in an unknown way and they have in common specificity for catecholate siderophore receptors.
journal_name
Biochimiejournal_title
Biochimieauthors
Braun V,Patzer SI,Hantke Kdoi
10.1016/s0300-9084(02)01427-xkeywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
365-80issue
5-6eissn
0300-9084issn
1638-6183pii
S030090840201427Xjournal_volume
84pub_type
杂志文章,评审相关文献
BIOCHIMIE文献大全abstract：:The microbial resistance to antibiotics is a genuine global threat. Consequently, a search of new inhibitors remains of acute importance due to the increasing spread of multidrug resistance. Here we present a new type of non-β-lactam β-lactamase inhibitor PA-34 based on natural phenoxyaniline, identified using compute...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2016.10.011
更新日期：2017-01-01 00:00:00
abstract：:Cell-to-cell movement of Poa semilatent virus (genus Hordeivirus) in infected plants is mediated by three viral 'triple gene block' (TGB) proteins. One of those termed TGBp3 is an integral membrane protein essential for intracellular transport of other TGB proteins and viral genomic RNA to plasmodesmata. TGBp3 targeti...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2011.01.002
更新日期：2011-04-01 00:00:00
abstract：:We screened a cDNA library of the primitive eukaryote Dictyostelium discoideum constructed in the expression vector lambda gt11 with a specific antiserum directed against S-adenosyl-L-homocysteine hydrolase (AdoHcy hydrolase) and isolated cDNA clones coding for fusion proteins with beta-galactosidase. The identity of ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(88)90115-0
更新日期：1988-06-01 00:00:00
abstract：:The termination of protein synthesis in bacteria requires codon-specific polypeptide release factors RF-1 (UAG/UAA specific) and RF-2 (UGA/UAA specific). We have proposed that release factors mimic tRNA and recognize the stop codon for polypeptide release (Nakamura et al (1996) Cell 87, 147-150). In contrast to the te...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(97)86715-6
更新日期：1996-01-01 00:00:00
abstract：:IL-28 and IL-29 were recently described as members of a new cytokine family that shares with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a common set of genes. Accordingly, they have been named IFN lambda. IFNs lambda exhibit several common features with type I IFNs: antiviral ac...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2007.01.008
更新日期：2007-06-01 00:00:00
abstract：:Pterocarpans, a family of isoflavonoids found in the diverse Fabaceae, display potent cytotoxic activity over a panel of tumor cell lines, and among those tested, 2,3,9- trimethoxypterocarpan displays the most potent activity. This study evaluates the effects of 2,3,9-trimethoxypterocarpan and its related derivatives ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.06.005
更新日期：2014-09-01 00:00:00
abstract：:1) Isonitrile derivatives of synthetic polyamides, polyesters and polyalcohols, of polysaccharides such as cellulose, cross-linked dextran and agarose, linear dextran and of cross-linked and linear polyacrylamide were prepared. 2) Proteins and low-molecular-weight ligands were bound covalently to these materials by fo...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(80)80172-6
更新日期：1980-01-01 00:00:00
abstract：:The use of electrospun scaffolds for neural tissue engineering applications allows a closer mimicry of the native tissue extracellular matrix (ECM), important for the transplantation of cells in vivo. Moreover, the role of the electrospun fiber mat topography on neural stem cell (NSC) differentiation remains to be com...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2021.01.001
更新日期：2021-01-07 00:00:00
abstract：:We have recently reported that α(2)β(1) and α(1)β(1) isozymes of Na(+)/K(+)-ATPase (NKA) are localized in the caveolae whereas only the α(1)β(1) isozyme of NKA is localized in the non-caveolae fraction of pulmonary artery smooth muscle cell membrane. It is well known that different isoforms of NKA are regulated differ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2011.12.020
更新日期：2012-04-01 00:00:00
abstract：:Protein-induced DNA bridging and looping is a common mechanism for various and essential processes in bacterial chromosomes. This mechanism is preserved despite the very different bacterial conditions and their expected influence on the thermodynamic and kinetic characteristics of the bridge formation and stability. O...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2017.08.002
更新日期：2017-11-01 00:00:00
abstract：:Tryptocidine C (TpcC, cyclo[D-Phe1-Pro2-Trp3-D-Trp4-Asn5-Gln6-Trp7-Val8-Orn9-Leu10]) is a broad-spectrum antimicrobial peptide in the tyrothricin complex produced by a soil bacterium, Brevibacillus parabrevis. Electrospray mass spectrometric studies reveal the oligomerisation of TpcC into dimers and higher oligomers, ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2020.12.006
更新日期：2020-12-18 00:00:00
abstract：:In recent years the chaperone HSC-70 has become a target for drug design with a strong focus in anticancer therapies. In our study of possible inhibitors of HSC-70 enzymatic activity we screened compounds by NMR as well as X-ray crystallography. As part of our screening efforts we crystallized the human HSC-70 ATP bin...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.11.012
更新日期：2015-01-01 00:00:00
abstract：:The kinetics of the native glycogen phosphorylase b from rabbit skeletal muscle and of the enzyme specifically deiminated by peptidylarginine deiminase have been studied. One arginine residue per phosphorylase b monomer is transformed into citrulline after 3 h of incubation with peptidylarginine deiminase. The maximal...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(96)82188-2
更新日期：1996-01-01 00:00:00
abstract：:As the medaka is a popular fish model in genetics, developmental biology and toxicology, the development of an efficient transgenic medaka technique is important for a variety of biological experiments. Here we demonstrated that the maize transposon system, Ac/Ds, greatly improved the transgenesis of microinjected DNA...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2011.07.006
