Abstract：
:Disappearance of 7-ethylguanine and O6-ethylguanine lesions from nuclear DNA is observed on incubation of isolated rat liver nuclei previously treated with ethylnitrosourea. Free 7-ethylguanine but no free O6-ethylguanine is released in the medium. Incubation of methylated or ethylated DNA with chromatin proteins leads to the disappearance of O6-methylguanine or O6-ethylguanine from DNA; the methyl group or the ethyl group is transferred to proteins where it is accepted by cystein residues. Repair of O6-methylguanine and repair of O6-ethylguanine lesions in DNA consume a common reactant which is likely the acceptor protein. The repair does not seem however to be a simple bimolecular reaction between the O6-alkylguanine and the cystein of the acceptor protein.
journal_name
Biochimiejournal_title
Biochimieauthors
Renard A,Lemaitre M,Verly WGdoi
10.1016/s0300-9084(82)80132-6subject
Has Abstractpub_date
1982-08-01 00:00:00pages
803-4issue
8-9eissn
0300-9084issn
1638-6183pii
S0300-9084(82)80132-6journal_volume
64pub_type
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