The complete genome sequence analysis of West Nile virus strains isolated in Slovakia (central Europe).

Abstract:

:The present study reports the first complete genome sequence analysis of West Nile virus (WNV) strains isolated from brain samples from raptors. The results prove the circulation of closely related WNV lineage II strains in central Europe and genetic analysis revealed seven amino acid substitutions in structural (PrM3, E159 and E231) and in non-structural (NS1109, NS5259, NS5310 and NS5600) proteins. Observed amino acid substitutions Phe3 and Ser231 were common only within the lineage VII Koutango strain isolated from Rhipicephalus guilhoni tick in Senegal. Further research could reveal whether these substitutions influence the biological properties of WNV, including virulence and neuroinvasiveness.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Drzewnioková P,Barzon L,Franchin E,Lavezzo E,Bakonyi T,Pistl J,Csank T

doi

10.1007/s00705-018-4056-7

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

273-277

issue

1

eissn

0304-8608

issn

1432-8798

pii

10.1007/s00705-018-4056-7

journal_volume

164

pub_type

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