Abstract：
:Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus, in the nucleoplasm, cytoplasm as well as on the cell membrane. It acts in all cell compartments to control cellular homeostasis and therefore each cellular pool of NCL can play a different role in cancer development. NCL overexpression and its increased localization at the cell membrane is a common feature of several tumor cells. In cancer cells, NCL overexpression influences cell survival, proliferation and invasion through its action on different cellular pathways. In this review, we describe how the multiple functions of NCL that are associated to its multiple cellular localization can participate to the development of cancer.
journal_name
Biochimiejournal_title
Biochimieauthors
Berger CM,Gaume X,Bouvet Pdoi
10.1016/j.biochi.2015.03.023subject
Has Abstractpub_date
2015-06-01 00:00:00pages
78-85eissn
0300-9084issn
1638-6183pii
S0300-9084(15)00102-9journal_volume
113pub_type
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