Comparison of the humoral and cellular immune response after immunization with live, UV inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunizations.

Abstract:

:Antibody and cell-mediated immune responses were measured in rabbits immunized with live, UV inactivated herpes simplex virus or with a subunit vaccine containing envelope proteins. All the types of immunization procedures induced the production of antibody as well as a specific cellular immunity. Furthermore, the subunit vaccine was as effective as the immunization with live or UV inactivated virus to prevent death upon challenge with live HSV. Live HSV induced a transient unresponsiveness of both B and T cells to in vitro stimulation with various mitogens.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Cappel R

doi

10.1007/BF01317862

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

29-35

issue

1-2

eissn

0304-8608

issn

1432-8798

journal_volume

52

pub_type

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