Abstract：
:Infections with influenza and respiratory syncytial virus (RSV) rank high among the most common human respiratory diseases worldwide. Previously, we developed a replication-incompetent influenza virus by replacing the coding sequence of the PB2 gene, which encodes one of the viral RNA polymerase subunits, with that of a reporter gene. Here, we generated a PB2-knockout recombinant influenza virus expressing the F protein of RSV (PB2-RSVF virus) and tested its potential as a bivalent vaccine. In mice intranasally immunized with the PB2-RSVF virus, we detected high levels of antibodies against influenza virus, but not RSV. PB2-RSVF virus-immunized mice were protected from a lethal challenge with influenza virus but experienced severe body weight loss when challenged with RSV, indicating that PB2-RSVF vaccination enhanced RSV-associated disease. These results highlight one of the difficulties of developing an effective bivalent vaccine against influenza virus and RSV infections.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Fonseca W,Ozawa M,Hatta M,Orozco E,Martínez MB,Kawaoka Ydoi
10.1007/s00705-013-1932-zsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
1067-77issue
5eissn
0304-8608issn
1432-8798journal_volume
159pub_type
杂志文章abstract：:In cultured chicken embryo fibroblasts treated with copper-(copper cation 10-minus 3.5-10-minus 5 M), nickel and cobalt salts an enhancement of the plating efficiency of Semliki Forest virus could be observed. This augmented plaque formation was most probably due to a higher adsorption rate of virions to the cell surf...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315593
更新日期：1975-01-01 00:00:00
abstract：:The value of serologic tests for diagnosis of swine influenza virus (SIV) infection has been diminished by the emergence of new subtypes and by antigenic drift within subtype. The intensive use of vaccination also has complicated interpretation of serology results. Serologic assays are needed that can detect infection...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-005-0615-9
更新日期：2006-01-01 00:00:00
abstract：:Amino acid positions recognized by monoclonal antibodies (MAbs) in the influenza A virus nucleoprotein (NP) have been reported. As these residues were scattered in the three-dimensional (3D) structure of NP, no patterns of the architecture of antibody-binding sites could be inferred. Here, we used site-specific mutage...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-013-1952-8
更新日期：2014-06-01 00:00:00
abstract：:Human adenoviruses (Ad) 5 and 7 multiplied poorly in guinea-pig cell cultures as compared to HeLa cells. Ad 7 had a modified polypeptide composition with a major 43K component. This change persisted for up to 4 passages in HeLa cells. Ad 5 was not changed by passage in guinea-pig cells. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01320631
更新日期：1980-01-01 00:00:00
abstract：:A plaque assay was developed for feline parvovirus (FPV; feline panleucopaenia virus) in a feline embryo (FEmb) cell line. Higher numbers and larger diameter plaques were obtained with a) seeding rates of 0.7 X 10(5) and 1.5 X 10(5) cells cf. 3 X 10(5) and 6 X 10(5) cells/well of 35 mm diameter, b) synchronised cells ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01378978
更新日期：1985-01-01 00:00:00
abstract：:Since late 2018, foot-and-mouth disease (FMD) has reemerged and rapidly swept through pig farms in North and Central Vietnam, despite widespread use of commercial FMD vaccines. To investigate the FMD virus (FMDV) strains responsible for the current epidemics, 40 FMDV samples were collected from 17 provinces during Nov...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04763-8
更新日期：2020-11-01 00:00:00
abstract：:Dengue and chikungunya viruses co-circulate and cause infections that start with similar symptoms but progress to radically different outcomes. Therefore, an early diagnostic test that can differentiate between the two is needed. A single-step multiplex real-time RT-PCR assay was developed that can simultaneously dete...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2217-x
更新日期：2015-01-01 00:00:00
abstract：:Twenty-two strains of influenza A virus isolated from caged birds which had been imported into Japan from India and Thailand and had died druing transportation to Tokyo. Serological tests divided these strains into two groups. Viruses in the first group contained Hav7 hemagglutinin and were related antigenically to A/...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01315090
更新日期：1978-01-01 00:00:00
