Abstract:
:The present study reports the first complete genome sequence analysis of West Nile virus (WNV) strains isolated from brain samples from raptors. The results prove the circulation of closely related WNV lineage II strains in central Europe and genetic analysis revealed seven amino acid substitutions in structural (PrM3, E159 and E231) and in non-structural (NS1109, NS5259, NS5310 and NS5600) proteins. Observed amino acid substitutions Phe3 and Ser231 were common only within the lineage VII Koutango strain isolated from Rhipicephalus guilhoni tick in Senegal. Further research could reveal whether these substitutions influence the biological properties of WNV, including virulence and neuroinvasiveness.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Drzewnioková P,Barzon L,Franchin E,Lavezzo E,Bakonyi T,Pistl J,Csank Tdoi
10.1007/s00705-018-4056-7subject
Has Abstractpub_date
2019-01-01 00:00:00pages
273-277issue
1eissn
0304-8608issn
1432-8798pii
10.1007/s00705-018-4056-7journal_volume
164pub_type
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