Abstract：
:Neuropeptides and hormones, in contrast to constitutive secretory proteins, are sorted to and stored in secretory granules and released upon a stimulus. During the last two decades, signals and mechanisms involved in their sorting to the regulated pathway of protein secretion have been addressed in numerous studies. Taken together these studies revealed three important features of regulated secretory proteins: aggregation, sorting signal motifs and membrane binding. Here we try to dissect the sorting process with regard to these features and discuss their relevance in the context of current sorting models. We especially address the question where in the secretory pathway sorting takes place and discuss a possible role of sorting receptors.
journal_name
Biochimiejournal_title
Biochimieauthors
Glombik MM,Gerdes HHdoi
10.1016/s0300-9084(00)00195-4keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
315-26issue
4eissn
0300-9084issn
1638-6183pii
S0300-9084(00)00195-4journal_volume
82pub_type
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