abstract：:In 2010, yam beans in a field trial in Peru showed viral disease symptoms. Graft-transmission and positive ELISA results using potyvirus-specific antibodies suggested that the symptoms could be the result of a potyviral infection. Small interfering RNA (siRNA) were extracted from one of the samples and sent for high-t...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-011-1214-6
更新日期：2012-04-01 00:00:00
abstract：:Two cases of coinfection with bovine papular stomatitis virus (BPSV) and pseudocowpox virus (PCPV) in dairy calves in Tochigi Prefecture, Japan, are reported. Sequences of BPSV and PCPV were simultaneously detected in the same polymerase chain reaction (PCR) amplicons, which were obtained from the DNA of two dairy cal...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04792-3
更新日期：2020-11-01 00:00:00
abstract：:JC virus (JCV) strains worldwide can be classified into various genotypes based on DNA sequence variations. To define the domains of the four major JCV genotypes in Asia, we collected urine samples at six unstudied sites: three in southeastern Asia, two in the central highlands and one in central Asia. DNA was extract...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s705-002-8299-4
更新日期：2002-01-01 00:00:00
abstract：:Porcine respiratory coronavirus (PRCV), a spike (S) gene deletion mutant of Transmissible gastroenteritis virus (TGEV), causes mild or subclinical respiratory infections in pigs. The shedding of PRCV/TGEV was studied at different days post-arrival in fecal and nasal swabs from PRCV/TGEV seronegative sentinel pigs intr...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0245-z
更新日期：2004-05-01 00:00:00
abstract：:A large sheep flock screened over a two-year period showed active spreading of Schmallenberg virus (SBV) during the summers of 2011 and 2012. Transplacental infections were observed during the two associated lambing periods (the winters of 2012 and 2013). Analysis of small (S) segment sequences of 38 SBV-positive samp...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2787-x
更新日期：2016-05-01 00:00:00
abstract：:We investigated the potential of Nicotiana benthamiana to express the E7 protein of human papillomavirus 8 (HPV-8), a paradigm genotype among cutaneous HPVs. The protein, modified in its putative pRb-binding domain (E7(QGD)), was transiently expressed in leaves following infiltration with agrobacteria carrying either ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-010-0893-8
更新日期：2011-04-01 00:00:00
abstract：:A small unconventional, viroid-like aetiological agent might initiate Crohn's disease (CD). Electrophoresis of radiolabelled low molecular weight nucleic acids from mesenteric lymph nodes and leucocytes did not distinguish CD-specific sequences compatible with a viroid-like agent. ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310895
更新日期：1986-01-01 00:00:00
abstract：:The leafhopper Euscelidius variegatus is a natural vector of chrysanthemum yellows phytoplasma (CY) and an efficient vector of flavescence dorée phytoplasma (FD) under laboratory conditions. During a transcriptome sequencing (RNA-seq) project aimed at investigating the interactions between the insect and the two phyto...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-3158-3
更新日期：2017-03-01 00:00:00
abstract：:In our attempt to isolate mutant cell lines resistant to Newcastle disease virus (NDV) we developed an improved procedure for enrichment of NDV-resistant cells from mouse FM3A cells and isolated a novel NDV-resistant mutant cell line, Had-2, with characteristics different from Had-1, a previously reported NDV-receptor...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01310796
更新日期：1994-01-01 00:00:00
abstract：:Cotton, the major cash crop in Pakistan, suffers 30% losses to cotton leaf curl disease, caused by the geminivirus, cotton leaf curl virus DNA A, plus a satellite component, DNA beta responsible for symptom development with plants failing to produce cotton bolls. We constructed transgenic tobacco expressing sense and ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0179-5
更新日期：2003-12-01 00:00:00
abstract：:Hippeastrum chlorotic ringspot virus (HCRV) is a novel tospovirus that was identified in Yunnan Province, China, in 2013. We have sequenced the HCRV L gene, which is 8909 nt long and encodes the RNA-dependent RNA polymerase (2873 amino acids, 330.8 kDa). The HCRV L protein shared highest similarity (89.4 %) with that ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2100-9
更新日期：2014-10-01 00:00:00
abstract：:Tetracyclines have been used to treat many bacterial infections. The use of these antibiotics for the treatment of viral diseases dates to the 1960s to 1970s. Over the decades, the effect of tetracyclines on the pathogenesis of viral infections has been demonstrated both clinically and experimentally. Tetracyclines ca...