更新日期：2011-10-01 00:00:00
abstract：:Hemorrhage is the most potent manifestation of envenomation by Vipera ammodytes ammodytes (V. a. ammodytes) venom in man. A detailed description of the venom components contributing to this effect is thus medically very important. We have characterized a novel component, termed here VaH3, as a potently hemorrhagic sna...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2013.01.003
更新日期：2013-06-01 00:00:00
abstract：:Thorium-232 ((232)Th), a natural radionuclide from the actinide family, is abundantly present in monazite and other ores. It is used as one of the prime fuel materials in nuclear industry and may pose an exposure risk to nuclear workers and members of the public. Human erythrocytes, as a classical cellular membrane mo...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2010.03.008
更新日期：2010-07-01 00:00:00
abstract：:Lactic acid bacteria provide a model system for the in vivo study of mechanisms pertaining to the regulation of sugar transport and metabolism by microorganisms. Recent studies with resting and growing cells of the homofermentative Streptococci and Lactobacilli have yielded evidence for hitherto unsuspected regulatory...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(88)90205-2
更新日期：1988-03-01 00:00:00
abstract：:The effects of DNA oligonucleotides complementary to potato spindle tuber viroid (PSTVd) on viroid infection were investigated. The oligonucleotides were used to form hybrids with PSTVd in the infection mixture. A 75% reduction of viroid infection was found when an oligonucleotide complementary to nucleotides 79-110 o...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(93)90026-o
更新日期：1993-01-01 00:00:00
abstract：:Thyroid peroxidase (TPO) is the key enzyme involved in thyroid hormone synthesis. Autoantibodies to TPO (TPOAbs) are a hallmark of autoimmune thyroid disease (AITD). Here, we highlight recent progress over several years in understanding TPO biochemistry and function in various pathologies. TPO undergoes complex post-t...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2019.02.003
更新日期：2019-05-01 00:00:00
abstract：:The complete amino acid sequences of 3 proteins from the 50S subunit of Bacillus stearothermophilus ribosomes were determined by N-terminal sequence analysis and by sequencing of overlapping fragments obtained from enzymatic digestions and chemical cleavages. The proteins BstL28, BstL33 and BstL34, named according to ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(91)90126-l
更新日期：1991-07-01 00:00:00
abstract：:This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth. ...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(94)90185-6
更新日期：1994-01-01 00:00:00
abstract：:The iron absorption by duodenal enterocytes is a key step of its homeostasis. But the control of this absorption is complex and cannot be fully explicated with present knowledge. In a global transcriptome approach, we identified 60 genes over-expressed in hemin (iron) overload in Caco-2 cells, an in vitro model of duo...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2008.01.002
更新日期：2008-04-01 00:00:00
abstract：UNLABELLED:Pancreatic cancer (PC) is one of the most lethal human malignancies and a major health problem. Patients diagnosed with PC and treated with conventional approaches have an overall 5-year survival rate of less than 5%. Novel strategies are needed to treat this disease. Herein, we propose a combinatorial strat...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.07.012
更新日期：2015-09-01 00:00:00
abstract：:The term 'RNA editing' was used for the first time in 1986 to describe the process of uridylate insertion into trypanosomal mitochondrial transcripts. Since then, the term has been used more generally to describe a large variety of processes involving base insertions, deletions and conversions that generate RNAs with ...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(96)84757-2
更新日期：1996-01-01 00:00:00
abstract：:Staphylococcus aureus is one of the most dreaded pathogens worldwide and emergence of notorious antibiotic resistant strains have further exacerbated the present scenario. The glycolytic enzyme, triosephosphate isomerase (TIM) is one of the cell envelope proteins of the coccus and is involved in biofilm formation. It ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2012.07.001
更新日期：2012-12-01 00:00:00
abstract：:During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trial...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.09.009
更新日期：2015-11-01 00:00:00
abstract：:The translation factor EF-P is required for efficient prokaryotic peptide bond synthesis on 70S ribosomes from fMet-tRNAfMet. This protein has been purified from Escherichia coli cells and the gene, efp, encoding it has been cloned and sequenced. We have isolated recombinant clones which overexpress a protein that co-...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(97)87619-5
更新日期：1997-01-01 00:00:00
abstract：:In septic shock patients, alterations of plasma phospholipid fatty acid profile have never been described. The purpose of this monocentric, non-interventional, observational prospective study was to describe this fatty acid profile in the early phase of septic shock in intensive care unit. Thirty-seven adult patients ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2013.08.006
更新日期：2013-11-01 00:00:00
abstract：:NADH cytochrome b5 oxidoreductase (Ncb5or) protects β-cells against oxidative stress and lipotoxicity. The predominant phenotype of lean Ncb5or-null mouse is insulin-dependent diabetes due to β-cell death. This suggests the putative role of NCB5OR polymorphism in human diabetes. Therefore, we aimed to investigate the ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2013.03.004
更新日期：2013-07-01 00:00:00
abstract：:Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(03)00136-6
更新日期：2003-07-01 00:00:00
