Abstract:
:Vector transmission is an important part of the viral infection cycle, yet for many viruses little is known about this process, or how viral sequence variation affects transmission efficacy. Here we examined the effect of substituting genes from the highly transmissible FS577 isolate of citrus tristeza virus (CTV) in to the poorly transmissible T36-based infectious clone. We found that introducing p65 or p61 sequences from FS577 significantly increased transmission efficacy. Interestingly, replacement of both genes produced a greater increase than either gene alone, suggesting that CTV transmission requires the concerted action of co-evolved p65 and p61 proteins.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Harper SJ,Killiny N,Tatineni S,Gowda S,Cowell SJ,Shilts T,Dawson WOdoi
10.1007/s00705-016-3070-xsubject
Has Abstractpub_date
2016-12-01 00:00:00pages
3555-3559issue
12eissn
0304-8608issn
1432-8798pii
10.1007/s00705-016-3070-xjournal_volume
161pub_type
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