journal_title：Archives of virology
pub_type： 杂志文章,评审
doi：10.1007/s00705-020-04860-8
更新日期：2021-01-01 00:00:00
abstract：:Fowl adenoviruses (FAdVs) are widely distributed in chickens in Poland and throughout the world. FAdV infections have been reported in the United States, Australia, Europe, and the Mediterranean basin. Detection of FAdVs strains is very important from the epidemiological point of view and for monitoring disease outbre...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-015-2635-4
更新日期：2016-01-01 00:00:00
abstract：:Antisera from dengue patients and dengue virus infected rabbits recognized octapeptides corresponding to linear amino acid sequences in the envelope protein of dengue 2 (Jamaica 1409). Although no peptide was recognized by sera from all dengue infected hosts, two peptides (216LPLPWLPG223 and 448FSGVSWTM455) were recog...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/BF01311358
更新日期：1989-01-01 00:00:00
abstract：:Big liver and spleen disease, caused by avian hepatitis E virus, has been reported in Poland, but the prevalence of the virus has not yet been investigated. In this study, 1034 serum samples from 57 breeder broiler and laying hen flocks were screened for the presence of anti-aHEV antibodies. In a random serology study...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4089-y
更新日期：2019-02-01 00:00:00
abstract：:The genome of yam virus X (YVX), a new member of the genus Potexvirus from yam (Dioscorea trifida), was completely sequenced. Structural and phylogenetic analysis showed that the closest relative of YVX is nerine virus X. A prevalence study found YVX only in plants maintained in Guadeloupe and showed that it also infe...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-014-2211-3
更新日期：2014-12-01 00:00:00
abstract：:Bovine leukemia virus (BLV), the etiologic agent of enzootic bovine leucosis, has caused pandemic outbreaks worldwide. Because transcription of the BLV is quickly blocked after infection, detecting integrated provirus at host genome is an important method of identifying whether an animal is infected. The aim of the pr...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-2806-y
更新日期：2016-06-01 00:00:00
abstract：:The complete genome sequences of two grapevine virus L (GVL) isolates collected from the wine grape cultivar Blanc du Bois (Vitis spp.: 'Florida D 6-148'×'Cardinal') in Texas were determined. The two genome sequences (excluding the polyA tail) were each 7594 nucleotide long and 99.7% identical to each other, but they ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-020-04682-8
更新日期：2020-08-01 00:00:00
abstract：:A potyvirus isolated from Pinellia ternata in China was characterised and shown to be related to Soybean mosaic virus (SMV). The virus was pathogenic on P. ternata and some soybean cultivars, whereas the local soybean SMV isolate HH5 did not infect P. ternata. Western blot experiments demonstrated a serological relati...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-003-0184-8
更新日期：2004-02-01 00:00:00
abstract：:Macrophage (mac)-tropic human immnunodeficiency virus type 1 (HIV-1) and simian immnunodeficiency virus (SIV) in brain are associated with neurological disease. Mac-tropic HIV-1 evolves enhanced CD4 interactions that enable macrophage infection via CD4, which is in low abundance. In contrast, mac-tropic SIV is associa...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-018-4094-1
更新日期：2019-02-01 00:00:00
abstract：:Vector transmission is an important part of the viral infection cycle, yet for many viruses little is known about this process, or how viral sequence variation affects transmission efficacy. Here we examined the effect of substituting genes from the highly transmissible FS577 isolate of citrus tristeza virus (CTV) in ...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-016-3070-x
更新日期：2016-12-01 00:00:00
abstract：:The objectives of this study were to determine the antigenic relationship among ruminant adenoviruses and determine their phylogenetic relationship based on the deduced hexon gene amino acid sequence. Results of reciprocal cross-neutralization tests demonstrated antigenic relationships in either one or both directions...
journal_title：Archives of virology
pub_type： 杂志文章
doi：10.1007/s00705-008-0063-4
更新日期：2008-01-01 00:00:00
